López-Martínez J, Chueca N, Padial-Molina M, Fernandez-Caballero JA, García F, O’Valle, et al. Bacteria associated with periodontal disease are also increased in health. Med Oral Patol Oral Cir Bucal. 2020 Nov 1;25 (6):e745-51.


doi:10.4317/medoral.23766

https://dx.doi.org/doi:10.4317/medoral.23766


1. Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010;8:481-90.

https://doi.org/10.1038/nrmicro2337

PMid:20514045 

2. Hajishengallis G. The inflammophilic character of the periodontitis-associated microbiota. Mol Oral Microbiol. 2014;29:248-57.

https://doi.org/10.1111/omi.12065

PMid:24976068 PMCid:PMC4232466

3. Sanz M, Lau L, Herrera D, Morillo JM, Silva A. Methods of detection of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythensis in periodontal microbiology, with special emphasis on advanced molecular techniques: a review. J Clin Periodontol. 2004;31:1034-47.

https://doi.org/10.1111/j.1600-051X.2004.00609.x

PMid:15560803 

4. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25:134-44.

https://doi.org/10.1111/j.1600-051X.1998.tb02419.x

PMid:9495612 

5. Kumar PS. Oral microbiota and systemic disease. Anaerobe. 2013;24:90-3.

https://doi.org/10.1016/j.anaerobe.2013.09.010

PMid:24128801 

6. Kumar PS, Griffen AL, Moeschberger ML, Leys EJ. Identification of candidate periodontal pathogens and beneficial species by quantitative 16S clonal analysis. J Clin Microbiol. 2005;43:3944-55.

https://doi.org/10.1128/JCM.43.8.3944-3955.2005

PMid:16081935 PMCid:PMC1233920

7. Padial-Molina M, López-Martínez J, O'Valle F, Galindo-Moreno P. Microbial profiles and detection techniques in peri-implant diseases: a systematic review. J Oral Maxillofac Res. 2016;7:e10.

https://doi.org/10.5037/jomr.2016.7310

PMid:27833735 PMCid:PMC5100635

8. Tözüm TF, Dursun E, Galindo-Moreno P, Juodzbalys G, López-Martínez J, O'Valle F, et al. The 1st Baltic Osseointegration Academy and Lithuanian University of Health Sciences Consensus Conference 2016. Summary and Consensus Statements: Group II - Peri-Implantitis Diagnostics and Decision Tree. J Oral Maxillofac Res. 2016;7:e11.

https://doi.org/10.5037/jomr.2016.7311

PMid:27833736 PMCid:PMC5100636

9. Nagpal S, Haque MM, Mande SS. Vikodak - A Modular Framework for Inferring Functional Potential of Microbial Communities from 16S Metagenomic Datasets. PLoS One. 2016;11:e0148347.

https://doi.org/10.1371/journal.pone.0148347

PMid:26848568 PMCid:PMC4746064

10. The NIH HMP Working Group, Peterson J, Garges S, Giovanni M, McInnes P, Wang L, et al. The NIH Human Microbiome Project. Genome Res. 2009;19:2317-23.

https://doi.org/10.1101/gr.096651.109

PMid:19819907 PMCid:PMC2792171

11. Solbiati J, Frias-Lopez J. Metatranscriptome of the Oral Microbiome in Health and Disease. J Dent Res. 2018;97:492-500.

https://doi.org/10.1177/0022034518761644

PMid:29518346 PMCid:PMC5958373

12. Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ. Prevalence of Periodontitis in Adults in the United States: 2009 and 2010. J Dent Res. 2012;91:914-20.

https://doi.org/10.1177/0022034512457373

PMid:22935673 

13. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett C, Knight R, Gordon JI. The human microbiome project: exploring the microbial part of ourselves in a changing world. Nature. 2007;449:804-10.

https://doi.org/10.1038/nature06244

PMid:17943116 PMCid:PMC3709439

14. Wade WG. Has the use of molecular methods for the characterization of the human oral microbiome changed our understanding of the role of bacteria in the pathogenesis of periodontal disease?: Molecular ecology of periodontitis. J Clin Periodontol. 2011;38:7-16.

https://doi.org/10.1111/j.1600-051X.2010.01679.x

PMid:21323699 

15. Cross B, Faustoferri RC, Quivey RG. What Are We Learning and What Can We Learn from the Human Oral Microbiome Project? Curr Oral Heal Reports. 2016;3:56-63.

