Cerqueira JMM, Pontes FSC, Santos-Silva AR, Almeida OPd, Costa RF, Fonseca FP, et al. Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population. Med Oral Patol Oral Cir Bucal. 2021 May 1;26 (3):e292-8.


doi:10.4317/medoral.24175

https://dx.doi.org/doi:10.4317/medoral.24175


1. Pontes FSC, Carnreiro JT, Fonseca FP, Silva TSP, Pontes HAR, Pinto DS. Squamous Cell Carcinoma of the Tongue and Floor of the Mouth: Analysis of Survival Rate and Independent Prognostic Factors in the Amazon Region. J Craniofac Surg. 2011;22:925-30.

https://doi.org/10.1097/SCS.0b013e31820fe1cb

PMid:21558919 

2. Capote-Moreno A, Brabyn P, Muñoz-Guerra MF, Sastre-Pérez J, Escorial-Hernandez V, Rodríguez-Campo FJ, et al. Oral squamous cell carcinoma: epidemiological study and risk factor assessment based on a 39-year series. Int J Oral Maxillofac Surg. 2020.

https://doi.org/10.1016/j.ijom.2020.03.009

PMid:32360101 

3. Bonzanini LIL, Soldera EB, Ortigara GB, Schulz RE, Antoniazzi RP, Ardenghi TM, et al. Clinical and sociodemographic factors that affect the quality of life of survivors of head and neck cancer. Support Care Cancer. 2020;28:1941-50.

https://doi.org/10.1007/s00520-019-05008-4

PMid:31375906 

4. Miyahara LAN, Pontes FSC, Burbano RMR, Conte Neto N, Guimarães DM, Fonseca FP, et al. PTEN allelic loss is an important mechanism in the late stage of development of oral leucoplakia into oral squamous cell carcinoma. Histopathology. 2018;72:330-38.

https://doi.org/10.1111/his.13381

PMid:28858374 

5. Wetzel SL, Wollenberg J. Oral Potentially Malignant Disorders. Dent Clin North Am. 2020;64:25-37.

https://doi.org/10.1016/j.cden.2019.08.004

PMid:31735231 

6. Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, et al. Potentially malignant disorders of the oral cavity and oral dysplasia: a systematic review and and meta-analysis of malignant transformation rate by subtype. Head Neck. 2020;42:539-55.

https://doi.org/10.1002/hed.26006

PMid:31803979 

7. Holmstrup P, Vedtofte P, Reibel J, Stoltze K. Long-term treatment outcome of oral premalignant lesions. Oral Oncol. 2006;42:461-74.

https://doi.org/10.1016/j.oraloncology.2005.08.011

PMid:16316774 

8. Pandey M, Thomas G, Somanathan T, Sankaranarayanan R, Abraham EK, Jacob BJ, et al. Evaluation of surgical excision of nonhomogeneous oral leukoplakia in a Screening Intervention Trial, Kerala, India. Oral Oncol. 2001;37:103-9.

https://doi.org/10.1016/S1368-8375(00)00070-1

PMid:11120491

9. Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:612-27.

https://doi.org/10.1016/j.oooo.2017.12.011

PMid:29396319 

10. Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016;45:155-66.

https://doi.org/10.1111/jop.12339

PMid:26189354 

11. Gandara-Vila P, Pérez-Sayans M, Suárez-Peñaranda JM, Gallas-Torreira M, Somoza-Martín J, Reboiras-López MD, et al. Survival study of leukoplakia malignant transformation in a region of northern Spain. Med Oral Patol Oral Cir Bucal. 2018;23:e413-20.

https://doi.org/10.4317/medoral.22326

PMid:29924757 PMCid:PMC6051679

12. Petti S. Pooled. Estimate of world leukoplakia prevalence: a systematic review. Oral Oncol. 2003;39:770-80.

https://doi.org/10.1016/S1368-8375(03)00102-7

PMid:13679200

13. Kujan O, Oliver RJ, Khattab A, Roberts SA, Thakker N, Sloan PP. Evaluation of a new binary system of grading oral epitelial dysplasia for prediction of malignant transformation. Oral Oncol. 2006;42:987-93.

https://doi.org/10.1016/j.oraloncology.2005.12.014

PMid:16731030 

14. Pinto AC, Caramês J, Francisco H, Chen A, Azul AM, Marques D. Malignant transformation rate of oral leukoplakia-systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;129:600-11.

