Mendes MLT, do Nascimento-Júnior EM, Reinheimer
DM, Martins-Filho PRS. Efficacy of proteolytic enzyme bromelain on
health outcomes after third molar surgery. Systematic review and
meta-analysis of randomized clinical trials. Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24
(1):e61-9.
doi:10.4317/medoral.22731
http://dx.doi.org/doi:10.4317/medoral.22731
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|
1. Rathnavelu V, Alitheen NB, Sohila S, Kanagesan S, Ramesh R. Potential role of bromelain in clinical and therapeutic applications. Biomed reports. 2016;5:283-8. |
|
|
|
|
|
2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. 1988;22:191-203. |
|
|
|
|
|
3. Dutta S, Bhattacharyya D. Enzymatic, antimicrobial and toxicity studies of the aqueous extract
of Ananas comosus (pineapple) crown leaf. J Ethnopharmacol.
2013;150:451-7. |
|
|
|
|
|
4. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell
Mol life Sci.
2001;58:1234-45. |
|
|
|
|
|
5. Castell JV,
Friedrich G, Kuhn CS, Poppe GE. Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma
after oral intake. Am J Physiol. 1997;273:G139-46. |
|
|
|
|
|
6. Shoham Y, Krieger Y, Tamir E, Silberstein E, Bogdanov-Berezovsky A, Haik J,
et al. Bromelain-based enzymatic
debridement of chronic wounds: A preliminary report. Int Wound
J. 2018;15:769-775. |
|
|
|
|
|
7. Schulz A, Fuchs PC, Rothermundt I, Hoffmann A, Rosenberg L, Shoham Y, et al. Enzymatic debridement of deeply burned faces: Healing and early scarring based on tissue preservation
compared to traditional surgical debridement. Burns. 2017;43:1233-43. |
|
|
|
|
|
8. Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier
JL, Balblanc JC. A complex
of three natural anti-inflammatory
agents provides relief of osteoarthritis pain. Altern Ther Health Med.
2014;20:32-7. |
|
|
|
|
|
9. Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces
mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine.
2002;9:681-6. |
|
|
|
|
|
10. Jayachandran S, Khobre P. Efficacy of Bromelain along with Trypsin,
Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the
treatment of TMJ Osteoarthritis
- A Randomised Clinical
Trial. J Clin diagnostic
Res. 2017;11:ZC09-ZC11. |
|
|
|
|
|
11. Majid OW, Al-Mashhadani BA. Perioperative bromelain reduces
pain and swelling and improves quality of life measures after mandibular third molar surgery: A randomized, double-blind, placebo-controlled
clinical trial. J Oral Maxillofac
Surg. 2014;72:1043-8. |
|
|
|
|
|
12. Tan Y, Li P.
Bromelain has significant
clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor. Oncol Lett. 2018;15:2962-6. |
|
|
|
|
|
13. de la
Barrera-Nunez M, Yanez-Vico
R, Batista-Cruzado A, Heurtebise-Saavedra J,
Castillo-de Oyague R, Torres-Lagares D. Prospective double-blind clinical trial evaluating the effectiveness of Bromelain in the third molar extraction postoperative period. Med Oral Patol Oral y Cir
Bucal. 2014;19:e157-62. |
|
|
|
|
|
14. de
Santana-Santos T, de Souza-Santos JAS, Martins-Filho
PRS, da Silva LCF, de Oliveira E Silva ED, Gomes ACA. Prediction
of postoperative facial swelling,
pain and trismus following third molar surgery based on preoperative variables. Med Oral Patol Oral Cir Bucal.
2013;18:e65-70. |
|
|
|
|
|
15. McGrath C, Comfort MB, Lo ECM, Luo Y. Changes in life quality following third molar surgery--the immediate postoperative period. Br Dent J. 2003;194:265-8;discussion 261. |
|
|
|
|
|
16. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic
reviews and meta-analyses:
the PRISMA statement. Int J Surg. 2010;8:336-41. |
|
|
|
|
|
17. Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing
risk of bias in randomised trials. BMJ.
