Marcela-Maria-Fontes Borges MMF, Malta CEN, Ribeiro RS, Cetira-Filho EL, Moura JFB, Rebouças LM, Costa FWG, Silva PGB, Mota MRL. Chemotherapy increases the prevalence of radiotherapy-related trismus in head and neck cancer patients: A systematic review and meta-analysis. J Clin Exp Dent. 2024;16(4):e503-15.

 

doi:10.4317/jced.61385

https://doi.org/10.4317/jced.61385

______

 

References

1. Guan J, Li Q, Zhang Y, Xiao N, Chen M, Zhang Y, et al. A meta-analysis comparing cisplatin-based to carboplatin-based chemotherapy in moderate to advanced squamous cell carcinoma of head and neck (SCCHN). Oncotarget. 2016;7:7110-7119.
https://doi.org/10.18632/oncotarget.6858
PMid:26755647 PMCid:PMC4872772

 

2. Zackrisson B, Mercke C, Strander H, Wennerberg J, Cavallin-Stahl E. A systematic overview of radiation therapy effects in head and neck cancer. Acta Oncologica. 2003;42:443-461.
https://doi.org/10.1080/02841860310014886
PMid:14596506

 

3. Silva PSLD, Leão VML, Scarpel RD. Characterizing the population with mouth and orofaringe cancer, attended in the sector of head and neck in a referral hospital in Salvador City-BA. Revista CEFAC. 2009;11:441-447.
https://doi.org/10.1590/S1516-18462009000700020

 

4. Skiba-Tatarska M, Kusa-Podkańska M, Surtel A, Wysokińska-Miszczuk J. The side-effects of head and neck tumors radiotherapy. Polskie Towarzystwo Lekarskie. 2016;41:47-49.

PMid:27734822

 

5. Mostel DD, Bauer RL, Lynch DP, Hwang ST. Oral complications in the treatment of cancer patients. Oral diseases. 2011;17:550-559.
https://doi.org/10.1111/j.1601-0825.2011.01788.x
PMid:21306481

 

6. Schutte HW, Heutink F, Wellenstein DJ, Broek GBVD, Hoogen FJA, Marres HAM, et al. Impact of Time to Diagnosis and Treatment in Head and Neck Cancer: a systematic review. Otolaryngology-Head And Neck Surgery. 2020;162:446-457.
https://doi.org/10.1177/0194599820906387
PMid:32093572

 

7. Langendijk JA. New developments in radiotherapy of head and neck cancer: higher precision with less patient discomfort? Radiotherapy and Oncology. 2007;85:1-6.
https://doi.org/10.1016/j.radonc.2007.07.019
PMid:17854932

 

8. Sher DJ, Thotakura V, Balboni TA, Norris CMJ, Haddad RI, Posner MR. Treatment of oral cavity squamous cell carcinoma with adjuvant or definitive intensity-modulated radiation therapy. International Journal of Radiation Oncology Biology Physics. 2011;81:e215-e222.
https://doi.org/10.1016/j.ijrobp.2011.02.023
PMid:21531515

 

9. Beitler JJ, Zhang Q, Fu KK, Trotti A, Spencer SA, Jones CU. Final Results of Local-Regional Control and Late Toxicity of RTOG 90-03; A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head And Neck Cancer. International journal of radiation oncology, biology, physics. 2014;89:13-20.
https://doi.org/10.1016/j.ijrobp.2013.12.027
PMid:24613816 PMCid:PMC4664465

 

10. Molin Y, Fayette J. Current chemotherapies for recurrent/metastatic head and neck cancer. Anti-cancer drugs. 2011;22:621-625.
https://doi.org/10.1097/CAD.0b013e3283421f7c
PMid:21131821

 

11. Carroll WR, Locher JL, Canon CL, Bohannon IA, Mccolloch NL, Magnuson JS. Pretreatment swallowing exercises improve swallow function after chemoradiation. The Laryngoscope. 2008;118:39-43.
https://doi.org/10.1097/MLG.0b013e31815659b0
PMid:17989581

 