https://doi.org/10.1016/j.oooo.2020.02.017

PMid:32249069 

15. Shearston K, Fateh B, Tai S, Hove D, Farah CS. Malignant transformation rate of oral leukoplakia in an Australian population. J Oral Pathol Med. 2019;48:530-37.

https://doi.org/10.1111/jop.12899

PMid:31172563 

16. Pontes HAR, de Aquino Xavier FC, da Silva TSP, Fonseca FP, Paiva HB, Pontes FSC, et al. Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study. J Oral Pathol Med. 2009;38:644-50.

https://doi.org/10.1111/j.1600-0714.2009.00787.x

PMid:19453843 

17. Awadallah M, Idle M, Patel K, Kademani D. Management update of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:628-36.

https://doi.org/10.1016/j.oooo.2018.03.010

PMid:29656948 

18. Lodi G, Franchini R, Warnakulasuriya S, Varoni EM, Sardella A, Kerr AR, et al. Interventions for treating oral leukoplakia to prevent oral cancer. Cochrane Database Syst Rev. 2016;7:CD001829.

https://doi.org/10.1002/14651858.CD001829.pub4

PMid:27471845

19. Ferreira AM, de Souza Lucena EE, de Oliveira TC, da Silveira EJD, de Oliveira PT, de Lima KC. Prevalence and factors associated with oral potentially malignant disorders in Brazil's rural workers. Oral Dis. 2016;22:536-42.

https://doi.org/10.1111/odi.12488

PMid:27090966 

20. Wu W, Wang Z, Zhou Z. Risk factors associated with malignant transformation in patients with oral leukoplakia in a chinese population: a retrospective study. J Oral Maxillofac Surg. 2019;77:2483-93.

https://doi.org/10.1016/j.joms.2019.08.002

PMid:31493377 

21. Qasrdashti AB, Habashi MS, Arasteh P, Torabi Ardakani M, Abdoli Z, Eghbali SS. Malignant transformation in leukoplakia and its associated factors in southern Iran: a hospital based experience. Iran J Public Health. 2017;46:1110-17.

PMid:28894713

22. Abadie WM, Partington EJ, Fowler CB, Schmalbach CE. Optimal management of proliferative verrucous leukoplakia: a systematic review of the literature. Otolaryngol Head Neck Surg. 2015;153:504-11.

https://doi.org/10.1177/0194599815586779

PMid:26044786 

23. Bagan J, Murillo-Cortes J, Leopoldo-Rodado M, Sanchis-Bielsa JM, Bagan L. Oral cancer on the gingiva in patients with proliferative leukoplakia: a study of 30 cases. J Periodontol. 2019;90:1142-8.

https://doi.org/10.1002/JPER.18-0620

PMid:31074011 

24. Munde A, Karle R. Proliferative verrucous leukoplakia: an update. J Cancer Res Ther. 2016;12:469-73.

https://doi.org/10.4103/0973-1482.151443

PMid:27461595 

25. Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI. Proliferative verrucous leukoplakia: diagnosis, management and current advances. Braz J Otorhinolaryngol. 2017;83:585-93.

https://doi.org/10.1016/j.bjorl.2016.12.005

PMid:28209441 

26. Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, et al. Oral leukoplakia and risk of progression to oral cancer: a population-based cohort study. Natl Cancer Inst. 2019.

https://doi.org/10.1093/jnci/djz238

PMid:31860085 PMCid:PMC7566351

27. Rock LD, Rosin MP, Zhang L, Chan B, Shariati B, Laronde DM. Characterization of epithelial oral dysplasia in non smokers: first steps towards precision medicine. Oral Oncol. 2018;78:119-25.

https://doi.org/10.1016/j.oraloncology.2018.01.028

PMid:29496039 PMCid:PMC5836799

28. Islam MN, Veenker KE, Cohen DM, Bhattacharyya I. Anatomic site based ploidy analysis of oral premalignant lesions. Head Neck Pathol. 2010;4:10-14.

https://doi.org/10.1007/s12105-009-0151-0

PMid:20237983 PMCid:PMC2825532

29. Castagnola P, Malacarne D, Scaruffi P, Maffei M, Donadini A, Di Nallo E, et al. Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue. BMC Cancer. 2011;11:445.

https://doi.org/10.1186/1471-2407-11-445

PMid:21995418 PMCid:PMC3229618