Fawzy El-Sayed K, Graetz C, Köhnlein T, Mekhemar M, Dörfer C. Effect of total sonicated Aggregatibacter actinomycetemcomitans fragments on gingival stem/progenitor cells. Med Oral Patol Oral Cir Bucal. 2018 Sep 1;23 (5):e569-78. 

 

 

doi:10.4317/medoral.22661

http://dx.doi.org/doi:10.4317/medoral.22661

 

 

1. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000. 1997;14:216-48.
https://doi.org/10.1111/j.1600-0757.1997.tb00199.x
PMid:9567973

 

2. Armitage GC. Development of a classification system for periodontal diseasesand conditions. Northwest Dent. 2000;79:31-5.
PMid:11413609

 

3. Albandar JM, Tinoco EMB. Global epidemiology of periodontal diseases in children and young persons. Periodontol 2000. 2002;29:153-76.
https://doi.org/10.1034/j.1600-0757.2002.290108.x

 

4. Diehl SR, Wu T, Michalowicz BS, Brooks CN, Califano JV, Burmeister JA, et al. Quantitative measures of aggressive periodontitis show substantial heritability and consistency with traditional diagnoses. J Periodontol. 2005;76:279-88.
https://doi.org/10.1902/jop.2005.76.2.279
PMid:15974854

 

5. Albandar JM. Aggressive and acute periodontal diseases. Periodontol 2000. 2014;65:7-12.
https://doi.org/10.1111/prd.12013
PMid:24738583

 

6. Kononen, E. and H.P. Muller, Microbiology of aggressive periodontitis. Periodontol 2000, 2014. 65(1): p. 46-78.
https://doi.org/10.1111/prd.12016
PMid:24738586

 

7. Kittichotirat W, Bumgarner RE, Asikainen S, Chen C. Identification of the pangenome and its components in 14 distinct Aggregatibacter actinomycetemcomitans strains by comparative genomic analysis. PLoS One. 2011;6:e22420.
https://doi.org/10.1371/journal.pone.0022420
PMid:21811606 PMCid:PMC3139650

 

8. Henderson B, Ward JM, Ready D. Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* periodontopathogen? Periodontol 2000. 2010;54:78-105.
https://doi.org/10.1111/j.1600-0757.2009.00331.x
PMid:20712635

 

9. Hoglund Aberg, C., et al., Cytolethal distending toxin in isolates of Aggregatibacter actinomycetemcomitans from Ghanaian adolescents and association with serotype and disease progression. Plos One, 2013. 8(6): p. e65781.
https://doi.org/10.1371/journal.pone.0065781
PMid:23922633 PMCid:PMC3683020

 

10. Blix IJ, Hars R, Preus HR, Helgeland K. Entrance of Actinobacillus actinomycetemcomitans into HEp-2 cells in vitro. J Periodontol. 1992;63:723-8.
https://doi.org/10.1902/jop.1992.63.9.723
PMid:1474473

 

11. Meyer DH, Lippmann JE, Fives Taylor PM. Invasion of epithelial cells by Actinobacillus actinomycetemcomitans: A dynamic, multistep process. Infection and Immunity. 1996;64:2988-97.
PMid:8757825 PMCid:PMC174179

 

12. Henderson B, Nair SP, Ward JM, Wilson M. Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans. Annu Rev Microbiol. 2003;57:29-55.
https://doi.org/10.1146/annurev.micro.57.030502.090908
PMid:14527274

 

13. Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000. 2001;25:77-88.
https://doi.org/10.1034/j.1600-0757.2001.22250106.x
PMid:11155183

 

14. Sgolastra F, Petrucci A, Gatto R, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis. J Periodontol. 2012;83:731-43.
https://doi.org/10.1902/jop.2012.110625
https://doi.org/10.1902/jop.2011.110432
PMid:22050545

 

