Friedlander AH, López-López J, Velasco-Ortega E. Diagonal Ear Lobe Crease and Atherosclerosis: Diagonal ear lobe crease and atherosclerosis: A review of the medical literature and dental implications. Med Oral Patol Oral Cir Bucal. 2012 Jan 1;17 (1):e153-9.

 

doi:10.4317/medoral.17390

http://dx.doi.org/doi:10.4317/medoral.17390

 

 

1. World Health Organization. Mortality Country Fact Sheet 2006: Spain. http://www.who.int/whosis/mort/profiles/mort_euro_esp_spain.pdf [Accessibility verified August 13, 2010].

2. Marzolo M, Verlato F, Zotta L, Guadagnin ML, Borgese L, Cravatari M, et al. Occult atherosclerosis and physical vascular examination: a simple strategy to avoid inadequate cardiovascular prevention and under-use of diagnostic vascular guidelines in outpatients. A multicenter study by Angiology Care Units in North-Eastern Italy. Int Angiol. 2008;27:426-32.
PMid:18974707

3. Menotti A, Giampaoli S, Seccareccia F. The relationship of cardiovascular risk factors measured at different ages to prediction of all-cause mortality and longevity. Arch Gerontol Geriatr. 1998;26:99-111.
http://dx.doi.org/10.1016/S0167-4943(97)00035-6

4.
Frank ST. Aural sign of coronary-artery disease. N Engl J Med. 1973;289:327-8.
http://dx.doi.org/10.1056/NEJM197308092890622

5.
Petrakis NL. Diagonal earlobe creases, type A behavior and the death of Emperor Hadrian. West J Med. 1980;132:87-91.
PMid:6990626    PMCid:1271965

6. Lichstein E, Chadda KD, Naik D, Gupta PK. Diagonal ear-lobe crease: prevalence and implications as a coronary risk factor. N Engl J Med. 1974;290:615-6.
http://dx.doi.org/10.1056/NEJM197403142901109
PMid:4812503

7. Kaukola S. The diagonal ear-lobe crease, a physical sign associated with coronary heart disease. Acta Med Scand Suppl. 1978;619:1-49.
PMid:279228

8. Kaukola S, Manninen V, Valle M, Halonen PI. Ear-lobe crease and coronary atherosclerosis.Lancet. 1979;2:1377.
http://dx.doi.org/10.1016/S0140-6736(79)92868-X

9.
Christiansen JS, Mathiesen B, Andersen AR, Calberg H. Letter: Diagonal ear-lobe crease in coronary heart disease. N Engl J Med. 1975;293:308-9.
http://dx.doi.org/10.1056/NEJM197508072930626

10.
Nyboe J, Jensen G, Appleyard M, Schnohr P. Risk factors for acute myocardial infarction in Copenhagen. I: Hereditary, educational and socioeconomic factors. Copenhagen City Heart Study. Eur Heart J. 1989;10:910-6.
PMid:2598948

11. Evrengül H, Dursunoğlu D, Kaftan A, Zoghi M, Tanriverdi H, Zungur M, et al. Bilateral diagonal earlobe crease and coronary artery disease: a significant association. Dermatology. 2004;209:271-5.
http://dx.doi.org/10.1159/000080847

12.
Toyosaki N, Tsuchiya M, Hashimoto T, Kawasaki K, Shiina A, Toyooka T, et al. Earlobe crease and coronary heart disease in Japanese. Heart Vessels. 1986;2:161-5.
http://dx.doi.org/10.1007/BF02128142
PMid:3793668

13. Elliott WJ, Karrison T. Increased all-cause and cardiac morbidity and mortality associated with the diagonal earlobe crease: a prospective cohort study. Am J Med. 1991;91:247-54.
http://dx.doi.org/10.1016/0002-9343(91)90123-F

14.
Patel V, Champ C, Andrews PS, Gostelow BE, Gunasekara NP, Davidson AR. Diagonal earlobe creases and atheromatous disease: a postmortem study. J R Coll Physicians Lond. 1992;26:274-7.
PMid:1404022

15. Kirkham N, Murrells T, Melcher DH, Morrison EA. Diagonal earlobe creases and fatal cardiovascular disease: a necropsy study. Br Heart J. 1989;61:361-4.
http://dx.doi.org/10.1136/hrt.61.4.361

16.
Edston E. The earlobe crease, coronary artery disease, and sudden cardiac death: an autopsy study of 520 individuals. Am J Forensic Med Pathol. 2006;27:129-33.
http://dx.doi.org/10.1097/01.paf.0000221067.73173.d7
PMid:16738431

17. Petrakis NL, Koo L. Earlobe crease. Lancet. 1980;1:376.
http://dx.doi.org/10.1016/S0140-6736(80)90930-7

18.
Merlob P, Amir J, Reisner SH. Diagonal earlobe crease in newborn infants and in children. Clin Pediatr (Phila). 1981;20:739-40.

