Rodríguez-Pérez M, Bravo-Pérez M, Sánchez-López JD, Muñoz-Soto E, Romero-Olid MN, Baca-García P. Effectiveness of 1% versus 0.2% chlorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: A randomized, double-blind clinical trial. Med Oral Patol Oral Cir Bucal. 2013 Jul 1;18 (4):e693-700.

doi:10.4317/medoral.18702

http://dx.doi.org/doi:10.4317/medoral.18702

1. Colby RC. The general practitioner's perspective of the etiology, prevention, and treatment of dry socket. Gen Dent. 1997;45:461-7.
PMid:9515413

2. Shugars DA, Benson K, White RP, Simpson KN, Bader JD. Developing a measure of patient perceptions of short-term outcomes of third molar surgery. J Oral Maxillofac Surg. 1996;54:1402-8.
http://dx.doi.org/10.1016/S0278-2391(96)90253-0

3. Blum IR. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, etiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002;31:309-17.
http://dx.doi.org/10.1054/ijom.2002.0263
PMid:12190139

4. Hedström L, Sjögren P. Effect estimates and methodological quality of randomized controlled trials about prevention of alveolar osteítis following tooth extraction: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:8-15.
http://dx.doi.org/10.1016/j.tripleo.2006.01.007
PMid:17178488

5. Birn H. Antifibrinolytic effect of Apernyl in "dry socket". Int J Oral Surg. 1972;1:190-4.
http://dx.doi.org/10.1016/S0300-9785(72)80012-7

6. Penarocha M, Sanchís JM, Sáez U, Gay C, Bagán JV. Oral higiene and postoperative pain after mandibular third molar surgery. Oral surg Oral Med Oral Pathol Radiol Endod. 2001;92:260-4.
http://dx.doi.org/10.1067/moe.2001.115722
PMid:11552141

7. Malkawi Z, Al-Omiri MK, Khraisat A. Risk indicators of postoperative complications following surgical extraction of lower third molars. Med Princ Pract. 2011;20:321-5.
http://dx.doi.org/10.1159/000324550
PMid:21576990

8. Cardoso CL, Rodrigues MT, Ferreira Júnior O, Garlet GP, de Carvalho PS. Clinical concepts of dry socket. J Oral Maxillofac Surg. 2010;68:1922-32.
http://dx.doi.org/10.1016/j.joms.2009.09.085
PMid:20537783

9. Caso A, Hung LK, Beirne OR. Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:155-9.
http://dx.doi.org/10.1016/j.tripleo.2004.05.009
PMid:15660084

10. Minguez-Serra MP, Salort-Llorca C, Silvestre-Donat FJ. Chlorhexidine in the prevention of dry socket: effectiveness of different dosage forms and regimens. Med Oral Patol Oral Cir Bucal. 2009;14:e445-9.
PMid:19718007

11. Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, Magallanes-Abad N, Flores-Ruiz R, Basallote-Garcia M, et al. Randomized, double-blind study of effectiveness of intra-alveolar application of chlorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. J Oral Maxillofac Surg. 2010;68:1322-6.
http://dx.doi.org/10.1016/j.joms.2009.08.022
PMid:20346565

12. Balbuena L, Stambaugh KI, Ramirez SG, Yeager C. Effects of topical oral antiseptic rinses on bacterial counts of saliva in healthy human subjects. Otolaryngol Head Neck Surg. 1998;118:625-9.
PMid:9591860

13. Tomás I, Cousido MC, García-Caballero L, Rubido S, Limeres J, Diz P. Substantivity of a single chlorhexidine mouthwash on salivary flora: influence of intrinsic and extrinsic factors. J Dent. 2010;38:541-6.
http://dx.doi.org/10.1016/j.jdent.2010.03.012
PMid:20380865

14. Pietruska M, Paniczko A, Waszkiel D, Pietruski J, Bernaczyk A. Efficacy of local treatment with chlorhexidine gluconate drugs on the clinical status of periodontium in chronic periodontitis patients. Adv Med Sci. 2006;51:162-5.
PMid:17458083