https://doi.org/10.1007/s40496-016-0080-4

PMid:27152251 PMCid:PMC4852878

16. Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, et al. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011;10:497-506.

https://doi.org/10.1016/j.chom.2011.10.006

PMid:22036469 PMCid:PMC3221781

17. Marsh PD. Are dental diseases examples of ecological catastrophes?. Microbiology. 2003;149:279-94.

https://doi.org/10.1099/mic.0.26082-0

PMid:12624191 

18. Duran-Pinedo AE, Paster B, Teles R, Frias-Lopez J. Correlation network analysis applied to complex biofilm communities. PLoS One. 2011;6:e28438.

https://doi.org/10.1371/journal.pone.0028438

PMid:22163302 PMCid:PMC3233593

19. Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27:409-19.

https://doi.org/10.1111/j.2041-1014.2012.00663.x

PMid:23134607 PMCid:PMC3653317

20. Griffen AL, Beall CJ, Campbell JH, Firestone ND, Kumar PS, Yang ZK, et al. Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing. ISME J. 2012;6:1176-85.

https://doi.org/10.1038/ismej.2011.191

PMid:22170420 PMCid:PMC3358035

21. Park OJ, Yi H, Jeon JH, Kang SS, Koo KT, Kum KY, et al. Pyrosequencing analysis of subgingival microbiota in distinct periodontal conditions. J Dent Res. 2015;94:921-7.

https://doi.org/10.1177/0022034515583531

PMid:25904141 

22. Moon J-H, Lee J-H, Lee J-Y. Subgingival microbiome in smokers and non-smokers in Korean chronic periodontitis patients. Mol Oral Microbiol. 2015;30:227-41.

https://doi.org/10.1111/omi.12086

PMid:25283067 

23. Aguiar-Pulido V, Huang W, Suarez-Ulloa V, Cickovski T, Mathee K, Narasimhan G. Metagenomics, Metatranscriptomics, and Metabolomics Approaches for Microbiome Analysis. Evol Bioinform Online. 2016;12:5-16.

https://doi.org/10.4137/EBO.S36436

PMid:27199545 PMCid:PMC4869604

24. Takahashi N. Oral Microbiome Metabolism: From "Who Are They?" to "What Are They Doing?". J Dent Res. 2015;94:1628-37.

https://doi.org/10.1177/0022034515606045

PMid:26377570 

25. Frias-Lopez J, Duran-Pinedo A. Effect of Periodontal Pathogens on the Metatranscriptome of a Healthy Multispecies Biofilm Model. J Bacteriol. 2012;194:2082-95.

https://doi.org/10.1128/JB.06328-11

PMid:22328675 PMCid:PMC3318478

26. Jorth P, Turner KH, Gumus P, Nizam N, Buduneli N, Whiteley M. Metatranscriptomics of the human oral microbiome during health and disease. MBio. 2014;5:e01012-01014.

https://doi.org/10.1128/mBio.01012-14

PMid:24692635 PMCid:PMC3977359

27. Szafrański SP, Deng Z-L, Tomasch J, Jarek M, Bhuju S, Meisinger C, et al. Functional biomarkers for chronic periodontitis and insights into the roles of Prevotella nigrescens and Fusobacterium nucleatum; a metatranscriptome analysis. NPJ biofilms microbiomes. 2015;1:15017.

https://doi.org/10.1038/npjbiofilms.2015.17

PMid:28721234 PMCid:PMC5515211

28. Dabdoub SM, Ganesan SM, Kumar PS. Comparative metagenomics reveals taxonomically idiosyncratic yet functionally congruent communities in periodontitis. Sci Rep. 2016;6:38993.

https://doi.org/10.1038/srep38993

PMid:27991530 PMCid:PMC5172196

29. Duran-Pinedo AE, Chen T, Teles R, Starr JR, Wang X, Krishnan K, et al. Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis. ISME J. 2014;8:1659-72.

https://doi.org/10.1038/ismej.2014.23

PMid:24599074 PMCid:PMC4817619

30. Langille MGI, Zaneveld J, Caporaso JG, McDonald D, Knights D, Reyes JA, et al. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol. 2013;31:814-21.

https://doi.org/10.1038/nbt.2676

PMid:23975157 PMCid:PMC3819121