12. Dijkstra PU, Huisman PM, Roodenburg JLN. Criteria for trismus in head and neck oncology. International journal of oral and maxillofacial surgery. 2006;35:337-342.
https://doi.org/10.1016/j.ijom.2005.08.001
PMid:16280237

 

13. Kraaijenga SAC, Oskam IM, Molen LVD, Hamming-Vrieze O, Hilgers FJM, Brekel MWMVD. Evaluation of long term (10-years+) dysphagia and trismus in patients treated with concurrent chemo-radiotherapy for advanced head and neck cancer. Oral oncology. 2015;51:787-794.
https://doi.org/10.1016/j.oraloncology.2015.05.003
PMid:26027851

 

14. Kamstra JL, Jager-Wittenaar H, Dijkstra PU, Huisman PM, Oort RPV, Laan BFAMVD et al. Oral symptoms and functional outcome related to oral and oropharyngeal cancer. Supportive Care in Cancer. 2011;19:1327-1333.
https://doi.org/10.1007/s00520-010-0952-4
PMid:20706851 PMCid:PMC3151373

 

15. Scott B, Butterworth C, Lowe D, Rogers SN. Factors associated with restricted mouth opening and its relationship to health-related quality of life in patients attending a Maxillofacial Oncology clinic. Oral oncology. 2008;44:430-438.
https://doi.org/10.1016/j.oraloncology.2007.06.015
PMid:17826305

 

16. Weber C, Dommerich S, Pau HW, Kramp B. Limited mouth opening after primary therapy of head and neck cancer. Oral and maxillofacial surgery. 2010;14:169-173.
https://doi.org/10.1007/s10006-010-0220-2
PMid:20358238

 

17. Stubblefield MD, Manfield L, Riedel ER. A preliminary report on the efficacy of a dynamic jaw opening device (dynasplint trismus system) as part of the multimodal treatment of trismus in patients with head and neck cancer. Archives of physical medicine and rehabilitation. 2010;91:1278-1282.
https://doi.org/10.1016/j.apmr.2010.05.010
PMid:20684911

 

18. Jham BC, Silva ARFD. Oral complications of radiotherapy in the head and neck. Brazilian journal of otorhinolaryngology. 2006;72:704-708.
https://doi.org/10.1016/S1808-8694(15)31029-6
PMid:17221065

 

19. Watters AL, Cope S, Keller MN, Padilla M, Enciso R. Prevalence of trismus in patients with head and neck cancer: A systematic review with meta-analysis. Head & neck. 2019;41:3408-3421.
https://doi.org/10.1002/hed.25836
PMid:31215723

 

20. Bonzanini LIL, Soldera EB, Ortigara GB., Schulz RE, Antoniazzi RP, Ardenghi TM, et al. Clinical and sociodemographic factors that affect the quality of life of survivors of head and neck cancer. Supportive Care in Cancer. 2020;28:1941-1950.
https://doi.org/10.1007/s00520-019-05008-4
PMid:31375906

 

21. Pauli N, Johnson J, Finizia C, Andrell P. The incidence of trismus and long-term impact on health-related quality of life in patients with head and neck cancer. Acta Oncologica. 2013;52:1137-1145.
https://doi.org/10.3109/0284186X.2012.744466
PMid:23193958

 

22. Johnson J, Johansson M, Rydén A, Houltz E, Finizia C. Impact of trismus on health-related quality of life and mental health. Head & Neck. 2015;37:1672-1679.
https://doi.org/10.1002/hed.23816
PMid:24985733

 

23. Humanes B, Camaño S, Lara JM, Sabbisetti V, González-Nicolás MÁ, Bonventre JV, et al. Cisplatin-induced renal inflammation is ameliorated by cilastatin nephroprotection. Nephrology Dialysis Transplantation. 2017;32:1645-1655.
https://doi.org/10.1093/ndt/gfx005
PMid:28340076 PMCid:PMC6251639

 

24. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. 2021;372:n71.
https://doi.org/10.1136/bmj.n71
PMid:33782057 PMCid:PMC8005924

 

25. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Systematic reviews. 2016;5:1-10.
https://doi.org/10.1186/s13643-016-0384-4
PMid:27919275 PMCid:PMC5139140

 

26. Schünemann H, Brożek J, Guyatt G, Oxman A. Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. Updated October. 2013.

