López-Quiles J, Forteza-López A, Montiel M, Clemente C, Fernández-Tresguerres JA, Fernández-Tresguerres I. Effects of locally applied Insulin-like Growth Factor-I on osseointegration. Med Oral Patol Oral Cir Bucal. 2019 Sep 1;24 (5):e652-8.   

 

doi:10.4317/medoral.22973

http://dx.doi.org/doi:10.4317/medoral.22973

_________________________________________________________________________________________________________________________________

 

References

1. Fernández-Tresguerres Hernández-Gil IF, Alobera Gracia MA, del Canto Pingarrón M, Blanco Jerez L. Physiological bases of bone regeneration I. Histology and physiology of bone tissue. Med Oral Patol Oral Cir Bucal. 2006;11:47-51.

 

2. Giustina A, Mazziotti G, Canalis E. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev. 2008;29:535-559.
https://doi.org/10.1210/er.2007-0036
PMid:18436706 PMCid:PMC2726838

 

3. Gazzerro E, Canalis E. Skeletal actions of insulin-like growth factors. Expert Rev Endocrinol Metab. 2006;1:47-56.
https://doi.org/10.1586/17446651.1.1.47
PMid:30743768

 

4. McCarthy TL, Centrella M, Canalis E. Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone. Endocrinology. 1989;124:1247-1253.
https://doi.org/10.1210/endo-124-3-1247
PMid:2645113

 

5. Canalis E, McCarthy TL, Centrella M. Growth factors and the skeletal system. J Endocrinol Invest. 1989;12:577-584.
https://doi.org/10.1007/BF03350764
PMid:2687354

 

6. Misra M, Klibanski A. Anorexia nervosa and osteoporosis. Rev Endocr Metab Disord. 2006;7:91-99.
https://doi.org/10.1007/s11154-006-9005-1
PMid:16972186

 

7. Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A. Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab. 1996;81:3864-3870.
https://doi.org/10.1210/jcem.81.11.8923830
PMid:8923830

 

8. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis: prevention, diagnosis and treatment. JAMA. 2001;285:785-795.
https://doi.org/10.1001/jama.285.6.785
PMid:11176917

 

9. Canalis E. Management of endocrine disease: Novel anabolic treatments for osteoporosis. Eur J Endocrinol. 2018;178:R33-R44.
https://doi.org/10.1530/EJE-17-0920
PMid:29113980 PMCid:PMC5819362

 

10. Merheb J, Temmerman A, Rasmusson L, Kübler A, Thör A, Quirynen M. Influence of skeletal and local bone density on dental implant stability in patients with osteoporosis. Clin Impl Dent Rel Res. 2016;18:253-260.
https://doi.org/10.1111/cid.12290
PMid:26864614

 

11. Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, et al. Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization. J Biol Chem. 2002;277:44005-12.
https://doi.org/10.1074/jbc.M208265200
PMid:12215457

 

12. Zhao G, Monier-Faugere MC, Langub MC, Geng Z, Nakayama T, Pike JW, Chernausek SD, Rosen CJ, Donahue LR, Malluche HH, Fagin JA, Clemens TL. Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation. Endocrinology. 2000;141:2674-82.
https://doi.org/10.1210/endo.141.7.7585
PMid:10875273

 

13. Cemborain A, Castilla Cortázar I, García M, Muguerza B, Delgado G, Díaz Sánchez M, et al. Effects of IGF-I treatment on osteopenia in rats with advanced liver cirrosis. Journal of Physiology and Biochemistry. 2000;56:91E9.
https://doi.org/10.1007/BF03179904
PMid:11014614

 

14. Locatelli V, Bianchi VE. Effect of GH/IGF-1 on Bone Metabolism and Osteoporosis. Int J Endocrinol. 2014;2014:235060.
https://doi.org/10.1155/2014/235060
PMid:25147565 PMCid:PMC4132406

 

15. Sugimoto T, Nishiyama K, Kuribayashi F, Chiara K. Serum Levels of Insulin-like Growth Factor (IGF) I, IGF-Binding Protein (IGFBP)-2, and IGFBP-3 in Osteoporotic Patients with and without Spinal Fractures. J Bone Miner Res. 1997;12:1272-1279.
https://doi.org/10.1359/jbmr.1997.12.8.1272
PMid:9258758

