Gil-Morales J, Galletti C, Flores-Fraile J, Greethurst AR, Galletti F, Real-Voltas F. Evaluation of alveolar ridge preservation using collagen and platelet-rich fibrin: A systematic review. J Clin Exp Dent. 2026;18(3):e402-12.

 

doi:10.4317/jced.63789

https://doi.org/10.4317/jced.63789

___

 

References

1. Tan WL, Wong TLT, Wong MCM, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012;23 Suppl 5:1-21.
https://doi.org/10.1111/j.1600-0501.2011.02375.x
PMid:22211303

 

2. Avila-Ortiz G, Rodriguez J, Rudek I, Benavides E, Rios H, Wang HL. Effectiveness of three different alveolar ridge preservation techniques: a pilot randomized controlled trial. Int J Periodontics Restorative Dent. 2014;34[4]:509-21.
https://doi.org/10.11607/prd.1838
PMid:25006768

 

3. Darby I, Chen S, De Poi R. Ridge preservation: what is it and when should it be considered. Aust Dent J. 2008;53[1]:11-21.
https://doi.org/10.1111/j.1834-7819.2007.00008.x
PMid:18304236

 

4. Gadhia A, Pepper T. Oral surgery, extraction of teeth. StatPearls. 2023.

 

5. Pietrokovski J, Massler M. Alveolar ridge resorption following tooth extraction. J Prosthet Dent. 1967;17[1]:21-7.
https://doi.org/10.1016/0022-3913(67)90046-7
PMid:5224784

 

6. Juodzbalys G, Stumbras A, Goyushov S, Duruel O, Tözüm TF. Morphological classification of extraction sockets and clinical decision tree for socket preservation/augmentation after tooth extraction: a systematic review. J Oral Maxillofac Res. 2019;10[3].
https://doi.org/10.5037/jomr.2019.10303

 

7. Vittorini Orgeas G, Clementini M, De Risi V, de Sanctis M. Surgical techniques for alveolar socket preservation: a systematic review. Int J Oral Maxillofac Implants. 2013;28[4]:1049-61.
https://doi.org/10.11607/jomi.2670
PMid:23869363

 

8. Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003;23[4]:313-23.

 

9. Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction: an experimental study in the dog. J Clin Periodontol. 2005;32[2]:212-8.
https://doi.org/10.1111/j.1600-051X.2005.00642.x
PMid:15691354

 

10. Barootchi S, Tavelli L, Majzoub J, Stefanini M, Wang HL, Avila-Ortiz G. Alveolar ridge preservation: complications and cost-effectiveness. Periodontol 2000. 2023;92[1]:235-62.
https://doi.org/10.1111/prd.12469
PMid:36580417

 

11. Gabay E, Katorza A, Zigdon-Giladi H, Horwitz J, Machtei EE. Histological and dimensional changes of the alveolar ridge following tooth extraction when using collagen matrix and collagen-embedded xenogenic bone substitute: a randomized clinical trial. Clin Implant Dent Relat Res. 2022;24[3]:382-90.
https://doi.org/10.1111/cid.13085
PMid:35298865 PMCid:PMC9310752

 

12. Rodrigues MTV, Guillen GA, Macêdo FGC, Goulart DR, Nóia CF. Comparative effects of different materials on alveolar preservation. J Oral Maxillofac Surg. 2023;81[2]:213-23.
https://doi.org/10.1016/j.joms.2022.10.008
PMid:36400157

 

13. Abad CE, Sanz-Sanchez I, Serrano V, Sanz Esporrin J, Sanz-Martin I, Sanz M. Efficacy of the application of leukocyte and platelet-rich fibrin (L-PRF) on alveolar ridge preservation: a randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023;25[3]:592-604.
https://doi.org/10.1111/cid.13208
PMid:37088697

 

14. Tortolini P, Rubio S. Different alternatives of bone grafts. Av Periodoncia Implantol Oral. 2012;24[3]:133-8.
https://doi.org/10.4321/S1699-65852012000300003

 

15. Anitua E, Sánchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28[31]:4551-60.
https://doi.org/10.1016/j.biomaterials.2007.06.037
PMid:17659771 PMCid:PMC9598782

 

16. Natto ZS, Paul B, Deeb GR, Ganguly R, Finkelman MD, Jeong YN. Efficacy of collagen matrix seal and collagen sponge on ridge preservation in combination with freeze-dried bone allograft: a randomized clinical trial. Clin Oral Implants Res. 2017;30(S19):455.

