Plaza-Matos E, López-Vicente J, Larrea-Rodríguez N, Alberdi-Navarro J. Appearance of necrotizing sialometaplasia temporarily associated with mdma consumption. J Clin Exp Dent. 2026;18(3):e420-3.

doi:10.4317/jced.63836

https://doi.org/10.4317/jced.63836

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References

1. Abrams A, Melrose RJ, Howell FV. Necrotizing sialometaplasia. A disease simulating malignancy. Cancer. 1973;32:130-5. https://doi.org/10.1002/1097-0142(197307)32:1<130::AID-CNCR2820320118>3.0.CO;2-8 PMid:4716764

2. Muller S, Tilakaratne WM. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue. Head Neck Pathol. 2022;16:54-62. https://doi.org/10.1007/s12105-021-01402-9 PMid:35312982 PMCid:PMC9018914

3. Nerí dos SV, Silva VP da, Araújo NS, Gomes TAO, Narcimento MB do, Cangusso MCT, et al. Necrotizing sialometaplasia: systematic review and meta analyses over the past 46 years. J Oral Diag. 2024;9:1-10. https://doi.org/10.5935/2525-5711.20230232

4. Brannon RB, Fowler CB, Hartman KS. Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review of the literature. Oral Surg, Oral Med Oral Pathol. 1991;72:317-25. https://doi.org/10.1016/0030-4220(91)90225-2 PMid:1923419

5. Kaplan I, Alterman M, Kleinman S, Reiser V, Shuster A, Dagan Y, et al. The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:577-85. https://doi.org/10.1016/j.oooo.2012.02.020 PMid:22921832

6. Domah F, Shah R. The role of ischaemia in necrotising sialometaplasia. Oral Surg. 2017;10:117-123. https://doi.org/10.1111/ors.12223

7. Yoshimoto S, Yada N, Ishikawa A, Kawano K, Matsuo K, Hiraki A, et al. TGF-β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia. J Pathol. 2024;263:338-346. https://doi.org/10.1002/path.6287 PMid:38594209

8. Yoshimoto S, Yada N, Ishikawa A, Kawano K, Matsuo K, Hiraki A, et al. Hypoxia contributes to the early-stage progression of necrotizing sialometaplasia. Am J Pathol. 2025;195:1074-1084. https://doi.org/10.1016/j.ajpath.2025.01.015 PMid:40056976

9. Close LG, Cowan DF. Recurrent necrotizing sialometaplasia of the nasal cavity. Otoryngol Head Neck Surg. 1985;93:422-5. https://doi.org/10.1177/019459988509300326 PMid:3927243

10. Broadley KJ. The vascular effects of trace amines and amphetamines. Pharmacol Ther. 2010;125:363-75. https://doi.org/10.1016/j.pharmthera.2009.11.005 PMid:19948186

11. Fonseca DA, Ribeiro DM, Tapadas M, Cotrim MD. Ecstasy (3,4-methylenedioxymethamphetamine): Cardiovascular effects and mechanisms. Eur J Pharmacol. 2021;903:e174156. https://doi.org/10.1016/j.ejphar.2021.174156 PMid:33971177

12. Biancardi MR, Da Silveira HA, Fernandes D, De Almeida LY, Ortega RM, León JE, et al. Ecstasy abuse and its effects on the oral mucosa. J Craniofac Surg. 2019;30:189-91. https://doi.org/10.1097/SCS.0000000000005033 PMid:30882567

13. Ahmed M, Islam S, Hoffman GR. Widespread oral and oropharyngeal mucosal oedema induced by ecstasy (MDMA): A case for concern. Br J Oral Maxillofac Surg. 2007;45:496-8. https://doi.org/10.1016/j.bjoms.2007.04.002 PMid:17559993

14. da Silveira Teixeira D, de Figueiredo MAZ, Cherubini K, de Oliveira SD, Salum FG. The topical effect of chlorhexidine and povidone-iodine in the repair of oral wounds. A review. Stomatologija. 2019;21(2):35-41. PMid:32108654

15. Monteiro MA, Andrade Rios da Silva L, Sousa-Neto SS, Albuquerque-Júnior RLC, Nonaka CFW, Alves PM, et al. Oral Ulceration with Bone Sequestration: Key Insights for Clinicians and Their Relevance in Contemporary Clinical Practice-A Narrative Systematic Review. Healthcare (Basel). 2025;13:1350. https://doi.org/10.3390/healthcare13111350 PMid:40508963 PMCid:PMC12154502