15. Torres-Lagares D, Gutiérrez-Pérez JL, Infante-Cossío P, García-Calderón M, Romero-Ruiz MM, Serrera-Figallo MA. Randomized, double-blind study on effectiveness of intra-alveolar chlorhexidine gel in reducing the incidence of alveolar osteitis in mandibular third molar surgery. Int J Oral Maxillofac Surg. 2006;35:348-51.
http://dx.doi.org/10.1016/j.ijom.2005.08.002
PMid:16289676

16. Paolantonio M, Perinetti G, D'Ercole S, Graziani F, Catamo G, Sammartino G, et al. Internal Decontamination of Dental Implants: An In Vivo Randomized Microbiologic 6-Month Trial on the Effects of a Chlorhexidine Gel. J Periodontol. 2008;79:1419-25.
http://dx.doi.org/10.1902/jop.2008.070660
PMid:18672991

17. Slot DE, Rosema NAM, Hennequin-Hoenderdos NL, Versteeg PA, van der Velden U, van der Weijden GA. The effect of 1% chlorhexidine gel and 0.12% dentifrice gel on plaque accumulation: a 3-day non-brushing model. Int J Dent Hyg. 2010;8:294-300.
http://dx.doi.org/10.1111/j.1601-5037.2010.00487.x
PMid:20961386

18. Wallman C, Birkhed D. Effect of chlorhexidine varnish and gel on mutans streptococci in margins of restorations in adults. Caries Res. 2002;36:360-5.
http://dx.doi.org/10.1159/000065957

19. Hammad HM, Hammad MM, Abdelhadi IN, Khalifeh MS. Effects of topically applied agents on intra-oral wound healing in a rat model: a clinical and histomorphometric study. Int J Dent Hyg. 2011;9:9-16.
http://dx.doi.org/10.1111/j.1601-5037.2009.00410.x
PMid:21226845

20. Schulz KF, Altman DG, Moher D, Consort Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 2010;63:834-40.
http://dx.doi.org/10.1016/j.jclinepi.2010.02.005
PMid:20346629

21. Koerner KR. The removal of impacted third molars. Principles and procedures. Dent Clin North Am. 1994;38:255-78.
PMid:8206177

22. Savin J, Ogden GR. Third molar surgery--a preliminary report on aspects affecting quality of life in the early postoperative period. Br J Oral Maxillofac Surg. 1997;35:246-53.
http://dx.doi.org/10.1016/S0266-4356(97)90042-5

23. Colorado-Bonnin M, Valmaseda-Castellon E, Berini-Aytes L, Gay-Escoda C. Quality of life following lower third molar removal. Int J Oral Maxillofac Surg. 2006;35:343-7.
http://dx.doi.org/10.1016/j.ijom.2005.08.008
PMid:16280233

24. Alexander RE. Dental extraction wound management: a case against medicating postextraction sockets. J Oral Maxillofac Surg. 2000;58:538-51.
http://dx.doi.org/10.1016/S0278-2391(00)90017-X

25. Fardal O, Turnbull RS. A review of the literature on use of chlorhexidine in dentistry. J Am Dent Assoc. 1986;112:863-9.
PMid:2940282

26. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg. 2008;66:441-5.
http://dx.doi.org/10.1016/j.joms.2007.06.641
PMid:18280375

27. Ribeiro LG, Hashizume LN, Maltz M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: A systematic review of the literature. J Dent. 2007;35:359-70.
http://dx.doi.org/10.1016/j.jdent.2007.01.007
PMid:17391828

28. Paolantonio M, D'Ercole S, Pilloni A, D'Archivio D, Lisanti L, Graziani F, et al. Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gels in the treatment of periodontitis: a randomized multicenter trial. J Periodontol. 2009;80:1479-92.
http://dx.doi.org/10.1902/jop.2009.090050
PMid:19722799

29. Lee TH, Hu CC, Lee SS ,Chou MY, Chang YC. Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracelular glutathione levels. Int Endod J. 2010;43:430-35.
http://dx.doi.org/10.1111/j.1365-2591.2010.01700.x
PMid:20518937

30. Carrilho MR, Carvalho RM, Sousa EN, Nicolau J, Breschi L, Mazzoni A, et al. Substantivity of chlorhexidine to human dentin. Dent Mater. 2010;26:779-85.
http://dx.doi.org/10.1016/j.dental.2010.04.002
PMid:20472282 PMCid:2909541