Martins-de-Barros AV, Barros AMI, Siqueira AKCd, Lucena EEdS, Sette de Souza PH, Araújo FAdC. Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2021 Mar 1;26 (2):e141-50.


doi:10.4317/medoral.24088

https://dx.doi.org/doi:10.4317/medoral.24088


1. Colorado-Bonnin M, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C. Quality of life following lower third molar removal. Int J Oral Maxillofac Surg. 2006;35:343-7.

https://doi.org/10.1016/j.ijom.2005.08.008

PMid:16280233 

2. Kim K, Brar P, Jakubowski J, Kaltman S, Lopez E. The use of corticosteroids and nonsteroidal antiinflammatory medication for the management of pain and inflammation after third molar surgery: a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:630-40.

https://doi.org/10.1016/j.tripleo.2008.11.005

PMid:19157919 

3. da Costa Araújo FA, de Santana Santos T, de Morais HH, Laureano Filho JR, de Oliveira E Silva ED, Vasconcellos RJ. Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery. J Craniomaxillofac Surg. 2012;40:e346-9.

https://doi.org/10.1016/j.jcms.2012.01.018

PMid:22421470 

4. Costa FW, Esses DF, de Barros Silva PG, Carvalho FS, Sá CD, Albuquerque AF, et al. Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials. Anesth Prog. 2015;62:57-63.

https://doi.org/10.2344/0003-3006-62.2.57

PMid:26061574 PMCid:PMC4462701

5. Markiewicz MR, Brady MF, Ding EL, Dodson TB. Corticosteroids reduce postoperative morbidity after third molar surgery: a systematic review and meta-analysis. J Oral Maxillofac Surg. 2008;66:1881-94.

https://doi.org/10.1016/j.joms.2008.04.022

PMid:18718396 

6. Ong KS, Seymour RA, Chen FG, Ho VC. Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. Int J Oral Maxillofac Surg. 2004;33:771-6.

https://doi.org/10.1016/j.ijom.2004.01.020

PMid:15556325 

7. Barbalho JC, Vasconcelos RJH, de Morais HH, Santos LAM, Almeida RAC, Rebêlo HL, et al. Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. Int J Oral Maxillofac Surg. 2017;42:236-42.

https://doi.org/10.1016/j.ijom.2016.10.011

PMid:27865630 

8. Pouchain EC, Costa FW, Bezerra TP, Soares EC. Comparative efficacy of nimesulide and ketoprofen on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study. Int J Oral Maxillofac Surg. 2015;44:876-84.

https://doi.org/10.1016/j.ijom.2014.10.026

PMid:25847016 

9. Trindade PA, Giglio FP, Colombini-Ishikiriama BL, Calvo AM, Modena KC, Ribeiro DA, et al. Comparison of oral versus sublingual piroxicam during postoperative pain management after lower third molar extraction. Int J Oral Maxillofac Surg. 2011;40:292-7.

https://doi.org/10.1016/j.ijom.2010.10.026

PMid:21144709 

10. Carnuccio R, Di Rosa M, Guerrasio B, Iuvone T, Sautebin L. Vasocortin: a novel glucocorticoid-induced anti-inflammatory protein. Br J Pharmacol. 1987;90:443-5.

https://doi.org/10.1111/j.1476-5381.1987.tb11193.x

PMid:2952212 PMCid:PMC1917188

11. Sautebin L, Carnuccio R, Ialenti A, Rosa M. Lipocortin and vasocortin: Two species of anti-inflammatory proteins mimicking the effects of glucocorticoids. Pharmacol Res. 1992;25:1-12.

https://doi.org/10.1016/S1043-6618(05)80058-1

PMid:1371190

12. Graziani F, D'Aiuto F, Arduino PG, Tonelli M, Gabriele M. Perioperative dexamethasone reduces post-surgical sequelae of wisdom tooth removal. A split-mouth randomized double-masked clinical trial. Int J Oral Maxillofac Surg. 2006;35:241-6.

https://doi.org/10.1016/j.ijom.2005.07.010

PMid:16188428 

13. Dionne RA, Berthold CW. Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry. Crit Rev Oral Biol Med. 2001;12:315-30.

https://doi.org/10.1177/10454411010120040301

PMid:11603504 

14. Gordon SM, Brahim JS, Rowan J, Kent A, Dionne RA. Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: replicate clinical trials in a tissue injury model. Clin Pharmacol Ther. 2002;72:175-83.

https://doi.org/10.1067/mcp.2002.126501

PMid:12189364 

15. Vadivelu N, Gowda AM, Urman RD, Jolly S, Kodumudi V, Maria M. Ketorolac tromethamine - routes and clinical implications. Pain Pract. 2015;15:175-93.

https://doi.org/10.1111/papr.12198

PMid:24738596 

16. Laureano Filho JR, Maurette PE, Allais M, Cotinho M, Fernandes C. Clinical comparative study of the effectiveness of two dosages of Dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Patol Oral Cir Bucal. 2008;13:e129-32.

