Borrás-Ferreres J, Boluda-Monzo S, Gay-Escoda C. Importance of the early diagnosis of acromegaly. Evolution ofmandibular growth and dental occlusion in a case with a late diagnosis. J Clin Exp Dent. 2025;17(12):e1544-9.

 

doi:10.4317/jced.63473

https://doi.org/10.4317/jced.63473

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References

1. De Stefani A, Dassie F, Wennberg A, Preo G, Muneratto A, Fabris R, Maffei P, Gracco A, Bruno G. Oral manifestations and maxillo-facial features in the acromegalic patient: A literature review. J Clin Med. 2022;11(4):1092.
https://doi.org/10.3390/jcm11041092
PMid:35207363 PMCid:PMC8878286

 

2. Herrmann BL, Mortsch F, Berg C, Weischer T, Mohr C, Mann K. Acromegaly: A cross-sectional analysis of the oral and maxillofacial pathologies. Exp Clin Endocrinol Diabetes. 2011;119(1):9-14.
https://doi.org/10.1055/s-0030-1255020
PMid:20658440

 

3. Kreitschmann-Andermahr I, Kohlmann J, Kleist B, Hirschfelder U, Buslei R, Buchfelder M, Siegel S. Oro-dental pathologies in acromegaly. Endocrine. 2018;60(2):323-8.
https://doi.org/10.1007/s12020-018-1571-y
PMid:29520625

 

4. Roumeau S, Thevenon J, Ouchchane L, Maqdasy S, Batisse-Lignier M, Duale C, Pham Dang N, Caron P, Tauveron I, Devoize L. Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study. Endocr Connect. 2020;9(8):824-33.
https://doi.org/10.1530/EC-20-0176
PMid:32738132 PMCid:PMC7487182

 

5. Matthesen AT, Rosendal C, Christensen EH, Beckmann H, Klit FØ, Nikontovic A, Bizik G, Vestergaard P, Dal J. Psychiatric morbidity in acromegaly: A cohort study and meta-analysis of the literature. Pituitary. 2025;28(2):42.
https://doi.org/10.1007/s11102-025-01509-0
PMid:40082297 PMCid:PMC11906539

 

6. Preo G, De Stefani A, Dassie F, Wennberg A, Vettor R, Maffei P, Gracco A, Bruno G. The role of the dentist and orthodontist in recognizing oro-facial manifestations of acromegaly: A questionnaire-based study. Pituitary. 2022;25(1):159-66.
https://doi.org/10.1007/s11102-021-01183-y
PMid:34518997 PMCid:PMC8821049

 

7. Scheithauer BW, Kovacs K, Randall RV, Horvath E, Laws ER Jr. Pathology of excessive production of growth hormone. Clin Endocrinol Metab. 1986;15(3):655-81.
https://doi.org/10.1016/S0300-595X(86)80014-7
PMid:3095005

 

8. Dineen R, Stewart PM, Sherlock M. Acromegaly. QJM. 2017;110(7):411-20.
https://doi.org/10.1093/qjmed/hcx171
PMid:29590494

 

9. Vilar L, Vilar CF, Lyra R, Lyra R, Naves LA. Acromegaly: Clinical features at diagnosis. Pituitary. 2017;20(1):22-32.
https://doi.org/10.1007/s11102-016-0772-8
PMid:27812777

 

10. Beckers A, Petrossians P, Hanson J, Daly AF. The causes and consequences of pituitary gigantism. Nat Rev Endocrinol. 2018;14(12):705-20.
https://doi.org/10.1038/s41574-018-0114-1
PMid:30361628

 

11. Chanson P, Salenave S, Kamenicky P, Cazabat L, Young J. Pituitary tumours: acromegaly. Best Pract Res Clin Endocrinol Metab. 2009;23(5):555-74.
https://doi.org/10.1016/j.beem.2009.05.010
PMid:19945023

 

12. Zahr R, Fleseriu M. Updates in diagnosis and treatment of acromegaly. Eur Endocrinol. 2018;14(2):57-61.
https://doi.org/10.17925/EE.2018.14.2.57
PMid:30349595 PMCid:PMC6182922

 

13. Holdaway IM, Rajasoorya C. Epidemiology of acromegaly. Pituitary. 1999;2(1):29-41.
https://doi.org/10.1023/A:1009965803750
PMid:11081170