 

16. Garnero P, Sornay-Rendu E, Delmas PD. Low serum IGF-I and occurrence of osteoporotic fractures in postmenopausal women. The Lancet. 2000;355:898-899.
https://doi.org/10.1016/S0140-6736(99)05463-X

 

17. Langlois JA, Rosen CJ, Visser M, Hannan MT, Harris T, Wilson PW, Kiel DP. Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study. J Clin Endocrinol Metab. 1998;83:4257-4262.
https://doi.org/10.1210/jc.83.12.4257
PMid:9851760

 

18. Backeljauw PF, Underwood LE. Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome. A clinical research center study. GHIS Collaborative Group. J Clin Endocrinol Metab. 1996;81:3312-3317.
https://doi.org/10.1210/jcem.81.9.8784089
PMid:8784089

 

19. Carel JC, Chaussain JL, Chatelain P, Savage MO. Growth hormone insensitivity syndrome (Laron syndrome): main characteristics and effects of IGF-1 treatment. Diabetes Metab. 1996;22:251-256.

 

20. Savage MO, Dunger DB. Recombinant IGF-I therapy in insulin-dependent diabetes mellitus. Diabetes Metab. 1996;22:257-260.

 

21. Harvey S, Hull KL. Growth hormone. A paracrine growth factor? Endocrine. 1997;7:267-279.
https://doi.org/10.1007/BF02801319
PMid:9657062

 

22. Tresguerres IF, Clemente C, Donado M, Gómez-Pellico L, Blanco L, Alobera MA, Tresguerres AF. Local administration of growth hormone enhances periimplant bone reaction in an osteoporotic rabbit model: An histologic, histomorphometric and densitometric study. Clin Oral Impl Res. 2002;13:631-636.
https://doi.org/10.1034/j.1600-0501.2002.130609.x

 

23. Martin Monge E, Tresguerres IF, Clemente C, Tresguerres AF. Local application of growth hormone to enhance osseointegration in osteoporotic bones: a morphometric and densitometric study. Int J Oral Maxillofac. Implants 2017;32:751-758.
https://doi.org/10.11607/jomi.5320
PMid:28708907

 

24. Ke HZ, Richards WG, Li X, Ominsky MS. Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocr Rev. 2012;33:747-783.
https://doi.org/10.1210/er.2011-1060
PMid:22723594

 

25. McClung MR, Grauer A, Boonen S, Bolognese MA, Brown JP, Diez-Perez A, et al. Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med. 2014;370:412-420.
https://doi.org/10.1056/NEJMoa1305224
PMid:24382002

 

26. Anastasilakis AD, Toulis KA, Goulis DG, et al. Efficacy and safety of denosumab in postmenopausal women with osteopenia or osteoporosis: A systematic review and a meta-analysis. Horm Metab Res 2009;41:721-729.
https://doi.org/10.1055/s-0029-1224109
PMid:19536731

 

27. Lindsay RC, Mohan S. Skeletal Effects of Growth Hormone and Insulin-like Growth Factor-I Therapy. Mol Cell Endocrinol. 2016;5:44-55.
https://doi.org/10.1016/j.mce.2015.09.017
PMid:26408965 PMCid:PMC4808510

 

28. Martin Monge E, Tresguerres IF, Blanco L, Khraisat A, Rodriguez-Torres R, Tresguerres JAF. Validation of an Osteoporotic Animal Model for Dental Implant Analyses: An In Vivo Densitometric Study in Rabbits. Int J Oral Maxillofac Implants. 2011;26:725-730.

