1. Zhi X, Lamperska K, Golusinski P, Schork NJ, Luczewski L, Kolenda T, et al. Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence. Oncotarget. 2015;6:547-55.

https://doi.org/10.18632/oncotarget.2772

PMid:25575813 PMCid:PMC4381614

2. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45:309- 16.

https://doi.org/10.1016/j.oraloncology.2008.06.002

PMid:18804401 

3. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.

https://doi.org/10.3322/caac.20107

PMid:21296855 

4. Bello IO, Vered M, Dayan D, Dobriyan A, Yahalom R, Alanen K. Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer. Oral Oncol. 2011;47:33-8.

https://doi.org/10.1016/j.oraloncology.2010.10.013

PMid:21112238 

5. Reid PA, Wilson P, Li Y, Marcu LG, Bezak E. Current understanding of cancer stem cells: Review of their radiobiology and role in head and neck cancers. Head Neck. 2017;39:1920-32.

https://doi.org/10.1002/hed.24848

PMid:28644558 

6. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871-90.

https://doi.org/10.1016/j.cell.2009.11.007

PMid:19945376 

7. Zhang Z, Dong Z, Lauxen IS, Filho MS, Nör JE. Endothelial Cell-Secreted EGF Induces Epithelial to Mesenchymal Transition and Endows Head and Neck Cancer Cells with Stem-like Phenotype. Cancer Res. 2014;74:2869-81.

https://doi.org/10.1158/0008-5472.CAN-13-2032

PMid:24686166 PMCid:PMC4028029

8. Thierauf J, Veit JA, Hess J. Epithelial-to-Mesenchymal transition in the pathogenesis and therapy of head and neck cancer. Cancers (Basel). 2017;9:E76.

https://doi.org/10.3390/cancers9070076

PMid:28671620 PMCid:PMC5532612

9. Książkiewicz M, Markiewicz A, Zaczek AJ. Epithelial-mesenchymal transition: a hallmark in metastasis formation linking circulating tumor cells and cancer stem cells. Pathobiology. 2012;79:195-208.

https://doi.org/10.1159/000337106

PMid:22488297 

10. Tsai MS, Chen WC, Lai CH, Chen YY, Chen MF. Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer. Oral Oncol. 2017;73:88-96.

https://doi.org/10.1016/j.oraloncology.2017.08.007

PMid:28939082 

11. Hildebrand LC, Carvalho AL, Lauxen IS, Nör JE, Cerski CTS, Sant'Ana Filho M. Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas. J Oral Pathol Med. 2014;43:499-506.

https://doi.org/10.1111/jop.12169

PMid:24527751 

12. Sung WJ, Park KS, Kwak SG, Hyun DS, Jang JS, Park KK. Epithelial-mesenchymal transition in patients of pulmonary adenocarcinoma: correlation with cancer stem cell markers and prognosis. Int J Clin Exp Pathol. 2015;8:8997-9009.

PMid:26464642

13. Koh YW, Han JH, Haam S, Jung J. ALDH1 expression correlates with an epithelial-like phenotype and favorable prognosis in lung adenocarcinoma: a study based on immunohistochemistry and mRNA expression data. J Cancer Res Clin Oncol. 2019;145:1427-36.

https://doi.org/10.1007/s00432-019-02906-2

PMid:30923946 

14. Wu CC, Xiao Y, Li H, Mao L, Deng WW, Yu GT, et al. Overexpression of FAM3C is associated with poor prognosis in oral squamous cell carcinoma. Pathol Res Pract. 2019;215:772-8.

https://doi.org/10.1016/j.prp.2019.01.019

PMid:30683473 

15. Noguti J, De Moura CF, De Jesus GP, Da Silva VH, Hossaka TA, Oshima CT, et al. Metastasis from oral cancer: an overview. Cancer Genomics Proteomics. 2012;9:329-35.

PMid:22990112

16. Zhang Z, Filho MS, Nör JE. The biology of head and neck cancer stem cells. Oral Oncol. 2012;48:1- 9.

https://doi.org/10.1016/j.oraloncology.2011.10.004

PMid:22070916 PMCid:PMC3261238

17. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992;166:375-81.

https://doi.org/10.1002/path.1711660409

PMid:1517891 

18. Nieto MA, Huang RY, Jackson RA, Thiery JP. EMT: 2016. Cell. 2016;166:21-45.

https://doi.org/10.1016/j.cell.2016.06.028

PMid:27368099 

19. Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet. 2008;371:1695-709.

https://doi.org/10.1016/S0140-6736(08)60728-X

PMid:18486742

20. Durazzo MD, de Araujo CE, Brandão Neto JS, Potenza Ade S, Costa P, Takeda F, et al. Clinical and epidemiological features of oral cancer in a medical school teaching hospital from 1994 to 2002: increasing incidence in women, predominance of advanced local disease, and low incidence of neck metastases. Clinics (São Paulo). 2005;60:293-8.

https://doi.org/10.1590/S1807-59322005000400006

PMid:16138235 

21. Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer. 2011;11:9-22.

https://doi.org/10.1038/nrc2982

PMid:21160525 

22. Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, et al. Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res. 2011;71:5317-26.

https://doi.org/10.1158/0008-5472.CAN-11-1059

PMid:21685475 

23. Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Kobayashi J, Sasaki T, et al. High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis. Pathol Int. 2012;62:684-9.

https://doi.org/10.1111/j.1440-1827.2012.02851.x

PMid:23005595 

24. Qian X, Wagner S, Ma C, Coordes A, Gekeler J, Klussmann JP, et al. Prognostic significance of ALDH1A1 positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma. J Cancer Res Clin Oncol. 2014;140:1151-8.

https://doi.org/10.1007/s00432-014-1685-4

PMid:24770634 

25. Leinung M, Ernst B, Döring C, Wagenblast J, Tahtali A, Diensthuber M, et al. Expression of ALDH1A1 and CD44 in primary head and neck squamous cell carcinoma and their value for carcinogenesis, tumor progression and cancer stem cell identification. Oncol Lett. 2015;10:2289-94.

https://doi.org/10.3892/ol.2015.3542

PMid:26622836 PMCid:PMC4579825

26. Tamatani T, Takamaru N, Ohe G, Akita K, Nakagawa T, Miyamoto Y. Expression of CD44, CD44v9, ABCG2, CD24, Bmi-1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors. Oncol Lett. 2018;16:1133-40.

https://doi.org/10.3892/ol.2018.8703

PMid:29963189 PMCid:PMC6019923

27. Zhou C, Sun B. The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis. Oral Oncol. 2014;50:1144-8.

https://doi.org/10.1016/j.oraloncology.2014.08.018

PMid:25264224 

28. Marangon Junior H, Melo VVM, Caixeta ÂB, Souto GR, Souza PEA, de Aguiar MCF, et al. Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma. Head Neck Pathol. 2019;13:535-42.

https://doi.org/10.1007/s12105-018-0985-4

PMid:30430416 PMCid:PMC6854139

29. Tan DS, Potts HW, Leong AC, et al. The biological and prognostic significance of cell polarity and E-cadherin in grade I infiltrating ductal carcinoma of the breast. J Pathol. 1999;189:20-7.

https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<20::AID-PATH394>3.0.CO;2-2

PMid:10451483

30. Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer. 2005;5:744-9.

https://doi.org/10.1038/nrc1694

PMid:16148886