 

17. Natto ZS, Parashis A, Steffensen B, Ganguly R, Finkelman MD, Jeong YN. Efficacy of collagen matrix seal and collagen sponge on ridge preservation in combination with bone allograft: a randomized controlled clinical trial. J Clin Periodontol. 2017;44[6]:649-59.
https://doi.org/10.1111/jcpe.12722
PMid:28303642

 

18. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372.
https://doi.org/10.1136/bmj.n71
PMid:33782057 PMCid:PMC8005924

 

19. Haddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev. 2022;18[2].
https://doi.org/10.1002/cl2.1230
PMid:36911350 PMCid:PMC8958186

 

20. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366.
https://doi.org/10.1136/bmj.l4898
PMid:31462531

 

21. Eeckhout C, Seyssens L, Glibert M, Keppens L, Nollet B, Lambert M, et al. A randomized controlled trial comparing collagen matrix to hemostatic gelatin sponge as socket seal in alveolar ridge preservation. J Clin Med. 2024;13[8]:2293.
https://doi.org/10.3390/jcm13082293
PMid:38673566 PMCid:PMC11051156

 

22. Lahham C, Ta'a MA, Lahham E, Michael S, Zarif W. The effect of recurrent application of concentrated platelet-rich fibrin inside the extraction socket on the hard and soft tissues: a randomized controlled trial. BMC Oral Health. 2023;23[1]:677.
https://doi.org/10.1186/s12903-023-03400-5
PMid:37726689 PMCid:PMC10507883

 

23. Areewong K, Chantaramungkorn M, Khongkhunthian P. Platelet-rich fibrin to preserve alveolar bone sockets following tooth extraction: a randomized controlled trial. Clin Implant Dent Relat Res. 2019;21[6]:1156-63.
https://doi.org/10.1111/cid.12846
PMid:31647177

 

24. Anitua E, Murias-Freijo A, Alkhraisat MH, Orive G. Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial. Clin Oral Investig. 2015;19[3]:589-600.
https://doi.org/10.1007/s00784-014-1278-2
PMid:24998770

 

25. Anderud J, Lennholm C, Wälivaara DÅ. Ridge preservation using Collacone compared with an empty socket: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021;132[2]:e55-61.
https://doi.org/10.1016/j.oooo.2021.01.012
PMid:33741284

 

26. Kim JW, Seong TW, Cho S, Kim SJ. Randomized controlled trial on the effectiveness of absorbable collagen sponge after extraction of impacted mandibular third molar: split-mouth design. BMC Oral Health. 2020;20[5].
https://doi.org/10.1186/s12903-020-1063-3
PMid:32183831 PMCid:PMC7079387

 

27. Alasqah M, Alansary RD, Gufran K. Efficacy of platelet-rich fibrin in preserving alveolar ridge volume and reducing postoperative pain in site preservation of post-extracted sockets. Medicina (Kaunas). 2024;60[7].
https://doi.org/10.3390/medicina60071067
PMid:39064496 PMCid:PMC11278985

 

28. Llanos AH, Sapata VM, Jung RE, Hämmerle CH, Thoma DS, César Neto JB, et al. Comparison between two bone substitutes for alveolar ridge preservation after tooth extraction: cone-beam computed tomography results of a non-inferiority randomized controlled trial. J Clin Periodontol. 2019;46[3]:373-81.
https://doi.org/10.1111/jcpe.13079
PMid:30710389

 

29. Maiorana C, Poli PP, Deflorian M, Testori T, Mandelli F, Nagursky H, et al. Alveolar socket preservation with demineralised bovine bone mineral and a collagen matrix. J Periodontal Implant Sci. 2017;47[4]:194-210.
https://doi.org/10.5051/jpis.2017.47.4.194
PMid:28861284 PMCid:PMC5577438

 

30. Afifi A, Alqutaibi AY, Al-Hamdan RS, Alshahrani S, Alsharif M, Al-Kheraif AA. Clinical and radiographic evaluation of platelet-rich fibrin versus free gingival graft for alveolar ridge preservation: a randomized clinical trial. Int Dent J. 2025;75[1]:123-31.

 

31. Khan J, Bandi S, Gangineni S, Kummari S, Pradeep DG, Hinduja T. Evaluation of alveolar ridge dimensions by socket preservation therapy using a bone graft and platelet-rich fibrin: a randomized controlled trial. Cureus. 2024;16[5]:e60388.
https://doi.org/10.7759/cureus.60388

 

32. Meloni SM, Tallarico M, Pisano M, Xhanari E, Canullo L. Socket sealing with epithelial connective tissue graft versus porcine collagen matrix after ridge preservation with deproteinized bovine bone: a randomized controlled clinical trial. Eur J Oral Implantol. 2015;8[1]:39-48.

 

33. Iorio-Siciliano V, Blasi A, Nicolò M, Iorio-Siciliano A, Riccitiello F, Ramaglia L. Clinical outcomes of socket preservation using bovine-derived xenograft collagen and collagen membrane post-tooth extraction: a 6-month randomized controlled clinical trial. Int J Periodontics Restorative Dent. 2017;37[5]:e290-6.
https://doi.org/10.11607/prd.2474
PMid:28817143