1. van Monsjou HS, Schaapveld M, Hamming-Vrieze O, de Boer JP, van den Brekel MWM, Balm AJM. Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: A population-based study. Oral Oncol. 2015;52:37-44.

https://doi.org/10.1016/j.oraloncology.2015.10.013

PMid:26553390 

2. Lin WJ, Jiang RS, Wu SH, Chen F, Liu SA. Smoking, Alcohol, and Betel Quid and Oral Cancer: A Prospective Cohort Study. J Oncol. 2011;2011:1-5.

https://doi.org/10.1155/2011/525976

PMid:21547265 PMCid:PMC3087410

3. Zavras AI, Yoon AJ, Chen MK, Lin CW, Yang SF. Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma. Ann Surg Oncol. 2011;18:1478-83.

https://doi.org/10.1245/s10434-010-1431-3

PMid:21128001 

4. Moleirinho A, Carneiro J, Matthiesen R, Silva RM, Amorim A, Azevedo L. Gains, losses and changes of function after gene duplication: Study of the metallothionein family. PLoS One. 2011;6:1-9.

https://doi.org/10.1371/journal.pone.0018487

PMid:21541013 PMCid:PMC3081807

5. Si M, Lang J. The roles of metallothioneins in carcinogenesis. J Hematol Oncol. 2018;11:1-20.

https://doi.org/10.1186/s13045-018-0645-x

PMID: 30139373

6. Forma E, Krzeslak A, Wilkosz J, Jozwiak P, Szymczyk A, Rozanski W, et al. Metallothionein 2A genetic polymorphisms and risk of prostate cancer in a Polish population. Cancer Genet. 2012;205:432-5.

https://doi.org/10.1016/j.cancergen.2012.05.005

PMid:22824183 

7. Dziegiel P. Expression of metallothioneins in tumor cells. Pol J Pathol. 2004;55:3-12.

PMID: 15195701

8. Cardoso S, Barbosa H, Candellori I, Loyola A, Aguiar M. Prognostic impact of metallothionein on oral squamous cell carcinoma. Virchows Arch. 2002;441:174-8.

https://doi.org/10.1007/s00428-001-0588-3

PMid:12189508 

9. Szelachowska J, Dziegiel P, Jelen-Krzeszewska J, Jelen M, Tarkowski R, Spytkowska B, et al. Correlation of metallothionein expression with clinical progression of cancer in the oral cavity. Anticancer Res. 2009;29:589-95.

PMID: 19331208

10. Brazão-Silva MT, Rodrigues MFS, Eisenberg ALA, Dias FL, de Castro LM, Nunes FD, et al. Metallothionein gene expression is altered in oral cancer and may predict metastasis and patient outcomes. Histopathology. 2015;67:358-67.

https://doi.org/10.1111/his.12660

PMid:25640883 

11. Verma M. Genome-wide association studies and epigenome-wide association studies go together in cancer control. Futur Oncol. 2016;12:1645-64.

https://doi.org/10.2217/fon-2015-0035

PMid:27079684 PMCid:PMC5551540

12. Krześlak A, Forma E, Jóźwiak P, Szymczyk A, Smolarz B, Romanowicz-Makowska H, et al. Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer. Clin Exp Med. 2014;14:107-13.

https://doi.org/10.1007/s10238-012-0215-4

PMid:23053628 PMCid:PMC3907692

13. Starska K, Krześlak A, Forma E, Olszewski J, Lewy-Trenda I, Osuch-Wójcikiewicz E, et al. Genetic polymorphism of metallothionein 2A and risk of laryngeal cancer in a Polish population. Med Oncol. 2014;31:75.

https://doi.org/10.1007/s12032-014-0075-8

PMid:24952512 

14. Yang L, Li H, Yu T, Zhao H, Cherian MG, Cai L, et al. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. Am J Physiol Endocrinol Metab. 2008;294:E987-92.

