Larsen MK, Kofod T, Duch K, Starch-Jensen T. Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars: a double-blind, split-mouth, randomised controlled trial. Med Oral Patol Oral Cir Bucal. 2021 Mar 1;26 (2):e156-63.


doi:10.4317/medoral.24094

https://dx.doi.org/doi:10.4317/medoral.24094


1. Bui CH, Seldin EB, Dodson TB. Types, frequencies, and risk factors for complications after third molar extraction. J Oral and Maxillofacial Surg. 2003;61:1379-89.

https://doi.org/10.1016/j.joms.2003.04.001

PMid:14663801 

 

2. Hargreaves KM, Costello A. Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probes. Clin Pharmacol Ther. 1990;48:168-78.

https://doi.org/10.1038/clpt.1990.132

PMid:2379387 

 

3. Larsen MK, Kofod T, Christiansen A-E, Starch-Jensen T. Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review. J Oral Maxillofac Res. 2018;9:1-21.

https://doi.org/10.5037/jomr.2018.9201

PMid:30116513 PMCid:PMC6090248

 

4. Majid OW, Mahmood WK. Effect of submucosal and intramuscular dexamethasone on postoperative sequelae after third molar surgery: Comparative study. Br J Oral Maxillofac Surg. 2011;49:647-52.

https://doi.org/10.1016/j.bjoms.2010.09.021

PMid:21035237 

 

5. Markiewicz MR, Brady MF, Ding EL, Dodson TB. Corticosteroids reduce postoperative morbidity after third molar surgery: a systematic review and meta-analysis. J Oral Maxillofacial Surg. 2008;66:1881-94.

https://doi.org/10.1016/j.joms.2008.04.022

PMid:18718396 

 

6. Herrera-Briones FJ, Prados Sánchez E, Reyes Botella C, Vallecillo Capilla M. Update on the use of corticosteroids in third molar surgery: systematic review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:342-51.

https://doi.org/10.1016/j.oooo.2012.02.027+A5

PMid:22902498 

 

7. Boonsiriseth K, Klongnoi B, Sirintawat N, Saengsirinavin C, Wongsirichat N. Comparative study of the effect of dexamethasone injection and consumption in lower third molar surgery. Int J Oral Maxillofac Surg. 2012;41:244-7.

https://doi.org/10.1016/j.ijom.2011.12.011

PMid:22209180 

 

8. Warraich R, Rana M, Faisal M, Rana M, Shaheen A, Gellrich NC. Evaluation of postoperative discomfort following third molar surgery using submucosal dexamethasone - A randomized observer blind prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:16-22.

https://doi.org/10.1016/j.oooo.2012.12.007

PMid:23453611 

 

9. Antunes AA, Avelar RL, Martins Neto EC, Frota R, Dias E. Effect of two routes of administration of dexamethasone on pain, edema, and trismus in impacted lower third molar surgery. Oral Maxillofac Surg. 2011;15:217-23.

https://doi.org/10.1007/s10006-011-0290-9

PMid:21845387 

 

10. Brucoli M, De Andreis M, Bonaso M, Boffano P, Benech A. Comparative assessment of dexamethasone administration routes for the management of postoperative symptoms following third molar surgery. J Stomatol Oral Maxillofac Surg. 2019;120:529-33.

https://doi.org/10.1016/j.jormas.2019.03.004

PMid:30885839 

 

11. Laureano Filho JR, Maurette PE, Allais M, Cotinho M, Fernandes C. Clinical comparative study of the effectiveness of two dosages of Dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Patol Oral Cir Bucal. 2008;13:129-32.

PMid:18223530

 

12. Lim D, Ngeow WC. A Comparative Study on the Efficacy of Submucosal Injection of Dexamethasone Versus Methylprednisolone in Reducing Postoperative Sequelae After Third Molar Surgery. J Oral Maxillofac Surg. 2017;75:2278-86.

https://doi.org/10.1016/j.joms.2017.05.033

PMid:28666096 

 

13. Ngeow WC, Lim D. Do Corticosteroids Still Have a Role in the Management of Third Molar Surgery?. Adv Ther. 2016;33:1105-39.

https://doi.org/10.1007/s12325-016-0357-y

PMid:27287853 PMCid:PMC4939150

 

14. Latt MM, Kiattavorncharoen S, Boonsiriseth K, Pairuchvej V, Wongsirichat N. The efficacy of dexamethasone injection on postoperative pain in lower third molar surgery. J Dent Anesth Pain Med. 2016;16:95.

https://doi.org/10.17245/jdapm.2016.16.2.95

PMid:28879301 PMCid:PMC5564088

 