 

27. Cardoso RC, Kamal M, Zaveri J, Chambers MS, Gunn GB, Fuller CD, et al. Self-Reported Trismus: prevalence, severity and impact on quality of life in oropharyngeal cancer survivorship: a cross-sectional survey report from a comprehensive cancer center. Supportive Care in Cancer. 2020;29:1825-1835.
https://doi.org/10.1007/s00520-020-05630-7
PMid:32779007 PMCid:PMC8790744

 

28. Jeremic G, Venkatesan V, Hallock A, Scott D, Hammond A, Read N, et al. Trismus following treatment of head and neck cancer. Journal of Otolaryngology--Head & Neck Surgery. 2011;40:323-9.

PMid:21777551

 

29. Lee LY, Chen SC, Chen WC, Huang BS, Lin CY. Postradiation trismus and its impact on quality of life in patients with head and neck cancer. Oral surgery, oral medicine, oral pathology and oral radiology. 2014;119:187-195.
https://doi.org/10.1016/j.oooo.2014.10.003
PMid:25487985

 

30. Lyons AJ, Crichton S, Pezier T. Trismus following radiotherapy to the head and neck is likely to have distinct genotype dependent cause. Oral oncology. 2013;49:932-936.
https://doi.org/10.1016/j.oraloncology.2013.05.009
PMid:23891529

 

31. Ou X, Zhou X, Shi Q, Xing X, Yang Y, Xu T, et al. Treatment outcomes and late toxicities of 869 patients with nasopharyngeal carcinoma treated with definitive intensity modulated radiation therapy: new insight into the value of total dose of cisplatin and radiation boost. Oncotarget. 2015;6:381-83.
https://doi.org/10.18632/oncotarget.5420
PMid:26485757 PMCid:PMC4742007

 

32. Morimoto M, Bijl HP, Schaaf AVD, Xu CJ, Steenbakkers RJ, Chouvalova O, et al. Development of normal tissue complication probability model for trismus in head and neck cancer patients treated with radiotherapy: The role of dosimetric and clinical factors. Anticancer research. 2019;39:6787-6798.
https://doi.org/10.21873/anticanres.13894
PMid:31810944

 

33. Steiner F, Evans J, Marsh R, Rigby P, James S, Sutherland K, et al. Mouth opening and trismus in patients undergoing curative treatment for head and neck cancer. International journal of oral and maxillofacial surgery. 2015;44:292-296.
https://doi.org/10.1016/j.ijom.2014.12.009
PMid:25577664

 

34. Strojan P, Hutcheson KA, Eisbruch A, Beitler JJ, Langendijk JA, Lee AW, et al. Treatment of late sequelae after radiotherapy for head and neck cancer. Cancer treatment reviews. 2017;59:79-92.
https://doi.org/10.1016/j.ctrv.2017.07.003
PMid:28759822 PMCid:PMC5902026

 

35. Wang CJ, Huang EY, Hsu HC, Chen HC, Fang FM, Hsiung CY. The degree and time-course assessment of radiation-induced trismus occurring after radiotherapy for nasopharyngeal cancer. The Laryngoscope. 2005;115:1458-1460.
https://doi.org/10.1097/01.mlg.0000171019.80351.46
PMid:16094124

 

36. Rao SD, Saleh ZH, Setton J, Tam M, McBride SM, Riaz N, et al. Dose-volume factors correlating with trismus following chemoradiation for head and neck cancer. Acta Oncologica. 2016;55:99-104.
https://doi.org/10.3109/0284186X.2015.1037864
PMid:25920361 PMCid:PMC4784420

 

37. Hague C, Beasley W, Garcez K, Lee LW, McPartlin A, McWilliam A, et al. Prospective evaluation of relationships between radiotherapy dose to masticatory apparatus and trismus. Acta Oncologica. 2018;57:1038-1042.
https://doi.org/10.1080/0284186X.2018.1459047
PMid:29630433

