Yanine N, Sabelle N, Vergara-Gárate V, Salazar J, Araya-Cabello I, Carrasco-Labra A, et al. Effect of antibiotic prophylaxis for preventing infectious complications following impacted mandibular third molar surgery. A randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2021 Nov 1;26 (6):e703-10.


doi:10.4317/medoral.24274

https://dx.doi.org/doi:10.4317/medoral.24274


1. Santosh P. Impacted Mandibular Third Molars: Review of Literature and a Proposal of a Combined Clinical and Radiological Classification. Ann Med Health Sci Res. 2015;5:229-34.

https://doi.org/10.4103/2141-9248.160177

PMid:26229709 PMCid:PMC4512113

2. Lacasa JM, Jimenez JA, Ferras V, Bossom M, Sola-Morales O, Garcia-Rey C, et al. Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5 mg). Int J Oral Maxillofac Surg. 2007;36:321-7.

https://doi.org/10.1016/j.ijom.2006.11.007

PMid:17229548 

3. Ren YF, Malmstrom HS. Effectiveness of antibiotic prophylaxis in third molar surgery: a meta-analysis of randomized controlled clinical trials. J Oral Maxillofac Surg. 2007;65:1909-21.

https://doi.org/10.1016/j.joms.2007.03.004

PMid:17884515 

4. Arteagoitia I, Diez A, Barbier L, Santamaria G, Santamaria J. Efficacy of amoxicillin/clavulanic acid in preventing infectious and inflammatory complications following impacted mandibular third molar extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:e11-8.

https://doi.org/10.1016/j.tripleo.2005.03.025

PMid:15953905 

5. Halpern LR, Dodson TB. Does prophylactic administration of systemic antibiotics prevent postoperative inflammatory complications after third molar surgery?. J Oral Maxillofac Surg. 2007;65:177-85.

https://doi.org/10.1016/j.joms.2006.10.016

PMid:17236918 

6. Poeschl PW, Eckel D, Poeschl E. Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity?. J Oral Maxillofac Surg. 2004;62:3-8.

https://doi.org/10.1016/j.joms.2003.05.004

PMid:14699540 

7. Monaco G, Tavernese L, Agostini R, Marchetti C. Evaluation of antibiotic prophylaxis in reducing postoperative infection after mandibular third molar extraction in young patients. J Oral Maxillofac Surg. 2009;67:1467-72.

https://doi.org/10.1016/j.joms.2008.12.066

PMid:19531419 

8. Limeres J, Sanroman JF, Tomas I, Diz P. Patients' perception of recovery after third molar surgery following postoperative treatment with moxifloxacin versus amoxicillin and clavulanic acid: a randomized, double-blind, controlled study. J Oral Maxillofac Surg. 2009;67:286-91.

https://doi.org/10.1016/j.joms.2008.06.061

PMid:19138601 

9. Kaczmarzyk T, Wichlinski J, Stypulkowska J, Zaleska M, Panas M, Woron J. Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery. Int J Oral Maxillofac Surg. 2007;36:417-22.

https://doi.org/10.1016/j.ijom.2006.12.003

PMid:17408924 

10. Kaczmarzyk T. Abuse of antibiotic prophylaxis in third molar surgeries. J Oral Maxillofac Surg. 2009;67:2551-2.

https://doi.org/10.1016/j.joms.2009.06.020

PMid:19837339 

11. Cervino G, Cicciù M, Biondi A, Bocchieri S, Herford AS, Laino L, et al. Antibiotic Prophylaxis on Third Molar Extraction: Systematic Review of Recent Data. Antibiotics (Basel). 2019;8:53.

https://doi.org/10.3390/antibiotics8020053

PMid:31052566 PMCid:PMC6627726

12. Blatt S, Al-Nawas B. A systematic review of latest evidence for antibiotic prophylaxis and therapy in oral and maxillofacial surgery. Infection. 2019;47:519-55.

https://doi.org/10.1007/s15010-019-01303-8

PMid:30945142 

13. Lodi G, Azzi L, Varoni EM, Pentenero M, Del Fabbro M, Carrassi A, et al. Antibiotics to prevent complications following tooth extractions. Cochrane Database Syst Rev. 2021;2:Cd003811.

https://doi.org/10.1002/14651858.CD003811.pub3

PMid:33624847 

14. Menon RK, Gopinath D, Li KY, Leung YY, Botelho MG. Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. Int J Oral Maxillofac Surg. 2019;48:263-73.

https://doi.org/10.1016/j.ijom.2018.08.002

PMid:30145064 

15. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. PLoS Med. 2010;7:e1000251.