 

29. Lugero GG, Falco Caparbo V de, Guzzo ML, Konig B Jr, Jorgetti V. Histomorphometric evaluation of titanium in osteoporotic rabbits. Implant Dent. 2000;9:303-309.
https://doi.org/10.1097/00008505-200009040-00005
PMid:11307552

 

30. Duarte PM, Cesar Neto JB, Gonçalves PF, Sallum EA, Nociti FH. Estrogen deficiency affects bone healing around titanium implants: a histometric study in rats. Implant Dent. 2003;12:340-6.
https://doi.org/10.1097/01.ID.0000099750.26582.4B
PMid:14752971

 

31. De Melo L, Piattelli A, Lezzi G, D'Avila S, Zenóbio EG, Shibli JA. Human histologic evaluation of a six-year-old threaded implant retrieved from a subject with osteoporosis. J Contemp Dent Pract. 2008;9:99-105.
https://doi.org/10.5005/jcdp-9-3-99
PMid:18335125

 

32. Shibli JA, Grande PA, D'Avila S, Iezzi G, Piattelli A. Evaluation of human bone around a dental implant retrieved from a subject with osteoporosis. Gen Dent. 2008;56:64-7.

 

33. Rosen CJ, Dimai HP, Vereault D, Donahue LR, Beamer WG, Farley J, et al. Circulating and Skeletal Insulin-like Growth Factor I (IGF-I) Concentrations in two inbred Strains of Mice with Different Bone Mineral Densities. Bone. 1997;21:217-23.
https://doi.org/10.1016/S8756-3282(97)00143-9

 

34. Grinspoon S, Thomas L, Miller K, Herzog D, Klibanski A. Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab. 2002;87:2883-91.
https://doi.org/10.1210/jcem.87.6.8574
PMid:12050268

 

35. Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res. 2006;21:1350-1358.
https://doi.org/10.1359/jbmr.060610
PMid:16939393

 

36. Lynch SE, Buser D, Hernandez RA, Weber HP, Stich H, Fox CH, et al. Effects of the Platelet-Derived Growth Factor/Insulin-like Growth Factor-I Combination on Bone Regeneration Around Titanium Dental Implants. Results of a Pilot Study in Beagle Dogs. J Periodontol. 1991;62:710-6.
https://doi.org/10.1902/jop.1991.62.11.710
PMid:1753324

 

37. Stefani CM, Machado MA, Sallum EA, Salum AW, Toledo S, Nociti H Jr. PlateletEderived growth factor/insuline like growth factor-1 combination and bone regeneration around implants placed into extraction sockets: a histometric study in dogs. Implant Dent. 2000;9:126.
https://doi.org/10.1097/00008505-200009020-00004
PMid:11314699

 

38. Nociti Junior FH, Stefani CM, Machado MA, Sallum EA, Toledo S, Sallum AW. Histometric evaluation of bone regeneration around immediate implants partially in contact with bone: a pilot study in dogs. Implant Dent. 2000;9:321-8.
https://doi.org/10.1097/00008505-200009040-00007
PMid:11307554

 

39. Xing H, Wang X, Xiao S, Zhang G, Li M, Wang P, et al. Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF-1 and coated on titanium implant under osteoporotic condition. Int J Nanomedicine 2017;12:7709-7720.
https://doi.org/10.2147/IJN.S148001
PMid:29089765 PMCid:PMC5656347

 

40. Tresguerres IF, Blanco L, Clemente C, Tresguerres JA. Effects of local administration of growth hormone in peri-implant bone: an experimental study with implants in rabbit tibiae. Int J Oral Maxillofac Implants. 2003;18:807-811.

 

41. Tresguerres IF, Alobera MA, Baca R, Tresguerres JA. Histologic, morphometric, and densitometric study of peri-implant bone in rabbits with local administration of growth hormone. Int J Oral Maxillofac Implants. 2005;20:193-202.

 

42. Fowlkes JL, Thrailkill KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, et al. Effects of Systemic and Local Administration of Recombinant Human IGF-I (rhIGF-I) on De Novo Bone Formation in an Aged Mouse Model. J Bone Miner Res. 2006;21:1359-1366.
https://doi.org/10.1359/jbmr.060618
PMid:16939394 PMCid:PMC2424402

 

43. Abbaspour A, Takata S, Matsui Y, Katoh S, Takahashi M, Yasui N. Continuous infusion of insulin-like growth factor-I into the epiphysis of the tibia. International Orthopaedics. 2008;32:395-402
https://doi.org/10.1007/s00264-007-0336-7
PMid:17431620 PMCid:PMC2323423