15. Khosravi M, Bahrami ZS, Atabaki MS, Shokrgozar MA, Shokri F. Comparative effectiveness of hand and ultrasonic instrumentations in root surface planing in vitro. J Clin Periodontol. 2004;31:160-5.
https://doi.org/10.1111/j.0303-6979.2004.00458.x
PMid:15016018

 

16. Tunkel J, Heinecke A, Flemmig TF. A systematic review of efficacy of machine-driven and manual subgingival debridement in the treatment of chronic periodontitis. J Clin Periodontol. 2002;29:72-81;discussion 90-1.
https://doi.org/10.1034/j.1600-051X.29.s3.4.x
PMid:12787208

 

17. Drisko CL. Scaling and root planing without overinstrumentation: hand versus power-driven scalers. Curr Opin Periodontol. 1993:78-88.
PMid:8401851

 

18. Hägi TT, Hofmänner P, Salvi GE, Ramseier CA, Sculean A. Clinical outcomes following subgingival application of a novel erythritol powder by means of air polishing in supportive periodontal therapy: a randomized, controlled clinical study. Quintessence Int. 2013;44:753-61.
PMid:24078975

 

19. Pitt WG, Ross SA. Ultrasound increases the rate of bacterial cell growth. Biotechnol Prog. 2003;19:1038-44.
https://doi.org/10.1021/bp0340685
PMid:12790676 PMCid:PMC1361254

 

20. El-Sayed KM, Paris S, Graetz C, Kassem N, Mekhemar M, Ungefroren H, et al. Isolation and characterisation of human gingival margin-derived STRO-1/MACS(+) and MACS(-) cell populations. Int J Oral Sci. 2015;7:80-8.
https://doi.org/10.1038/ijos.2014.41
PMid:25257881 PMCid:PMC4817556

 

21. Fawzy-El-Sayed K, Mekhemar M, Adam-Klages S, Kabelitz D, Dörfer C. TlR expression profile of human gingival margin-derived stem progenitor cells. Med Oral Patol Oral Cir Bucal. 2016;21:e30-8.
https://doi.org/10.4317/medoral.20593
PMid:26615501 PMCid:PMC4765758

 

22. Li J, Jones B, Zhang Y, Vinardell T, Pei M. Low-density expansion protects human synovium-derived stem cells from replicative senescence: a preliminary study. Drug Deliv Transl Res. 2012;2:363-74.
https://doi.org/10.1007/s13346-012-0094-y
PMid:25787175

 

23. Ge S, Mrozik KM, Menicanin D, Gronthos S, Bartold PM. Isolation and characterization of mesenchymal stem cell-like cells from healthy and inflamed gingival tissue: potential use for clinical therapy. Regen Med. 2012;7:819-32.
https://doi.org/10.2217/rme.12.61
PMid:23164082

 

24. Kuznetsov SA, Krebsbach PH, Satomura K, Kerr J, Riminucci M, Benayahu D, et al. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res. 1997;12:1335-47
https://doi.org/10.1359/jbmr.1997.12.9.1335
PMid:9286749

 

25. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D,et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315-7.
https://doi.org/10.1080/14653240600855905
PMid:16923606

 

26. Mayer MP, Bueno LC, Hansen EJ, DiRienzo JM. Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans. Infect Immun. 1999;67:1227-37.
PMid:10024565 PMCid:PMC96451

 

27. Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010;140:771-6.
https://doi.org/10.1016/j.cell.2010.03.006
PMid:20303867

 

28. Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol. 2014;35:3-11.
https://doi.org/10.1016/j.it.2013.09.001
PMid:24269668 PMCid:PMC3947349

 

29. Nibali L, Farias BC, Vajgel A, Tu YK, Donos N. Tooth loss in aggressive periodontitis: a systematic review. J Dent Res. 2013;92:868-75.
https://doi.org/10.1177/0022034513501878
PMid:23955159

 

30. Christgau M, Männer T, Beuer S, Hiller KA, Schmalz G. Periodontal healing after non-surgical therapy with a modified sonic scaler: a controlled clinical trial. J Clin Periodontol. 2006;33:749-58.
https://doi.org/10.1111/j.1600-051X.2006.00981.x
PMid:16889629