 

38. Bossi P, Bergamini C, Miceli R, Cova A, Orlandi E, Resteghini C, et al. Salivary Cytokine Levels and Oral Mucositis in Head and Neck Cancer Patients Treated With Chemotherapy and Radiation Therapy. International Journal Of Radiation Oncology Biology Physics. 2016;96:959-966.
https://doi.org/10.1016/j.ijrobp.2016.08.047
PMid:27745982

 

39. Logan RM, Stringer AM, Bowen JM, Gibson, Stephen TS, Keefe. Serum levels of NF-κB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biology & Therapy. 2008;7:1139-1145.
https://doi.org/10.4161/cbt.7.7.6207
PMid:18535404

 

40. Watters AL, Cope S, Keller MN, Padilla M. Prevalence of trismus in patients with head and neck cancer: A systematic review with meta-analysis. Head & neck. 2010;41:3408-3421.
https://doi.org/10.1002/hed.25836
PMid:31215723

 

41. Kraaijenga, SAC; Oskam, IM; Molen, LVD; Hamming-Vrieze, O; Hilgers, FJM & Brekel, MWMVD. Evaluation of long term (10-years+) dysphagia and trismus in patients treated with concurrent chemo-radiotherapy for advanced head and neck cancer. Oral oncology. 2015;51,787-794.
https://doi.org/10.1016/j.oraloncology.2015.05.003
PMid:26027851

 

42. Bensadoun RJ, Riesenbeck D, Lockhart PB, Elting LS, Spijkervet FK, Brennan MT. A systematic review of trismus induced by cancer therapies in head and neck cancer patients. Supportive Care in Cancer. 2010;18:1033-1038.
https://doi.org/10.1007/s00520-010-0847-4
PMid:20213237

 

43. Filho ELC, Carvalho FSR, Silva PGB, Barbosa DAF, Pereira KMA, Ribeiro TR, et al. Preemptive use of oral nonsteroidal anti-inflammatory drugs for the relief of inflammatory events after surgical removal of lower third molars: A systematic review with meta-analysis of placebo-controlled randomized clinical trials. Journal of Cranio-Maxillofacial Surgery. 2020;48:293-307.
https://doi.org/10.1016/j.jcms.2020.01.016
PMid:32070661

 

44. Ortigara GB, Schulz RE, Soldera EB, Bonzanini LIL, Danesi CC, Antoniazzi RP, et al. Association between trismus and dysphagia-related quality of life in survivors of head and neck cancer in Brazil. Oral surgery, oral medicine, oral pathology and oral radiology. 2019;128:235-242.
https://doi.org/10.1016/j.oooo.2019.05.009
PMid:31217081

 

45. Crowder SL, Douglas KG, Pepino MY, Sarma KP, Arthur AE. Nutrition impact symptoms and associated outcomes in post-chemoradiotherapy head and neck cancer survivors: a systematic review. Journal of Cancer Survivorship. 2018;12:479-494.
https://doi.org/10.1007/s11764-018-0687-7
PMid:29556926

 

46. Astradsson T, Laurell G, Ahlberg A, Nikolaidis P, Johansson H, Ehrsson YT. Trismus in patients with head and neck cancer and 5-year overall survival. Acta oto-laryngologica. 2018;138:1123-1127.
https://doi.org/10.1080/00016489.2018.1511059
PMid:30686104

 

47. Retèl VP, Molen LVD, Hilgers FJ, Rasch CR, l'Ortye AA, Steuten LM, Harten WHV. A cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy. BMC cancer. 2011;11:1-9.
https://doi.org/10.1186/1471-2407-11-475
PMid:22051143 PMCid:PMC3237585

 

48. Kamstra JI, Leeuwen MV, Roodenburg JL, Dijkstra PU. Exercise therapy for trismus secondary to head and neck cancer: a systematic review. Head & neck. 2017;39:2352-2362.
https://doi.org/10.1002/hed.24859
PMid:29044879