 

14. Alhawyan FS. Mortality in acromegalic patients: Etiology, trends, and risk factors. Cureus. 2021;13(4):e14265.
https://doi.org/10.7759/cureus.14265
PMid:33959447 PMCid:PMC8093096

 

15. Ságová I, Bolek T, Dragula M, Péč MJ, Benko J, Jurica J, Tonhajzerová I, Kantárová D, Mokáň M, Vaňuga P, Samoš M. Effects of treatment on structural and functional parameters of the left heart in naïve acromegaly patients: Prospective single-centre study: 12-month follow-up. J Clin Med. 2025;14(10):3397.
https://doi.org/10.3390/jcm14103397
PMid:40429391 PMCid:PMC12112557

 

16. Iglesias P. Acromegaly and cardiovascular disease: Associated cardiovascular risk factors, cardiovascular prognosis, and therapeutic impact. J Clin Med. 2025;14(6):1906.
https://doi.org/10.3390/jcm14061906
PMid:40142714 PMCid:PMC11943432

 

17. Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis. 2008;3:17.
https://doi.org/10.1186/1750-1172-3-17
PMid:18578866 PMCid:PMC2459162

 

18. Caulley L, Quinn JG, Doyle MA, Alkherayf F, Metzendorf MI, Kilty S, Hunink MGM. Surgical and non-surgical interventions for primary and salvage treatment of growth hormone-secreting pituitary adenomas in adults. Cochrane Database Syst Rev. 2024;2(2):CD013561.
https://doi.org/10.1002/14651858.CD013561.pub2
PMid:38318883 PMCid:PMC10845214

 

19. Zhou N, Ho JTF, De Vries N, De Lange J. Obstructive sleep apnea caused by acromegaly: Case report. Cranio. 2022;40(5):451-3.
https://doi.org/10.1080/08869634.2020.1776530
PMid:32485132

 

20. Agrawal M, Maitin N, Rastogi K, Bhushan R. Seeing the unseen: Diagnosing acromegaly in a dental setup. BMJ Case Rep. 2013;3:bcr2013200266.
https://doi.org/10.1136/bcr-2013-200266
PMid:24001731 PMCid:PMC3794153

 

21. Kasuki L, Rocha PDS, Lamback EB, Gadelha MR. Determinants of morbidities and mortality in acromegaly. Arch Endocrinol Metab. 2019;63(6):630-7.
https://doi.org/10.20945/2359-3997000000193
PMid:31939488 PMCid:PMC10522229

 

22. Petrossians P, Daly AF, Natchev E, Maione L, Blijdorp K, Sahnoun-Fathallah M, Auriemma R, Diallo AM, Hulting AL, Ferone D, Hana V Jr, Filipponi S, Sievers C, Nogueira C, Fajardo-Montañana C, Carvalho D, Hana V, Stalla GK, Jaffrain-Réa ML, Delemer B, Colao A, Brue T, Neggers SJCMM, Zacharieva S, Chanson P, Beckers A. Acromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) Database. Endocr Relat Cancer. 2017;24(10):505-18.
https://doi.org/10.1530/ERC-17-0253
PMid:28733467 PMCid:PMC5574208

 

23. Aydin K, Cınar N, Dagdelen S, Erbas T. Diagnosis of acromegaly: Role of the internist and the other medical professionals. Eur J Intern Med. 2014;25(2):e25-6.
https://doi.org/10.1016/j.ejim.2013.09.014
PMid:24157180

 

24. Keskin FE, Yetkin DO, Ozkaya HM, Haliloglu O, Sadri S, Gazioglu N, Tanrıover N, Ak H, Hatipoglu E, Kadıoglu P. The problem of unrecognized acromegaly: Surgeries patients undergo prior to diagnosis of acromegaly. J Endocrinol Invest. 2015;38(6):695-700.
https://doi.org/10.1007/s40618-015-0245-3
PMid:25716208

 

25. Zarool-Hassan R, Conaglen HM, Conaglen JV, Elston MS. Symptoms and signs of acromegaly: An ongoing need to raise awareness among healthcare practitioners. J Prim Health Care. 2016;8(2):157-63.
https://doi.org/10.1071/HC15033
PMid:27477558