https://doi.org/10.1371/journal.pmed.1000251

PMid:20352064 PMCid:PMC2844794

16. Khojastepour L, Khaghaninejad MS, Hasanshahi R, Forghani M, Ahrari F. Does the Winter or Pell and Gregory Classification System Indicate the Apical Position of Impacted Mandibular Third Molars? J Oral Maxillofac Surg. 2019;77:2222.e1-9.

https://doi.org/10.1016/j.joms.2019.06.004

PMid:31306615 

17. Blum IR. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002;31:309-17.

https://doi.org/10.1054/ijom.2002.0263

PMid:12190139 

18. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1999;20:250-78.

https://doi.org/10.1086/501620

PMid:10219875 

19. Lang MS, Gonzalez ML, Dodson TB. Do Antibiotics Decrease the Risk of Inflammatory Complications After Third Molar Removal in Community Practices?. J Oral Maxillofac Surg. 2017;75:249-55.

https://doi.org/10.1016/j.joms.2016.09.044

PMid:28341449 

20. Reiland MD, Ettinger KS, Lohse CM, Viozzi CF. Does Administration of Oral Versus Intravenous Antibiotics for Third Molar Removal Have an Effect on the Incidence of Alveolar Osteitis or Postoperative Surgical Site Infections?. J Oral Maxillofac Surg. 2017;75:1801-8.

https://doi.org/10.1016/j.joms.2017.03.038

PMid:28438595 

21. Arteagoitia I, Ramos E, Santamaria G, Barbier L, Alvarez J, Santamaria J. Amoxicillin/clavulanic acid 2000/125 mg to prevent complications due to infection following completely bone-impacted lower third molar removal: a clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:8-16.

https://doi.org/10.1016/j.oooo.2014.08.014

PMid:25442243 

22. Lopez-Cedrun JL, Pijoan JI, Fernandez S, Santamaria J, Hernandez G. Efficacy of amoxicillin treatment in preventing postoperative complications in patients undergoing third molar surgery: a prospective, randomized, double-blind controlled study. J Oral Maxillofac Surg. 2011;69:e5-14.

https://doi.org/10.1016/j.joms.2011.01.019

PMid:21470751 

23. Marcussen KB, Laulund AS, Jorgensen HL, Pinholt EM. A Systematic Review on Effect of Single-Dose Preoperative Antibiotics at Surgical Osteotomy Extraction of Lower Third Molars. J Oral Maxillofac Surg. 2016;74:693-703.

https://doi.org/10.1016/j.joms.2015.11.017

PMid:26706491 

24. Ramos E, Santamaria J, Santamaria G, Barbier L, Arteagoitia I. Do systemic antibiotics prevent dry socket and infection after third molar extraction? A systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:403-25.

https://doi.org/10.1016/j.oooo.2016.04.016

PMid:27499028 

25. Xue P, Wang J, Wu B, Ma Y, Wu F, Hou R. Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial. Br J Oral Maxillofac Surg. 2015;53:416-20.

https://doi.org/10.1016/j.bjoms.2015.02.001

PMid:25794779 

26. Ataoglu H, Oz GY, Candirli C, Kiziloglu D. Routine antibiotic prophylaxis is not necessary during operations to remove third molars. Br J Oral Maxillofac Surg. 2008;46:133-5.

https://doi.org/10.1016/j.bjoms.2006.11.005

PMid:17188409 

27. Sekhar CH, Narayanan V, Baig MF. Role of antimicrobials in third molar surgery: prospective, double blind,randomized, placebo-controlled clinical study. Br J Oral Maxillofac Surg. 2001;39:134-7.

https://doi.org/10.1054/bjom.2000.0557

PMid:11286448 

28. Al Harbi MJ, Alomaym MAA, Mohammed Aldohan MF, Fahad Alkurdi I. Necessity of Antibiotics to Reduce Inflammatory Complications after Third Molar Extractions: A Prospective Study. J Pharm Bioallied Sci. 2019;11:S13-s7.

https://doi.org/10.4103/JPBS.JPBS_232_18

PMid:30923425 PMCid:PMC6398309

29. Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Creminelli L, Santoro F. Assessing postoperative discomfort after third molar surgery: a prospective study. J Oral Maxillofac Surg. 2007;65:901-17.

https://doi.org/10.1016/j.joms.2005.12.046

PMid:17448840 

30. Cisneros JM, Rodriguez-Bano J, Mensa J, Trilla A, Cainzos M. [Antimicrobial prophylaxis in surgery]. Enferm Infecc Microbiol Clin. 2002;20:335-40.

https://doi.org/10.1016/S0213-005X(02)72812-7

PMid:12237000