Grossi JR, Parra M, Benalcázar-Jalkh EB, Giovanini AF, Zielak JC, Sebstiani AM, et al. Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants. Med Oral Patol Oral Cir Bucal. 2022 Mar 1;27 (2):e174-80.
doi:10.4317/medoral.25164
https://dx.doi.org/doi:10.4317/medoral.25164
1. Bonfante EA, Jimbo R, Witek L, Tovar N, Neiva R, Torroni A, et al. Biomaterial and biomechanical considerations to prevent risks in implant therapy. Periodontol 2000. 2019;81:139-51.
https://doi.org/10.1111/prd.12288
PMid:31407440
2. Coelho PG, Jimbo R, Tovar N, Bonfante EA. Osseointegration: hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales. Dent Mater. 2015;31:37-52.
https://doi.org/10.1016/j.dental.2014.10.007
PMid:25467952
3. Goiato MC, dos Santos DM, Santiago JF Jr, Moreno A, Pellizzer EP. Longevity of dental implants in type IV bone: a systematic review. Int J Oral Maxillofac Surg. 2014;43:1108-16.
https://doi.org/10.1016/j.ijom.2014.02.016
PMid:24679842
4. Staedt H, Rossa M, Lehmann KM, Al-Nawas B, Kammerer PW, Heimes D. Potential risk factors for early and late dental implant failure: a retrospective clinical study on 9080 implants. Int J Implant Dent. 2020;6:81.
https://doi.org/10.1186/s40729-020-00276-w
PMid:33251566 PMCid:PMC7701040
5. Marin C, Jimbo R, Lorenzoni FC, Witek L, Teixeira H, Bonfante E, et al. Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen: A Pilot Study in the Sheep Mandible. Int J Dent. 2013;2013:296391.
https://doi.org/10.1155/2013/296391
PMid:24285956 PMCid:PMC3826298
6. Osagie-Clouard L, Sanghani A, Coathup M, Briggs T, Bostrom M, Blunn G. Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation. Bone Joint Res. 2017;6:14-21.
https://doi.org/10.1302/2046-3758.61.BJR-2016-0085.R1
PMid:28062525 PMCid:PMC5227055
7. Yoo D, Tovar N, Jimbo R, Marin C, Anchieta RB, Machado LS, et al. Increased osseointegration effect of bone morphogenetic protein 2 on dental implants: an in vivo study. J Biomed Mater Res A. 2014;102:1921-7.
https://doi.org/10.1002/jbm.a.34862
PMid:23853058
8. Klein IE. The effect of thyrocalcitonin and growth hormones on bone metabolism. J Prosthet Dent. 1975;33:365-79.
https://doi.org/10.1016/S0022-3913(75)80032-1
PMid:804036
9. Ohlsson C, Vidal O. Effects of growth hormone and insulin-like growth factors on human osteoblasts. Eur J Clin Invest. 1998;28:184-6.
https://doi.org/10.1046/j.1365-2362.1998.00266.x
PMid:9568462
10. Bak B, Andreassen TT. The effect of growth hormone on fracture healing in old rats. Bone. 1991;12:151-4.
https://doi.org/10.1016/8756-3282(91)90037-J
PMid:1910956
11. Kim Y, Hong JW, Chung YS, Kim SW, Cho YW, Kim JH, et al. Efficacy and safety of sustained-release recombinant human growth hormone in Korean adults with growth hormone deficiency. Yonsei Med J. 2014;55:1042-8.
https://doi.org/10.3349/ymj.2014.55.4.1042
PMid:24954335 PMCid:PMC4075365
12. Varkey M, Gittens SA, Uludag H. Growth factor delivery for bone tissue repair: an update. Expert Opin Drug Deliv. 2004;1:19-36.
https://doi.org/10.1517/17425247.1.1.19
PMid:16296718
13. Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC. Growth hormone and bone. Endocr Rev. 1998;19:55-79.
https://doi.org/10.1210/edrv.19.1.0324
PMid:9494780
14. Tresguerres IF, Blanco L, Clemente C, Tresguerres JA. Effects of local administration of growth hormone in peri-implant bone: an experimental study with implants in rabbit tibiae. Int J Oral Maxillofac Implants. 2003;18:807-11.
PMid:14696655
15. Nielsen HM, Bak B, Jorgensen PH, Andreassen TT. Growth hormone promotes healing of tibial fractures in the rat. Acta Orthop Scand. 1991;62:244-7.
https://doi.org/10.3109/17453679108993601
PMid:2042466
16. Gomez-Moreno G, Cutando A, Arana C, Worf CV, Guardia J, Munoz F, et al. The effects of growth hormone on the initial bone formation around implants. Int J Oral Maxillofac Implants. 2009;24:1068-73.
