Martínez-García MA, Migueláñez-Medrán BC, Goicoechea C. Animal models in the study and treatment of orofacial pain. J Clin Exp Dent. 2019;11(5):e382-90.

 

doi:10.4317/jced.55429

http://dx.doi.org/10.4317/jced.55429

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References

1. Torres RCS, Marques KS, Leal KNR, Rocha-Filho PAS. Main reasons for medical consultations in family healthcare units in the city of Recife, Brazil: a cross-sectional study. Sao Paulo Med J. 2015;133:367–70.
https://doi.org/10.1590/1516-3180.2014.9490902
PMid:26517148

 

2. Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. Eur J Pain 2006;10:287-333.
https://doi.org/10.1016/j.ejpain.2005.06.009
PMid:16095934

 

3. Wirz S, Ellerkmann RK, Buechaler M, Putensen C, Nadstawek J, Wartenberg HC. Management of chronic orofacial pain: a survey of general dentists in German university hospitals. Pain Medicine 2010;11:416–24.
https://doi.org/10.1111/j.1526-4637.2010.00805.x
PMid:20447309

 

4. Smiljic S, Savic S, Stevanovic J, Kostic M. Prevalence and characteristics of orofacial pain in university students. J Oral Sci. 2016;58:7–13.
https://doi.org/10.2334/josnusd.58.7
PMid:27021534

 

5. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Oro-facial pain in the community: prevalence and associated impact. Community Dent Oral Epidemiol. 2000;30:52–60.
https://doi.org/10.1034/j.1600-0528.2002.300108.x

 

6. Tomoyasu Y, Higuchi H, Mori M, Takayaa K, Hondaa Y, Yamanea A, et al. Chronic orofacial pain in dental patients: retrospective investigation over 12 years. Acta Med Okayama. 2014;68:269–75.
PMid:25338483

 

7. Kimberly CL, Byers MR. Inflammation of rat molar pulp and periodontium causes increased calcitonin gene-related peptide and axonal sprouting. Anat Rec. 1988;222:289–300.
https://doi.org/10.1002/ar.1092220310
PMid:3265042

 

8. Gibbs JL, Urban R, Basbaum AI. Paradoxical surrogate markers of dental injury-induced pain in the mouse. Pain. 2013;154:1358–67.
https://doi.org/10.1016/j.pain.2013.04.018
PMid:23719574 PMCid:PMC3743260

 

9. Shang L, Xu TL, Li F, Su J, Li WG. Temporal dynamics of anxiety phenotypes in a dental pulp injury model. Mol Pain. 2015;11:40.
PMid:26122003 PMCid:PMC4487070

 

10. Chidiac JJ, Rifai K, Hawwa NN, Massaad CA, Jurjus AR, Jabbur SJ, et al. Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain. Eur J Pain. 2002;6:55–67.
https://doi.org/10.1053/eujp.2001.0305
PMid:11888229

 

11. Zecchin KG, da Silva Jorge R, Jorge J. A new method for extraction of mandibular first molars in rats. Braz J Oral Sci. 2007;6:1344–8.

 

12. Hikida T, Yamaguchi M, Shimizu M, Kikuta J, Yoshino T, Kasai K. Comparisons of orthodontic root resorption under heavy and jiggling reciprocating forces during experimental tooth movement in a rat model. Korean J Orthod. 2016;46:228–41.
https://doi.org/10.4041/kjod.2016.46.4.228
PMid:27478800 PMCid:PMC4965594

 

13. Sukhitashvili N, Imnadze I, Tabaghua G, Gogilashvili Q, Amiranashvili I. Characterization of oral ulcer and pathological scar in nude mice model. Georgian Med News. 2012;4:82–7.

 

14. Ito M, Ono K, Hitomi S, Nodai T, Sago T, Yamaguchi K, et al. Prostanoid-dependent spontaneous pain and PAR2-dependent mechanical allodynia following oral mucosal trauma: Involvement of TRPV1, TRPA1, and TRPV4. Mol Pain. 2017;13:1–17.
https://doi.org/10.1177/1744806917704138
PMid:28381109 PMCid:PMC5407658

 

15. Burgos E, Pascual D, Martín MI, Goicoechea C. Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests. Eur J Pain. 2010;14:40–8.
https://doi.org/10.1016/j.ejpain.2009.02.003
PMid:19318283

 

16. Hummig W, Kopruszinski CM, Chichorro JG. Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. J Oral Facial Pain Headache. 2014;28:350–9.
https://doi.org/10.11607/ofph.1317
PMid:25347171

 

17. Aczél T, Kun J, Szöke É, Rauch T, Junttila S, Gyenesei A, et al. Transcriptional alterations in the trigeminal ganglia, nucleus and peripheral blood mononuclear cells in a rat orofacial pain model. Front Mol Neursci. 2018;11:219.
https://doi.org/10.3389/fnmol.2018.00219
PMid:29997476 PMCid:PMC6028693

 

18. Jie HF, Yang GJ, Bi RY, Mo SY, Gan YH., Xie QF. Genistein antagonizes 17β-estradiol effects on glutamate-evoked masseter muscle hypernociception in rats. Front Neurol. 2018;9:649.
https://doi.org/10.3389/fneur.2018.00649
PMid:30166977 PMCid:PMC6106884

 

19. Sánchez EM, Bagües A, Martín MI. Contributions of peripheral and central opioid receptors to antinociception in rat muscle pain models. Pharmacol Biochem Behav. 2010;96:488–95.
https://doi.org/10.1016/j.pbb.2010.07.009
PMid:20637793

 