2011;343:d5928. |
|
|
|
|
|
18. Cochran WG. The Combination of Estimates from Different Experiments. Biometrics.
1954;10:101. |
|
|
|
|
|
19. Higgins JPT, Deeks JJ, Altman DG. Chapter 16: Special topics in statistics. In: Higgins JPT,
Green S (editors), Cochrane Handbook
for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 [Internet]. |
|
|
|
|
|
20. Cochran WG. The Combination of Estimates from Different Experiments. Biometrics.
1954;10:101. |
|
|
|
|
|
21. Higgins JPT, Thompson SG. Quantifying
heterogeneity in a meta-analysis.
Stat Med.
2002;21:1539-58. |
|
|
|
|
|
22. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus
on rating quality of evidence and strength of recommendations. BMJ. 2008 Apr
26;336:924-6. |
|
|
|
|
|
23. Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ. What is "quality of evidence" and why is it
important to clinicians? BMJ. 2008;336:995-8. |
|
|
|
|
|
24. Ghensi P, Cucchi A, Creminelli L, Tomasi C, Zavan B, Maiorana C. Effect of Oral Administration
of Bromelain on Postoperative Discomfort after Third Molar Surgery. J Craniofac Surg. 2017;28:e191-7. |
|
|
|
|
|
25. Bormann KH, Weber K, Kloppenburg
H, Koch A, Meiser P, Gellrich
NC. Perioperative Bromelain
Therapy after Wisdom Teeth Extraction – A Randomized,
Placebo-Controlled, Double-Blinded,
Three-Armed, Cross-Over Dose-Finding Study. Phyther Res. 2016;30:2012-9. |
|
|
|
|
|
26. Ordesi P, Pisoni L, Nannei P, Macchi M, Borloni R,
Siervo S. Therapeutic efficacy
of bromelain in impacted third molar surgery: a randomized controlled clinical study. Quintessence Int (Berl). 2014;45:679-84. |
|
|
|
|
|
27. Au AHY, Choi SW, Cheung CW, Leung YY. The Efficacy and Clinical Safety of
Various Analgesic Combinations for Post-Operative Pain after Third Molar Surgery: A Systematic Review and Meta-Analysis. Staffieri F, editor. PLoS One. 2015;10:e0127611. |
|
|
|
|
|
28. Ong CKS, Lirk P, Tan CH,
Seymour RA. An Evidence-Based
Update on Nonsteroidal Anti-Inflammatory Drugs. Clin Med
Res [Internet]. 2007;5:19-34. |
|
|
|
|
|
29. Canellas JV dos S, Ritto FG, Medeiros PJD. Evaluation of postoperative complications after mandibular third molar surgery with the use of platelet-rich fibrin: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2017;46:1138-46. |
|
|
|
|
|
30. Landucci A, Wosny AC, Uetanabaro LC, Moro A, Araujo MR. Efficacy
of a single dose of low-level
laser therapy in reducing
pain, swelling, and trismus following third molar extraction surgery. Int J Oral Maxillofac Surg. 2016;45:392-8. |
|
|
|
|
|
31. Gaspani L, Limiroli E, Ferrario P, Bianchi M. In vivo and in vitro Effects of Bromelain on PGE2 and SP Concentrations
in the Inflammatory Exudate in Rats. Pharmacology. 2002;65:83-6. |
|
|
|
|
|
32. Kumakura S, Yamashita M, Tsurufuji S. Effect of bromelain on kaolin-induced inflammation in rats. Eur J Pharmacol.
1988;150:295-301. |
|
|
|
|
|
33. Lotz-Winter H. On the pharmacology of bromelain: an update with special
regard to animal studies on dose-dependent
effects. Planta Med.
1990;56:249-53. |
|
|
|
|
|
34. Hale LP, Greer PK, Trinh CT, James CL. Proteinase activity and stability of natural bromelain preparations. Int Immunopharmacol. 2005;5:783-93. |
|
|
|
|
|
35. de Lencastre Novaes LC, Jozala AF, Lopes AM, de
Carvalho Santos-Ebinuma V, Mazzola
PG, Pessoa Junior A. Stability, purification,
and applications of bromelain:
A review. Biotechnol Prog. 2016;32:5-13. |
|