PMid:20162111
17. Stenport VF, Olsson B, Morberg P, Tornell J, Johansson CB. Systemically administered human growth hormone improves initial implant stability: an experimental study in the rabbit. Clin Implant Dent Relat Res. 2001;3:135-41.
https://doi.org/10.1111/j.1708-8208.2001.tb00133.x
PMid:11799703
18. Guicheux J, Gauthier O, Aguado E, Pilet P, Couillaud S, Jegou D, et al. Human growth hormone locally released in bone sites by calcium-phosphate biomaterial stimulates ceramic bone substitution without systemic effects: a rabbit study. J Bone Miner Res. 1998;13:739-48.
https://doi.org/10.1359/jbmr.1998.13.4.739
PMid:9556073
19. Munoz F, Lopez-Pena M, Mino N, Gomez-Moreno G, Guardia J, Cutando A. Topical application of melatonin and growth hormone accelerates bone healing around dental implants in dogs. Clin Implant Dent Relat Res. 2012;14:226-35.
https://doi.org/10.1111/j.1708-8208.2009.00242.x
PMid:19793331
20. Tresguerres IF, Alobera MA, Baca R, Tresguerres JA. Histologic, morphometric, and densitometric study of peri-implant bone in rabbits with local administration of growth hormone. Int J Oral Maxillofac Implants. 2005;20:193-202.
PMid:15839112
21. Tresguerres IF, Clemente C, Donado M, Gomez-Pellico L, Blanco L, Alobera MA, et al. Local administration of growth hormone enhances periimplant bone reaction in an osteoporotic rabbit model. Clin Oral Implants Res. 2002;13:631-6.
https://doi.org/10.1034/j.1600-0501.2002.130609.x
PMid:12519338
22. Calvo-Guirado JL, Mate-Sanchez J, Delgado-Ruiz R, Ramirez-Fernandez MP, Cutando-Soriano A, Pena M. Effects of growth hormone on initial bone formation around dental implants: a dog study. Clin Oral Implants Res. 2011;22:587-93.
https://doi.org/10.1111/j.1600-0501.2010.02007.x
PMid:21121954
23. Bak B, Jorgensen PH, Andreassen TT. The stimulating effect of growth hormone on fracture healing is dependent on onset and duration of administration. Clin Orthop Relat Res. 1991;(264):295-301.
https://doi.org/10.1097/00003086-199103000-00037
PMid:1997248
24. Alenezi A, Chrcanovic B, Wennerberg A. Effects of Local Drug and Chemical Compound Delivery on Bone Regeneration Around Dental Implants in Animal Models: A Systematic Review and Meta-Analysis. Int J Oral Maxillofac Implants. 2018;33:e1-e18.
https://doi.org/10.11607/jomi.6333
PMid:29340346
25. Gabet Y, Kohavi D, Voide R, Mueller TL, Muller R, Bab I. Endosseous implant anchorage is critically dependent on mechanostructural determinants of peri-implant bone trabeculae. J Bone Miner Res. 2010;25:575-83.
https://doi.org/10.1359/jbmr.090808
PMid:19653813
26. Beutel BG, Danna NR, Granato R, Bonfante EA, Marin C, Tovar N, et al. Implant design and its effects on osseointegration over time within cortical and trabecular bone. J Biomed Mater Res B Appl Biomater. 2016;104:1091-7.
https://doi.org/10.1002/jbm.b.33463
PMid:26034012
27. Wennerberg A, Albrektsson T. Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Implants Res. 2009;20 Suppl 4:172-84.
https://doi.org/10.1111/j.1600-0501.2009.01775.x
PMid:19663964
28. Martin-Monge E, Tresguerres IF, Clemente C, Tresguerres JA. Local Application of Growth Hormone to Enhance Osseointegration in Osteoporotic Bones: A Morphometric and Densitometric Study. Int J Oral Maxillofac Implants. 2017;32:751-8.
https://doi.org/10.11607/jomi.5320
PMid:28708907
29. Theyse LF, Oosterlaken-Dijksterhuis MA, van Doorn J, Dhert WJ, Hazewinkel HA. Growth hormone stimulates bone healing in a critical-sized bone defect model. Clin Orthop Relat Res. 2006;446:259-67.
https://doi.org/10.1097/01.blo.0000203490.21206.7f
PMid:16505713
30. Eriksen EF, Kassem M, Langdahl B. Growth hormone, insulin-like growth factors and bone remodelling. Eur J Clin Invest. 1996;26:525-34.
https://doi.org/10.1046/j.1365-2362.1996.00292.x
PMid:8864413