PMid:18223530

17. Grant GM, Mehlisch DR. Intranasal ketorolac for pain secondary to third molar impaction surgery: a randomized, double-blind, placebo-controlled trial. J Oral Maxillofac Surg. 2010;68:1025-31.

https://doi.org/10.1016/j.joms.2009.10.023

PMid:20207062 

18. Alcântara CE, Falci SG, Oliveira-Ferreira F, Santos CR, Pinheiro ML. Pre-emptive effect of dexamethasone and methylprednisolone on pain, swelling, and trismus after third molar surgery: a split-mouth randomized triple-blind clinical trial. Int J Oral Maxillofac Surg. 2014;43:93-8.

https://doi.org/10.1016/j.ijom.2013.05.016

PMid:23810681 

19. Gopalraju P, Lalitha RM, Prasad K, Ranganath K. Comparative study of intravenous Tramadol versus Ketorolac for preventing postoperative pain after third molar surgery--a prospective randomized study. J Craniomaxillofac Surg. 2014;42:629-33.

https://doi.org/10.1016/j.jcms.2013.09.004

PMid:24269645 

20. Gutta R, Koehn CR, James LE. Does ketorolac have a preemptive analgesic effect? A randomized, double-blind, control study. J Oral Maxillofac Surg. 2013;71:2029-34.

https://doi.org/10.1016/j.joms.2013.06.220

PMid:23993224 

21. Trindade PAK, Giglio FPM, Colombini-Ishikiriama BL, Calvo AM, Modena KCS, Ribeiro DA, et al. Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:27-34.

https://doi.org/10.1016/j.tripleo.2011.05.027

PMid:22732846 

22. Dionne RA, Gordon SM, Rowan J, Kent A, Brahim JS. Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. J Oral Maxillofac Surg. 2003;61:997-1003.

https://doi.org/10.1016/S0278-2391(03)00310-0

PMid:12966473

23. Ueno A, Oh-ishi S. Critical roles for bradykinin and prostanoids in acute inflammatory reactions: a search using experimental animal models. Curr Drug Targets Inflamm Allergy. 2002;1:363-76.

https://doi.org/10.2174/1568010023344553

PMid:14561183 

24. Hargreaves KM, Costello A. Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probes. Clin Pharmacol Ther. 1990;48:168-78.

https://doi.org/10.1038/clpt.1990.132

PMid:2379387 

25. Mehra P, Reebye U, Nadershah M, Cottrell D. Efficacy of anti-inflammatory drugs in third molar surgery: a randomized clinical trial. Int J Oral Maxillofac Surg. 2013;42:835-42.

https://doi.org/10.1016/j.ijom.2013.02.017

PMid:23535007 

26. Chopra D, Rehan HS, Mehra P, Kakkar AK. A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. Int J Oral Maxillofac Surg. 2009;38:350-5.

https://doi.org/10.1016/j.ijom.2008.12.013

PMid:19168326 

27. Ilhan O, Agacayak KS, Gulsun B, Koparal M, Gunes N. A comparison of the effects of methylprednisolone and tenoxicam on pain, swelling, and trismus after impacted lower third molar extraction. Med Sci Monit. 2014;20:147-52.

https://doi.org/10.12659/MSM.890239

PMid:24473372 PMCid:PMC3915002

28. Paiva-Oliveira JG, Bastos PR, Cury Pontes ER, da Silva JC, Delgado JA, Oshiro-Filho NT. Comparison of the anti-inflammatory effect of dexamethasone and ketorolac in the extractions of third molars. Oral Maxillofac Surg. 2016;20:123-33.

https://doi.org/10.1007/s10006-015-0533-2

PMid:26572899 

29. Simone JL, Jorge WA, Horliana AC, Canaval TG, Tortamano IP. Comparative analysis of preemptive analgesic effect of dexamethasone and diclofenac following third molar surgery. Braz Oral Res. 2013;27:266-71.

https://doi.org/10.1590/S1806-83242013005000012

PMid:23657486 

30. Buesa-Bárez JM, Martin-Ares M, Martínez-Rodriguez N, Barona-Dorado C, Sanz-Alonso J, Cortés-Bretón-Brinkmann J, et al. Masseter and temporalis muscle electromyography findings after lower third molar extraction. Med Oral Patol Oral Cir Bucal. 2018;23:e92-7.

https://doi.org/10.4317/medoral.21992

PMid:29274163 PMCid:PMC5937843