19. Moncada B, Ruíz JM, Rodríguez E, Leiva JL.
Ear-lobe crease.Lancet. 1979;1:220-1.
http://dx.doi.org/10.1016/S0140-6736(79)90629-9

20.
Kristensen BO. Ear-lobe crease and vascular complications in essential hypertension.Lancet. 1980;1:265.
http://dx.doi.org/10.1016/S0140-6736(80)90761-8

21.
Doering C, Ruhsenberger C, Phillips DS. Ear lobe creases and heart disease. J Am Geriatr Soc. 1977;25:183-5.
PMid:845360

22. Raman R, Rani PK, Kulothungan V, Sharma T. Diagonal ear lobe crease in diabetic south Indian population: is it associated with Diabetic Retinopathy?. Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular-genetics Study (SN-DREAMS, Report no. 3). BMC Ophthalmol. 2009;9:11.
http://dx.doi.org/10.1186/1471-2415-9-11
PMid:19788727    PMCid:2762956

23. Mehta J, Hamby RI. Letter: Diagonal ear-lobe crease as a coronary risk factor. N Engl J Med. 1974;291:260.
http://dx.doi.org/10.1056/NEJM197408012910518

24.
Cheng TO. More research needed on the association between diagonal earlobe crease and coronary artery disease. Arch Intern Med. 2000;160:2396-7.
http://dx.doi.org/10.1001/archinte.160.15.2396
PMid:10927744

25. Kenny DJ, Gilligan D. Ear lobe crease and coronary artery disease in patients undergoing coronary arteriography. Cardiology. 1989;76:293-8.
http://dx.doi.org/10.1159/000174506
PMid:2805016

26. Brady PM, Zive MA, Goldberg RJ, Gore JM, Dalen JE. A new wrinkle to the earlobe crease. Arch Intern Med. 1987;147:65-6.
http://dx.doi.org/10.1001/archinte.1987.00370010069017
PMid:3800532

27. Kuon E, Pfahlbusch K, Lang E. The diagonal ear lobe crease for evaluating coronary risk.Z Kardiol. 1995;84:512-9.
PMid:7676721

28. Koracevic G, Atanaskovic V. Ear lobe crease: point of disagreement in evidence-based medicine. Am J Forensic Med Pathol. 2009;30:89.
http://dx.doi.org/10.1097/PAF.0b013e3181873c48
PMid:19237867

29.
Bouissou H, Pieraggi MT, Julian M, Pendaries I, Seguier J, Salvador M, et al. Value of skin biopsy in coronary insufficiency]. Arch Mal Coeur Vaiss. 1973;66:655-60.
PMid:4199981

30. Higuchi Y, Maeda T, Guan JZ, Oyama J, Sugano M, Makino N. Diagonal earlobe crease are associated with shorter telomere in male Japanese patients with metabolic syndrome. Circ J. 2009;73:274-9.
http://dx.doi.org/10.1253/circj.CJ-08-0267
PMid:19060421

31. Celik S, Erdoğan T, Gedikli O, Kiriş A, Erem C. Diagonal ear-lobe crease is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease. Atherosclerosis. 2007;192:428-31.
http://dx.doi.org/10.1016/j.atherosclerosis.2006.08.042
PMid:17027992

32. Shrestha I, Ohtsuki T, Takahashi T, Nomura E, Kohriyama T, Matsumoto M. Diagonal ear-lobe crease is correlated with atherosclerotic changes in carotid arteries. Circ J. 2009;73:1945-9.
http://dx.doi.org/10.1253/circj.CJ-09-0141
PMid:19644217

33. Touboul PJ, Hernández-Hernández R, Küçükoğlu S, Woo KS, Vicaut E, Labreuche J, et al. Carotid artery intima media thickness, plaque and Framingham cardiovascular score in Asia, Africa/Middle East and Latin America: the PARC-AALA study. Int J Cardiovasc Imaging. 2007;23:557-67.
http://dx.doi.org/10.1007/s10554-006-9197-1
PMid:17186134

34. Friedlander AH. Association between clinically identified diagonal earlobe creases and calcified carotid artery atheromas evidenced on panoramic radiography. J Oral Maxillofac Surg. 2010;68:227-8.
http://dx.doi.org/10.1016/j.joms.2009.06.041
PMid:20006184

35. Bahcelioglu M, Isik AF, Demirel B, Senol E, Aycan S. The diagonal ear-lobe crease.As sign of some diseases. Saudi Med J. 2005;26:947-51.
PMid:15983680

36. Friedlander AH, Cohen SN. Panoramic radiographic atheromas portend adverse vascular events. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:830-5.
http://dx.doi.org/10.1016/j.tripleo.2006.07.016
PMid:17261373

37. Kotsis VT, Pitiriga VCh, Stabouli SV, Papamichael CM, Toumanidis ST, Rokas SG, et al. Carotid artery intima-media thickness could predict the presence of coronary artery lesions. Am J Hypertens. 2005;18:601-6.
http://dx.doi.org/10.1016/j.amjhyper.2004.11.019
PMid:15882541

38. Rohani M, Jogestrand T, Ekberg M, van der Linden J, Källner G, Jussila R, et al. Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease. Atherosclerosis. 2005;179:311-6.
http://dx.doi.org/10.1016/j.atherosclerosis.2004.10.012
PMid:15777547

39. Johnsen SH, Mathiesen EB. Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease. Curr Cardiol Rep. 2009;11:21-7.
http://dx.doi.org/10.1007/s11886-009-0004-1

40.
Guţiu IA, Galeţescu E, Guţiu LI, Răducu L. Diagonal earlobe crease: a coronary risk factor, a genetic marker of coronary heart disease, or a mere wrinkle. Ancient Greco-Roman evidence. Rom J Intern Med. 1996;34:271-8.
PMid:9167228