Martn-Gonzlez J, Carmona-Fernndez A, Prez-Prez A, Snchez-Jimnez F, Snchez-Margalet V, Segura-Egea JJ. Expression and immunohistochemical localization of leptin in human periapical granulomas. Med Oral Patol Oral Cir Bucal. 2015 May 1;20 (3):e334-9.  

 

 

doi:10.4317/medoral.20385

http://dx.doi.org/doi:10.4317/medoral.20385

 

 

 

1. Segura-Egea JJ, Castellanos-Cosano L, Machuca-Portillo G, Lpez-Lpez J, Martn-Gonzlez J, Velasco-Ortega E, et al. Diabetes mellitus, periapical inflammation and endodontic treatment outcome. Med Oral Patol Oral Cir Bucal. 2012;17:e356-e61.
http://dx.doi.org/10.4317/medoral.17452

 

2. Mrton IJ, Kiss C. Characterization of inflammatory cell infiltrate in dental periapical lesions. Int Endod J. 1993;26:131-6.
http://dx.doi.org/10.1111/j.1365-2591.1993.tb00555.x

 

3. Mrton IJ, Kiss C. Overlapping protective and destructive regulatory pathways in apical periodontitis. J Endod. 2014;40:155-63.
http://dx.doi.org/10.1016/j.joen.2013.10.036

 

4. Langeland K, Block RM, Grossman LI. A histopathologic and histobacteriologic study of 35 periapical endodontic surgical specimens. J Endod. 1977;3:8-23.
http://dx.doi.org/10.1016/S0099-2399(77)80217-3

 

5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32.
http://dx.doi.org/10.1038/372425a0

 

6. Fantuzzi G, FaggioniIR. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000;68:437-46.

 

7. Snchez-Margalet V, Martn-Romero C, Santos-Alvarez J, Goberna R, Najib S, Gonzalez-Yanes C. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol. 2003;133:11-9.
http://dx.doi.org/10.1046/j.1365-2249.2003.02190.x

 

8. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, et al. Leptin regulates proinflammatory immune responses. FASEB J. 1998;12:57-65.

 

9. Matarese G. Leptin and the immune system: how nutritional status influences the immune response. Eur Cytokine Netw. 2000;11:7-14.

 

10. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83:1263-71.
http://dx.doi.org/10.1016/0092-8674(95)90151-5

 

11. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, et al. The full leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA. 1996;93:8374-8.
http://dx.doi.org/10.1073/pnas.93.16.8374

 

12. El Karim A, Linden GJ, Irwin CR, Lundy FT. Neuropeptides regulate expression of angiogenic growth factors in human dental pulp fibroblasts. J Endod. 2009;35:829-33.
http://dx.doi.org/10.1016/j.joen.2009.03.005

 

13. Martn-Gonzlez J, Snchez-Jimnez F, Prez-Prez A, Carmona-Fernndez A, Snchez-Margalet V, Segura-Egea JJ. Leptin expression in healthy and inflamed human dental pulp. Int Endod J. 2013;46:442-8.
http://dx.doi.org/10.1111/iej.12009

 

14. Martn-Gonzlez J, Prez-Prez A, Snchez-Jimnez F, Carmona-Fernndez A, Torres-Lagares D, Snchez-Margalet V, et al. Leptin receptor (LEPR) is up-regulated in inflamed human dental pulp. J Endod. 2013;39:1567-71.
http://dx.doi.org/10.1016/j.joen.2013.08.014

 

15. Johnson RB, Serio FG. Leptin within healthy and diseased human gingiva. J Periodontol. 2001;72:1254-7.
http://dx.doi.org/10.1902/jop.2000.72.9.1254

 

16. Bozkurt FY, Yetkin Ay Z, St R, Delibaş N, Demirel R . Gingival crevicular fluid leptin levels in periodontitis patients with long term and heavy smoking. J Periodontol. 2006;77:634-40.
http://dx.doi.org/10.1902/jop.2006.050277

 

17. Martinez ZR, Naruishi K, Yamashiro K, Myokai F, Yamada T, Matsuura K, et al. Gene profiles during root canal treatment in experimental rat periapical lesions. J Endod. 2007;33:936-43.
http://dx.doi.org/10.1016/j.joen.2007.04.016

 

18. Martn-Gonzlez J, Carmona-Fernndez A, Prez-Prez A, Snchez-Jimnez F, Snchez-Margalet V, Segura-Egea JJ. Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. Int Endod J. Epub ahead of print 2014.

 

19. Peixoto RF, Pereira JS, Nonaka CF, Silveira EJ, Miguel MC. Immunohistochemical analysis of FoxP3+ cells in periapical granulomas and radicular cysts. Arch Oral Biol. 2012;57:1159-64.
http://dx.doi.org/10.1016/j.archoralbio.2012.02.005

 

20. Taga T, Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol. 1997;15:797-819.
http://dx.doi.org/10.1146/annurev.immunol.15.1.797

 

21. Snchez-Margalet V, Martn-Romero C, Gonzlez-Yanes C, Goberna R, Rodrguez-Ba-o J, Muniain MA. Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Clin Exp Immunol. 2002;129:119-24.
http://dx.doi.org/10.1046/j.1365-2249.2002.01900.x

 

22. Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S. Leptin enhances CC-chemokine ligand expression in cultured murine macrophage. Biochem Biophys Res Commun. 2009;384:311-5.
http://dx.doi.org/10.1016/j.bbrc.2009.04.121

 

23. Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol. 2000;199:15-24.
http://dx.doi.org/10.1006/cimm.1999.1594

 

24. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006;176:7745-52.
http://dx.doi.org/10.4049/jimmunol.176.12.7745

 

25. Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, et al. High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol. 2001;167:4593-9.
http://dx.doi.org/10.4049/jimmunol.167.8.4593

 

26. Sun Z, Dragon S, Becker A, Gounni AS. Leptin Inhibits Neutrophil Apoptosis in Children via ERK/NF-kB-Dependent Pathways. PLoS ONE. 2013;8:e55249.
http://dx.doi.org/10.1371/journal.pone.0055249

 

27. Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med. 2001;33:95-102.
http://dx.doi.org/10.1038/emm.2001.17

 

28. Turner RT, Kalra SP, Wong CP, Philbrick KA, Lindenmaier LB, Boghossian S, et al. Peripheral leptin regulates bone formation. J Bone Miner Res. 2013;28:22-34.
http://dx.doi.org/10.1002/jbmr.1734

 

29. Shimada Y, Komatsu Y, Ikezawa-Suzuki I, Tai H, Sugita N, Yoshie H. The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. J Periodontol. 2010;81:1118-23.
http://dx.doi.org/10.1902/jop.2010.090741

 

30. Altay U, Grgan CA, Ağbaht K. Changes in inflammatory and metabolic parameters after periodontal treatment in patients with and without obesity. J Periodontol. 2013;84:13-23.
http://dx.doi.org/10.1902/jop.2012.110646