15. AO A, Ndukwe K, Owotade F. Comparative Analgesic Effects of Ibuprofen, Celecoxib and Tramadol after third Molar Surgery: A Randomized Double Blind Controlled Trial. J Contemp Dent Pract. 2018;1:1334-40.

https://doi.org/10.5005/jp-journals-10024-2428

PMid:30602637 

 

16. Ibikunle AA, Adeyemo WL, Ladeinde AL. Oral health-related quality of life following third molar surgery with either oral administration or submucosal injection of prednisolone. Oral Maxillofac Surg. 2016;20:343-52.

https://doi.org/10.1007/s10006-016-0571-4

PMid:27447802 

 

17. Mojsa IM, Pokrowiecki R, Lipczynski K, Czerwonka D, Szczeklik K, Zaleska M. Effect of submucosal dexamethasone injection on postoperative pain, oedema, and trismus following mandibular third molar surgery: a prospective, randomized, double-blind clinical trial. Int J Oral Maxillofac Surg. 2017;46:524-30.

https://doi.org/10.1016/j.ijom.2016.11.006

PMid:28012633 

 

18. Bortoluzzi MC, Guollo A, Capella DL, Manfro R. Pain levels after third molar surgical removal: An evaluation of predictive variables. J Contemp Dent Pract. 2011;12:239-44.

https://doi.org/10.5005/jp-journals-10024-1041

PMid:22186857 

 

19. Phillips C, Gelesko S, Proffit WR, White RP. Recovery after third-molar surgery: The effects of age and sex. Am J Orthod Dentofacial Orthop. 2010;138:700.e1-8.

https://doi.org/10.1016/j.ajodo.2010.06.013

PMid:21130316 

 

20. Ali H, Mosleh M, Shawky M. Variables predictive of the intensity of postoperative pain following mandibular third molar surgery: a prospective study. Minerva Stomatol. 2018;67:111-6.

PMid:29879803

 

21. Tighe PJ, Riley JL, Fillingim RB. Sex differences in the incidence of severe pain events following surgery: A Review of 333,000 pain scores. Pain Med. 2014;15:1390-404.

https://doi.org/10.1111/pme.12498

PMid:25039440 PMCid:PMC4420194

 

22. Isola G, Matarese M, Ramaglia L, Cicciù M, Matarese G. Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial. Int J Oral Maxillofac Surg. 2019;48:1348-54.

https://doi.org/10.1016/j.ijom.2019.02.006

PMid:30853212 

 

23. UStün Y, Erdogan O, Esen E, Karsli ED. Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:535-9.

https://doi.org/10.1016/S1079-2104(03)00464-5

PMid:14600686

 

24. Agostinho CNLF, da Silva VC, Maia Filho EM, Cruz ML, Bastos EG. The efficacy of 2 different doses of dexamethasone to control postoperative swelling, trismus, and pain after third molar extractions. Gen Dent. 2014;62:e1-5.

PMid:25369393

 

25. López-Carriches C, Gómez-Font R, Martínez-González JM, Donado-Rodríguez M. Influence of smoking upon the postoperative course of lower third molar surgery. Med Oral Patol Oral Cir Bucal. 2006;11:E56-60.

PMid:16388296

 

26. Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Creminelli L, Santoro F. Assessing Postoperative Discomfort After Third Molar Surgery: A Prospective Study. J Oral Maxillofac Surg. 2007;65:901-17.

https://doi.org/10.1016/j.joms.2005.12.046

PMid:17448840 

 

27. Baqain ZH, Karaky AA, Sawair F, Khraisat A, Khaisat A, Duaibis R, et al. Frequency estimates and risk factors for postoperative morbidity after third molar removal: a prospective cohort study. J Oral Maxillofac Surg. 2008;66:2276-83.

https://doi.org/10.1016/j.joms.2008.06.047

PMid:18940492 

 

28. Phillips C, White RP, Shugars DA, Zhou X. Risk Factors Associated with Prolonged Recovery and Delayed Healing after Third Molar Surgery. J Oral Maxillofac Surg. 2003;61:1436-48.

https://doi.org/10.1016/j.joms.2003.08.003

PMid:14663809 

 

29. McGrath C, Comfort MB, Lo ECM, Luo Y. Changes in life quality following third molar surgery--the immediate postoperative period. Br Dent J. 2003;194:265-8.

https://doi.org/10.1038/sj.bdj.4809930

PMid:12658303 

 

30. Nesbitt LT. Minimizing complications from systemic glucocorticosteroid use. Dermatol Clin. 1995;13:925-39.

https://doi.org/10.1016/S0733-8635(18)30055-X

PMid:8785896