Sánchez-Pérez A, Palma-Sánchez A, Jornet-García A, Moya-Villaescusa MJ, Montoya-Carralero JM. Influence of age and sex on platelet count: Implications for optimizing growth factor-rich plasma preparation. J Clin Exp Dent. 2025;17(11):e1292-7.

doi:10.4317/jced.63137

___

References

1. Kawabata S, Akeda K, Yamada J, Takegami N, Fujiwara T, Fujita N, et al. Advances in platelet-rich plasma treatment for spinal diseases: a systematic review. Int J Mol Sci. 2023;24:7677. https://doi.org/10.3390/ijms24087677 PMid:37108837 PMCid:PMC10145581

2. Gupta S, Paliczak A, Delgado D. Evidence-based indications of platelet-rich plasma therapy. Expert Rev Hematol. 2021;1:97-108. https://doi.org/10.1080/17474086.2021.1860002 PMid:33275468

3. Paichitrojjana A, Paichitrojjana A. Platelet rich plasma and its use in hair regrowth: a review. Drug Des Devel Ther. 2022;16:635-45. https://doi.org/10.2147/DDDT.S356858 PMid:35300222 PMCid:PMC8922312

4. Cabrera-Ramírez JO, Puebla-Mora AG, González-Ojeda A, García-Martínez D, Cortés-Lares JA, Márquez-Valdés AR, et al. Platelet-rich plasma for the treatment of photodamage of the skin of the hands. Actas Dermosifiliogr. 2017;108(8):746-51. https://doi.org/10.1016/j.ad.2017.04.006 PMid:28625328

5. Magalon J, Chateau AL, Bertrand B, Louis ML, Silvestre A, Giraudo L, et al. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med. 2016;2(1):e000060. https://doi.org/10.1136/bmjsem-2015-000060 PMid:27900152 PMCid:PMC5117023

6. Anitua E, Fernández-de-Retana S, Alkhraisat MH. Platelet-rich plasma in oral and maxillofacial surgery from the perspective of composition. Platelets. 2021;32(2):174-82. https://doi.org/10.1080/09537104.2020.1856361 PMid:33350883

7. Miron RJ, Moraschini V, Fujioka-Kobayashi M, Zhang Y, Kawase T, Cosgarea R, et al. Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis. Clin Oral Investig. 2021;25(5):2461-78. https://doi.org/10.1007/s00784-021-03825-8 PMid:33609186 PMCid:PMC8060184

8. Guan S, Xiao T, Bai J, Ning C, Zhang X, Yang L, et al. Clinical application of platelet-rich fibrin to enhance dental implant stability: a systematic review and meta-analysis. Heliyon. 2023;9(2):e13196. https://doi.org/10.1016/j.heliyon.2023.e13196 PMid:36785817 PMCid:PMC9918761

9. Orrù V, Virdis F, Marongiu M, Serra V, Schlessinger D, Devoto M, et al. Effect of genetic factors, age and sex on levels of circulating extracellular vesicles and platelets. Int J Mol Sci. 2023;24(8):7183. https://doi.org/10.3390/ijms24087183 PMid:37108346 PMCid:PMC10138662

10. Hadley JB, Kelher MR, Coleman JR, Kelly KK, Dumont LJ, Esparza O, et al. Hormones, age, and sex affect platelet responsiveness in vitro. Transfusion. 2022;62(9):1882-93. https://doi.org/10.1111/trf.17054 PMid:35929193 PMCid:PMC9464702

11. Christakoudi S, Tsilidis KK, Evangelou E, Riboli E. Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort. Biol Sex Differ. 2023;14(1):12. https://doi.org/10.1186/s13293-023-00494-y PMid:36814334 PMCid:PMC9945692

12. Ranucci M, Aloisio T, Di Dedda U, Menicanti L, Vincentiis C, Baryshnikova E, et al. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019;14(11):e0225771. https://doi.org/10.1371/journal.pone.0225771 PMid:31774869 PMCid:PMC6881030