 

31. Graetz C, Plaumann A, Wittich R, Springer C, Kahl M, Dörfer CE, et al. Removal of simulated biofilm: an evaluation of the effect on root surfaces roughness after scaling. Clin Oral Investig. 2017;21:1021-8.
https://doi.org/10.1007/s00784-016-1861-9
PMid:27233902

 

32. Fawzy El-Sayed KM, Mekhemar MK, Beck-Broichsitter BE, Bähr T, Hegab M, Receveur J, et al. Periodontal regeneration employing gingival margin-derived stem/progenitor cells in conjunction with IL-1ra-hydrogel synthetic extracellular matrix. J Clin Periodontol. 2015;42:448-57.
https://doi.org/10.1111/jcpe.12401
PMid:25875208

 

33. Fawzy El-Sayed KM, Paris S, Becker ST, Neuschl M, De Buhr W, Sälzer S, et al. Periodontal regeneration employing gingival margin-derived stem/progenitor cells: an animal study. J Clin Periodontol. 2012;39:861-70.
https://doi.org/10.1111/j.1600-051X.2012.01904.x
PMid:22694281

 

34. Su WR, Zhang QZ, Shi SH, Nguyen AL, Le AD. Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms. Stem Cells. 2011;29:1849-60.
https://doi.org/10.1002/stem.738
PMid:21987520

 

35. Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol. 2009;183:7787-98. Erratum in: J Immunol. 2010;184:1656.
https://doi.org/10.4049/jimmunol.0902318
PMid:19923445 PMCid:PMC2881945

 

36. Yang H, Gao LN, An Y, Hu CH, Jin F, Zhou J, et al. Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions. Biomaterials. 2013;34:7033-47.
https://doi.org/10.1016/j.biomaterials.2013.05.025
PMid:23768902

 

37. Fawzy El-Sayed KM, Dörfer CE. Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem. Stem Cells International. 2016;2016:7154327.
https://doi.org/10.1155/2016/7154327
PMid:27313628 PMCid:PMC4903147

 

38. El-Sayed KM, Paris S, Graetz C, Kassem N, Mekhemar M, Ungefroren H, et al. Isolation and characterisation of human gingival margin-derived STRO-1/MACS(+) and MACS(-) cell populations. Int J Oral Sci. 2015;7:80-8.
https://doi.org/10.1038/ijos.2014.41
PMid:25257881 PMCid:PMC4817556

 

39. Fine DH, Markowitz K, Furgang D, Velliyagounder K. Aggregatibacter actinomycetemcomitans as an early colonizer of oral tissues: epithelium as a reservoir? J Clin Microbiol. 2010;48:4464-73.
https://doi.org/10.1128/JCM.00964-10
PMid:20881174 PMCid:PMC3008435

 

40. Kang P, Korostoff J, Volgina A, Grzesik W, DiRienzo JM. Differential effect of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans on co-cultures of human oral cells. J Med Microbiol. 2005;54:785-94.
https://doi.org/10.1099/jmm.0.46077-0
PMid:16014433 PMCid:PMC1434796

 

41. Belibasakis GN, Johansson A, Wang Y, Chen C, Kalfas S, Lerner UH. The cytolethal distending toxin induces receptor activator of NF-kappaB ligand expression in human gingival fibroblasts and periodontal ligament cells. Infect Immun. 2005;73:342-51.
https://doi.org/10.1128/IAI.73.1.342-351.2005
PMid:15618171 PMCid:PMC538937

 

42. Lally ET, Hill RB, Kieba IR, Korostoff J. The interaction between RTX toxins and target cells. Trends Microbiol. 1999;7:356-61.
https://doi.org/10.1016/S0966-842X(99)01530-9

 

