Goñi FJ, Peña‑Oyarzún D, Torres VA, Reyes M. Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer. Med Oral Patol Oral Cir Bucal. 2021 Nov 1;26 (6):e729-37.



doi:10.4317/medoral.24528

https://dx.doi.org/doi:10.4317/medoral.24528


1.Dost F, Le Cao K, Ford PJ, Ades C, Farah CS. Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:343-52.

https://doi.org/10.1016/j.oooo.2013.09.017

PMid:24388536 

2.van der Waal I. Oral potentially malignant disorders: is malignant transformation predictable and preventable?. Med Oral Patol Oral Cir Bucal. 2014;19:e386-90.

https://doi.org/10.4317/medoral.20205

PMid:24905952 PMCid:PMC4119315

3.Speight PM. Update on oral epithelial dysplasia and progression to cancer. Head Neck Pathol. 2007;1:61-6.

https://doi.org/10.1007/s12105-007-0014-5

PMid:20614284 PMCid:PMC2807503

4.Mishra R. Biomarkers of oral premalignant epithelial lesions for clinical application. Oral Oncol. 2012;48:578-84.

https://doi.org/10.1016/j.oraloncology.2012.01.017

PMid:22342569 

5.Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell. 2012;149:1192-205.

https://doi.org/10.1016/j.cell.2012.05.012

PMid:22682243 

6.Nusse R. Wnt signaling. Cold Spring Harb Perspect Biol. 2012;4:a011163.

https://doi.org/10.1101/cshperspect.a011163

PMid:22550232 PMCid:PMC3331700

7.Ishida K, Ito S, Wada N, Deguchi H, Hata T, Hosoda M, et al. Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia. Mol Cancer. 2007;6:62.

https://doi.org/10.1186/1476-4598-6-62

PMid:17922924 PMCid:PMC2140063

8.Reyes M, Rojas-Alcayaga G, Maturana A, Aitken JP, Rojas C, Ortega AV. Increased nuclear beta-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia. Med Oral Patol Oral Cir Bucal. 2015;20:e540-6.

https://doi.org/10.4317/medoral.20341

PMid:26241451 PMCid:PMC4598921

9.Sato K, Okazaki Y, Tonogi M, Tanaka Y, Yamane GY. Expression of beta-catenin in rat oral epithelial dysplasia induced by 4-nitroquinoline 1-oxide. Oral Oncol. 2002;38:772-8.

https://doi.org/10.1016/S1368-8375(02)00044-1

PMid:12570056

10.Reyes M, Pena-Oyarzun D, Maturana A, Torres VA. Nuclear localization of beta-catenin and expression of target genes are associated with increased Wnt secretion in oral dysplasia. Oral Oncol. 2019;94:58-67.

https://doi.org/10.1016/j.oraloncology.2019.05.010

PMid:31178213 

11.Reyes M, Flores T, Betancur D, Peña-Oyarzún D, Torres VA. Wnt/β-Catenin Signaling in Oral Carcinogenesis. Int J Mol Sci. 2020;21:4682.

https://doi.org/10.3390/ijms21134682

PMid:32630122 PMCid:PMC7369957

12.Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 2004;20:781-810.

https://doi.org/10.1146/annurev.cellbio.20.010403.113126

PMid:15473860 

13.Iwai S, Katagiri W, Kong C, Amekawa S, Nakazawa M, Yura Y. Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2005;131:773-82.

https://doi.org/10.1007/s00432-005-0027-y

PMid:16163548 

14.Tsuchiya R, Yamamoto G, Nagoshi Y, Aida T, Irie T, Tachikawa T. Expression of adenomatous polyposis coli (APC) in tumorigenesis of human oral squamous cell carcinoma. Oral Oncol. 2004;40:932-40.

https://doi.org/10.1016/j.oraloncology.2004.04.011

PMid:15380172 

15.Prgomet Z, Axelsson L, Lindberg P, Andersson T. Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression. J Oral Pathol Med. 2015;44:776-84.

https://doi.org/10.1111/jop.12292

PMid:25459554 

16.Prgomet Z, Andersson T, Lindberg P. Higher expression of WNT5A protein in oral squamous cell carcinoma compared with dysplasia and oral mucosa with a normal appearance. Eur J Oral Sci. 2017;125:237-46.

https://doi.org/10.1111/eos.12352

PMid:28603941 PMCid:PMC5519933

17.Reyes M, Pena-Oyarzun D, Silva P, Venegas S, Criollo A, Torres VA. Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia. Faseb j. 2020;34:4009-25.

https://doi.org/10.1096/fj.201902345RR

PMid:31990106 

18.Santoro A, Pannone G, Papagerakis S, McGuff HS, Cafarelli B, Lepore S, et al. Beta-catenin and epithelial tumors: a study based on 374 oropharyngeal cancers. Biomed Res Int. 2014;2014:948264.

https://doi.org/10.1155/2014/948264

PMid:24511551 PMCid:PMC3912883

19.Lo Muzio L, Lo Russo L, Falaschini S, Ciavarella D, Pentenero M, Arduino P, et al. beta- and gamma-catenin expression in oral dysplasia. Oral Oncol. 2009;45:501-4.

https://doi.org/10.1016/j.oraloncology.2008.06.004

PMid:18715817 

20.Benhaj K, Akcali KC, Ozturk M. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Oncol Rep. 2006;15:701-7.

https://doi.org/10.3892/or.15.3.701

PMid:16465433 

21.Li J, Wu G, Xu Y, Ruan N, Chen Y, Zhang Q, et al. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma. Biomed Res Int. 2020;2020:2527643.

https://doi.org/10.1155/2020/2527643

PMid:32104684 PMCid:PMC7040395

22.Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013;73:502-7.

https://doi.org/10.1158/0008-5472.CAN-12-2258

PMid:23188502 

23.He S, Lu Y, Liu X, Huang X, Keller ET, Qian CN, et al. Wnt3a: functions and implications in cancer. Chin J Cancer. 2015;34:554-62.

https://doi.org/10.1186/s40880-015-0052-4

PMid:26369691 PMCid:PMC4593336

24.Wang B, Tang Z, Gong H, Zhu L, Liu X. Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer. Biosci Rep. 2017;37:BSR20171092.

https://doi.org/10.1042/BSR20171092

PMid:29054966 PMCid:PMC5705780

25.Wang T, Liu X, Wang J. Up-regulation of Wnt5a inhibits proliferation and migration of hepatocellular carcinoma cells. J Cancer Res Ther. 2019;15:904-8.

https://doi.org/10.4103/jcrt.JCRT_886_18

PMid:31436250 

26.Schell MJ, Yang M, Teer JK, Lo FY, Madan A, Coppola D, et al. A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC. Nat Commun. 2016;7:11743.

https://doi.org/10.1038/ncomms11743

PMid:27302369 PMCid:PMC4912618

27.Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, et al. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene. 2002;21:4863-71.

https://doi.org/10.1038/sj.onc.1205591

PMid:12101426 

28.Cong F, Varmus H. Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc Natl Acad Sci U S A. 2004;101:2882-7.

https://doi.org/10.1073/pnas.0307344101

PMid:14981260 PMCid:PMC365714

29.Caspi M, Zilberberg A, Eldar-Finkelman H, Rosin-Arbesfeld R. Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner. Oncogene. 2008;27:3546-55.

https://doi.org/10.1038/sj.onc.1211026

PMid:18223684