13. Zhang Y, Zhao B, Huang Z, Xie J, Zhou X, Fan C, et al. Sex-specific association between platelet content and bone mineral density in adults: a cross-sectional study. BMC Musculoskelet Disord. 2024;25:875. https://doi.org/10.1186/s12891-024-07963-4 PMid:39487471 PMCid:PMC11529332

14. Rossi L, Ranalletta M, Pasqualini I, Zicaro JP, Costa Paz M, Camino P, et al. Substantial variability in platelet-rich plasma composition is based on patient age and baseline platelet count. Arthrosc Sports Med Rehabil. 2023;5(3):e853-8. https://doi.org/10.1016/j.asmr.2023.03.017 PMid:37388884 PMCid:PMC10300586

15. Gaetano G, Bonaccio M, Cerletti C. How different are blood platelets from women or men, and young or elderly people? Haematologica. 2023;108(6):1473-5. https://doi.org/10.3324/haematol.2022.282131 PMid:36384253 PMCid:PMC10230435

16. Le Blanc J, Lordkipanidzé M. Platelet function in aging. Front Cardiovasc Med. 2019;6:109. https://doi.org/10.3389/fcvm.2019.00109 PMid:31448291 PMCid:PMC6692461

17. Kunapaisal T, Phuong J, Liu Z, Stansbury LG, Vavilala MS, Lele AV, et al. Age, admission platelet count, and mortality in severe isolated traumatic brain injury: a retrospective cohort study. Transfusion. 2023;63(8):1472-80. https://doi.org/10.1111/trf.17476 PMid:37515367

18. Cowman J, Dunne E, Oglesby I, Byrne B, Ralph A, Voisin B, et al. Age-related changes in platelet function are more profound in women than in men. Sci Rep. 2015;5:12235. https://doi.org/10.1038/srep12235 PMid:26179119 PMCid:PMC4503960

19. Biino G, Santimone I, Minelli C, Sorice R, Frongia B, Traglia M, et al. Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40,987 subjects' data. PLoS One. 2013;8(1):e54289. https://doi.org/10.1371/journal.pone.0054289 PMid:23382888 PMCid:PMC3561305

20. Gasecka A, Zimodro JM, Appelman Y. Sex differences in antiplatelet therapy: state-of-the-art. Platelets. 2023;34(1):2176173. https://doi.org/10.1080/09537104.2023.2176173 PMid:36809993

21. Chou YT, Chen HY, Wu IH, Su FL, Li WH, Hsu HL, et al. Higher platelet count, even within normal range, is associated with increased arterial stiffness in young and middle-aged adults. Aging (Albany NY). 2022;14(19):8061-70. https://doi.org/10.18632/aging.204335 PMid:36242594 PMCid:PMC9596195

22. Li X, Li N, Zhao G, Wang X. Effect of iron supplementation on platelet count in adult patients with iron deficiency anemia. Platelets. 2022;33(8):1214-9. https://doi.org/10.1080/09537104.2022.2091772 PMid:36050842

23. Khan MAN, Ghani U, Surani S, Aftab A. Vitamin B12 deficiency, a rare cause of isolated thrombocytopenia in adults. Cureus. 2023;15(8):e44162. https://doi.org/10.7759/cureus.44162

24. Nguyen T, et al. Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis. Blood. 2024;143(3):234-45.

25. Hashemzadeh M, Haseefa F, Peyton L, Park S, Movahed MR. The effects of estrogen and hormone replacement therapy on platelet activity: a review. Am J Blood Res. 2022;12(1):33-42. PMid:35291255 PMCid:PMC8918702

26. Yadav TS, Pandey G, Kumar G. Comparison of hematological profile of athletes in various phases of menstrual cycle. Asian Pac J Health Sci. 2022;9(3):218-22. https://doi.org/10.21276/apjhs.2022.9.3.44

27. Pang N, Li Y, Zhou K, Liu C, Yan R, Sun C, et al. Cyclic thrombocytopenia associated with estradiol: a case report. Hematology. 2023;28(1):2240140. https://doi.org/10.1080/16078454.2023.2240140 PMid:37493411