20. Romero-Reyes M, Akerman S, Nguyen E, Vijjeswarapu A, Hom B, Dong HW, et al. Spontaneous behavioral responses in the orofacial region: A model of trigeminal pain in mouse. Headache. 2013;53:137–51.
https://doi.org/10.1111/j.1526-4610.2012.02226.x
PMid:22830495 PMCid:PMC3664930

 

21. Bagüés A, Martín-Fontelles MI, Esteban-Hernández J, Sánchez-Robles EM. Characterization of the nociceptive effect of carrageenan: Masseter versus gastrocnemius. Muscle Nerve. 2017;56:804–13.
https://doi.org/10.1002/mus.25538
PMid:28026014

 

22. Huang F, Zhang M, Chen YJ, Li Q, Wu AZ. Psychological stress induces temporary masticatory muscle mechanical sensitivity in rats. J Biomed Biotechnol. 2011;2011:720603.
https://doi.org/10.1155/2011/720603
PMid:21331360 PMCid:PMC3035378

 

23. Wu YW, Bi YP, Kou XX, Xu W, Ma LQ, Wang KW, et al. 17-Beta-estradiol enhanced allodynia of inflammatory temporomandibular joint through upregulation of hippocampal TRPV1 in ovariectomized rats. J Neurosci. 2010;30:8710–9.
https://doi.org/10.1523/JNEUROSCI.6323-09.2010
PMid:20592193

 

24. Bereiter DA, Benetti AP. Excitatory amino release within spinal trigeminal nucleus after mustard oil injection into the temporomandibular joint region of the rat. Pain. 1996;67:451–9.
https://doi.org/10.1016/0304-3959(96)03156-9

 

25. Wang XD, Kou XX, He DQ, Zeng MM, Meng Z, Bi RY, et al. Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate. PLoS One. 2012;7:e45036.
https://doi.org/10.1371/journal.pone.0045036
PMid:22984604 PMCid:PMC3439407

 

26. Ferreira-Gomes J, Adães S, Mendonça M, Castro-Lopes JM. Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis. Pharmacol Biochem Behav. 2012;101:617–24.
https://doi.org/10.1016/j.pbb.2012.03.003
PMid:22426440

 

27. Vos BP, Strassman AM, Maciewicz RJ. Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve. J Neurosci. 1994;14:2708–23.
https://doi.org/10.1523/JNEUROSCI.14-05-02708.1994
PMid:8182437

 

28. Pozza DH, Castro-Lopes JM, Neto FL, Avelino A. Spared nerve injury model to study orofacial pain. Indian J Med Res 2016;143:297–302.
https://doi.org/10.4103/0971-5916.182619
PMid:27241642 PMCid:PMC4892075

 

29. Nakai K, Nakae A, Hashimoto R, Mashimo T, Hosokawa K. Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. J Oral Facial Pain Headache. 2014;28:61–7.
https://doi.org/10.11607/jop.1105
PMid:24482789

 

30. Ma F, Zhang L, Lyons D, Westlund KN. Orofacial neuropathic pain mouse model induced by trigeminal inflammatory compression (TIC) of the infraorbital nerve. Mol Brain. 2012;5:44.
https://doi.org/10.1186/1756-6606-5-44
PMid:23270529 PMCid:PMC3563613

 

31. Moran LB, Graeber MB. The facial nerve axotomy model. Brain Res Brain Res Rev. 2004;44:154-78.
https://doi.org/10.1016/j.brainresrev.2003.11.004
PMid:15003391

 

32. Cho GS, Han MW, Lee B, Roh JL, Choi SH, Cho KJ, et al. Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects. J Oral Pathol Med. 2010;39:722–7.
https://doi.org/10.1111/j.1600-0714.2010.00914.x
PMid:20618611

 

33. Suzuki R, Kohno H, Suzui M, Yoshimi N, Tsuda H, Wakabayashi K, et al. An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. Carcinogenesis. 2006;27:619–30.
https://doi.org/10.1093/carcin/bgi241
PMid:16219633

 

34. Schoop RAL, Noteborn MHM, de Jong RJB. A mouse model for oral squamous cell carcinoma. J Mol Hist. 2009;40:177–81.
https://doi.org/10.1007/s10735-009-9228-z
PMid:19685146 PMCid:PMC2770130

 

35. Ono K, Harano N, Inenaga K, Nakanishi O. A rat pain model of facial cancer. In: Luo Z.D. (ed.), Pain Research: Methods and Protocols, Methods in Molecular Biology, Springer. 2012;851:149–57.
https://doi.org/10.1007/978-1-61779-561-9_10
PMid:22351088

 

36. Ohne M, Satoh T, Yamada S, Takai H. Experimental tongue carcinoma of rats induced by oral administration of 4-nitro-quinoline 1-oxide (4NQO) in drinking water. Oral Surg Oral Med Oral Pathol. 1985;59:600–7.
https://doi.org/10.1016/0030-4220(85)90189-6

 

37. Tang XH, Knudsen B, Bemis D, Tickoo S, Gudas LJ. Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. Clin Cancer Res. 2004;10:301–13.
https://doi.org/10.1158/1078-0432.CCR-0999-3
PMid:14734483

 

38. Chodroff L, Bendele M, Valenzuela V, Henry M, Ruparel S. BDNF signaling contributes to oral cancer pain in a preclinical orthotopic rodent model. Mol Pain. 2016;12:1–17.
https://doi.org/10.1177/1744806916666841
PMid:27590070 PMCid:PMC5015823

 

39. Nagamine K, Ozaki N, Shinoda M, Asai H, Nishiguchi H, Mitsudo K, et al. Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats. J Pain. 2006;7:659–70.
https://doi.org/10.1016/j.jpain.2006.02.013
PMid:16942952