43. Kelk P, Johansson A, Claesson R, Hänström L, Kalfas S. Caspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun. 2003;71:4448-55.
https://doi.org/10.1128/IAI.71.8.4448-4455.2003
PMid:12874324 PMCid:PMC166001

 

44. Aberg CH, Kelk P, Johansson A. Aggregatibacter actinomycetemcomitans: Virulence of its leukotoxin and association with aggressive periodontitis. Virulence. 2015;6:188-95.
https://doi.org/10.4161/21505594.2014.982428
PMid:25494963 PMCid:PMC4601274

 

45. Sfakianakis A, Barr CE, Kreutzer D. Mechanisms of Actinobacillus actinomycetemcomitans-induced expression of interleukin-8 in gingival epithelial cells. J Periodontol. 2001;72:1413-9.
https://doi.org/10.1902/jop.2001.72.10.1413
PMid:11699484

 

46. Ochiai K, Kurita-Ochiai T. Role of T cell subset on the immunosuppression induced by Actinobacillus actinomycetemcomitans. J Oral Sci. 1999;41:105-10.
https://doi.org/10.2334/josnusd.41.105
PMid:10692834

 

47. Kurita-Ochiai T, Ochiai K, Ikeda T. Immunosuppressive effect induced by Actinobacillus actinomycetemcomitans: effect on immunoglobulin production and lymphokine synthesis. Oral Microbiol Immunol. 1992;7:338-43.
https://doi.org/10.1111/j.1399-302X.1992.tb00633.x
PMid:1299800

 

48. Salmasi S, Kalaskar DM, Yoon WW, Blunn GW, Seifalian AM. Role of nanotopography in the development of tissue engineered 3D organs and tissues using mesenchymal stem cells. World J Stem Cells. 2015;7:266-80.
https://doi.org/10.4252/wjsc.v7.i2.266
PMid:25815114 PMCid:PMC4369486

 

49. Kamen PR. Inhibition of keratinocyte proliferation by extracts of Actinobacillus actinomycetemcomitans. Infection and Immunity. 1983;42:1191-4.
PMid:6196295 PMCid:PMC264425

 

50. Shenker BJ, Kushner ME, Tsai CC. Inhibition of fibroblast proliferation by Actinobacillus actinomycetemcomitans. Infection and Immunity. 1982;38:986-92.
PMid:7152684 PMCid:PMC347847

 

51. Li C, Li G, Liu M, Zhou T, Zhou H. Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function. J Biosci Bioeng. 2016;121:213-9.
https://doi.org/10.1016/j.jbiosc.2015.05.017
PMid:26315505

 

52. Tang HN, Xia Y, Yu Y, Wu RX, Gao LN, Chen FM. Stem cells derived from "inflamed" and healthy periodontal ligament tissues and their sheet functionalities: a patient-matched comparison. J Clin Periodontol. 2016;43:72-84.
https://doi.org/10.1111/jcpe.12501
PMid:26719165

 

53. Lynch K, Pei M. Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies. Organogenesis. 2014;10:289-98.
https://doi.org/10.4161/15476278.2014.970089
PMid:25482504 PMCid:PMC4594597

 

54. Tung PS, Domenicucci C, Wasi S, Sodek J. Specific immunohistochemical localization of osteonectin and collagen types I and III in fetal and adult porcine dental tissues. J Histochem Cytochem. 1985;33:531-40.
https://doi.org/10.1177/33.6.3889139
PMid:3889139

 

55. Herbert BA, Novince CM, Kirkwood KL. Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. Molecular Oral Microbiology. 2016;31:207-27.
https://doi.org/10.1111/omi.12119
PMid:26197893 PMCid:PMC4723285

 

56. Murata T, Ansai T, Takehara T, Kobayashi S, Haneji T. Extracts of Prevotella intermedia and Actinobacillus actinomycetemcomitans inhibit alkaline phosphatase activity in osteoblastic cells in vitro. Oral Dis. 1997;3:106-12.
https://doi.org/10.1111/j.1601-0825.1997.tb00021.x
PMid:9467351