https://doi.org/10.1152/ajpendo.90234.2008

PMid:18349110 

15. Krześlak A, Forma E, Jóźwiak P, Szymczyk A, Smolarz B, Romanowicz-Makowska H, et al. Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer. Clin Exp Med. 2012;14:107-13.

https://doi.org/10.1007/s10238-012-0215-4

PMid:23053628 PMCid:PMC3907692

16. Yates A, Akanni W, Amode MR, Barrell D, Billis K, Carvalho-Silva D, et al. Ensembl 2016. Nucleic Acids Res. 2016;4:D710-6.

https://doi.org/10.1093/nar/gkv1157

PMid:26687719 PMCid:PMC4702834

17. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263-5.

https://doi.org/10.1093/bioinformatics/bth457

PMid:15297300 

18. Raudenska M, Gumulec J, Podlaha O, Sztalmachova M, Babula P, Eckschlager T, et al. Metallothionein polymorphisms in pathological processes. Metallomics. 2014;6:55-68.

https://doi.org/10.1039/C3MT00132F

PMid:24068159 

19. Liu D, Wang M, Tian T, Wang X-J, Kang H-F, Jin T-B, et al. Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population. Aging (Albany NY). 2017;9:547-55.

https://doi.org/10.18632/aging.101177

PMid:28228606 PMCid:PMC5361680

20. Wong RH, Huang CH, Yeh CB, Lee HS, Chien MH, Yang SF. Effects of Metallothionein-1 Genetic Polymorphism and Cigarette Smoking on the Development of Hepatocellular Carcinoma. Ann Surg Oncol. 2013;20:2088-95.

https://doi.org/10.1245/s10434-012-2456-6

PMid:22805858 

21. Cardoso SV, Silveira-Júnior JB, Machado VDC, De-Paula AMB, Loyola AM, Aguiar MCF. Expression of metallothionein and p53 antigens are correlated in oral squamous cell carcinoma. Anticancer Res. 2009;29:1189-93.

PMID: 19414363

22. Pontes H, de Aquino Xavier F, da Silva T, Fonseca F, Paiva H, Pontes F, et al. Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study. J Oral Pathol Med. 2009;38:644-50.

https://doi.org/10.1111/j.1600-0714.2009.00787.x

PMid:19453843 

23. Lim D, Jocelyn KMX, Yip GWC, Bay BH. Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells. Cancer Lett. 2009;276:109-17.

https://doi.org/10.1016/j.canlet.2008.10.038

PMid:19062161 

24. Lei L, Chang X, Rentschler G, Tian L, Zhu G, Chen X, et al. A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin. Toxicol Appl Pharmacol. 2012;265:373-9.

https://doi.org/10.1016/j.taap.2012.09.006

PMid:22995156 

25. Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet. 2002;3:285-98.

https://doi.org/10.1038/nrg775

PMid:11967553 

26. Mehus AA, Muhonen WW, Garrett SH, Somji S, Sens DA, Shabb JB. Quantitation of Human Metallothionein Isoforms: A Family of Small, Highly Conserved, Cysteine-rich Proteins. Mol Cell Proteomics. 2014;13:1020-33.

https://doi.org/10.1074/mcp.M113.033373

PMid:24493013 PMCid:PMC3977181

27. Manolio TA, Brooks LD, Collins FS. A HapMap harvest of insights into the genetics of common disease. J Clin Invest. 2008;118:1590-605.

https://doi.org/10.1172/JCI34772

PMid:18451988 PMCid:PMC2336881

28. Miles a T, Hawksworth GM, Beattie JH, Rodilla V. Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol. 2000;35:35-70.

https://doi.org/10.1080/10409230091169168

PMid:10755665 

29. Lee SS, Yang SF, Ho YC, Tsai CH, Chang YC. The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Oncol. 2008;44:180-6.

https://doi.org/10.1016/j.oraloncology.2007.01.019

PMid:17418620