Akkus A, Yang S, Roperto R, Mustafa H, Teich S, Akkus O. A portable fiber-optic raman spectrometer concept for evaluation of mineral content within enamel tissue. J Clin Exp Dent. 2017;9(2):e238-41.







1. Leichter I, Margulies JY, Weinreb A, Mizrahi J, Robin GC, Conforty B, Makin M, Bloch B. The relationship between bone density, mineral content, and mechanical strength in the femoral neck. Clin Orthop Relat Res. 1982;163:272-81.

PMid: 7067262


2. Hodgskinson R, Currey JD, Evans GP. Hardness, an indicator of the mechanical competence of cancellous bone. J Orthop Res. 1989;7:754-8.



3. Kinney JH, Balooch M, Marshall SJ, Marshall GW Jr, Weihs TP. Hardness and Young's modulus of human peritubular and intertubular dentine. Arch Oral Biol. 1996;41:9-13.

PMid: 8833584


4. Kodaka T, Debari K, Yamada M, Kuroiwa M. Correlation between microhardness and mineral content in sound human enamel (short communication). Caries Res. 1992;26:139-41.

PMid: 1325874


5. Baldassarri M, Margolis HC, Beniash E. Compositional determinants of mechanical properties of enamel. J Dent Res. 2008;87:645-9.

PMid: 18573984 PMCid: PMC2658820


6. William V, Burrow MF, Palamara JE, Messer LB. Microshear bond strength of resin composite to teeth affected by molar hypomineralization using 2 adhesive systems. Pediatr Dent. 2006;28:233-41. PMid: 16805355


7. Gerdin PO, Astrand K. Enamel roentgen density. I. Enamel roentgen density in deciduous teeth from six-year-old children with and without caries prevalence. Sven Tandlak Tidskr. 1969;62:805-14.

PMid: 5267063


8. Shellis RP. Relationship between human enamel structure and the formation of caries-like lesions in vitro. Arch Oral Biol. 1984;29:975-81.



9. Targino AG, Rosenblatt A, Oliveira AF, Chaves AM, Santos VE. The relationship of enamel defects and caries: a cohort study. Oral Dis. 2011;17:420-6.

doi: 10.1111/j.1601-0825.2010.01770.x.

PMid: 21114593


10. He B, Huang S, Zhang C, Jing J, Hao Y, Xiao L, et al. Mineral densities and elemental content in different layers of healthy human enamel with varying teeth age. Arch Oral Biol. 2011;56:997-1004.


PMid: 21411061


11. Wong FS, Elliott JC, Davis GR, Anderson P. X-ray microtomographic study of mineral distribution in enamel of mandibular rat incisors. J Anat. 2000;196:405-13.

PMid: 10853962 PMCid: PMC1468076


12. Wong FS, Anderson P, Fan H, Davis GR. X-ray microtomographic study of mineral concentration distribution in deciduous enamel. Arch Oral Biol. 2004;49:937-44.

PMid: 15353251


13. Farah RA, Swain MV, Drummond BK, Cook R, Atieh M. Mineral density of hypomineralised enamel. J Dent. 2010;38:50-8.


PMid: 19737596


14. Jeng YR, Lin TT, Wong TY, Chang HJ, Shieh DB. Nano-mechanical properties of fluoride-treated enamel surfaces. J Dent Res. 2008;87:381-5.



15. Efeoglu N, Wood D, Efeoglu C. Microcomputerised tomography evaluation of 10% carbamide peroxide applied to enamel. J Dent. 2005;33:561-7.



16. Efeoglu N, Wood DJ, Efeoglu C. Thirty-five percent carbamide peroxide application causes in vitro demineralization of enamel. Dent Mater. 2007;23:900-4.

PMid: 16997368


17. He B, Huang S, Jing J, Hao Y. Measurement of hydroxyapatite density and Knoop hardness in sound human enamel and a correlational analysis between them. Arch Oral Biol. 2010;55:134-41.

doi: 10.1016/j.archoralbio.2009.12.005.

PMid: 20064635


18. Zheng Q, Xu H, Song F, Zhang L, Zhou X, Shao Y, et al. Spatial distribution of the human enamel fracture toughness with aging. J Mech Behav Biomed Mater. 2013;26:148-54.

doi: 10.1016/j.jmbbm.2013.04.025.

PMid: 23768625


19. Atar M, Davis GR, Verry P, Wong FS. Enamel mineral concentration in diabetic rodents. Eur Arch Paediatr Dent. 2007;8:195-200.

PMid: 18076850


20. Koehne T, Marshall RP, Jeschke A, Kahl-Nieke B, Schinke T, Amling M. Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization. Bone. 2013;53:25-33.


PMid: 23174213


21. Ko AC, Hewko M, Sowa MG, Dong CC, Cleghorn B, Choo-Smith LP. Early dental caries detection using a fibre-optic coupled polarization-resolved Raman spectroscopic system. Opt Express. 2008;16:6274-84.


PMCid: PMC2435308


22. Okagbare PI, Esmonde-White FW, Goldstein SA, Morris MD. Development of non-invasive Raman spectroscopy for in vivo evaluation of bone graft osseointegration in a rat model. Analyst. 2010;135:3142-6.


PMid: 20924520

PMCid: PMC2987463


23.  Currey JD. Effects of differences in mineralization on the mechanical properties of bone. Philos Trans R Soc Lond B Biol Sci. 1984;304:509-18.

PMid: 6142490


24. Yerramshetty JS, Akkus O. The associations between mineral crystallinity and the mechanical properties of human cortical bone. Bone. 2008;42:476-82.

doi: 10.1016/j.bone.2007.12.001.

PMid: 18187375


25. Akkus O, Polyakova-Akkus A, Adar F, Schaffler MB. Aging of microstructural compartments in human compact bone. J Bone Miner Res. 2003;18:1012-9.

PMid: 12817753