Ávila-Oliver C, Veloso V, Laissle G, Rojas AM, Verdugo-Paiva F, Ramos-Rojas J. TEfficacy of platelet-rich-fibrin for the treatment of alveolar osteitis: a systematic review and meta-analysist. Med Oral Patol Oral Cir Bucal. 2025 May 1;30 (3):e345-53.


doi:10.4317/medoral.26801

https://dx.doi.org/doi:10.4317/medoral.26801


1. Burgoyne CC, Giglio JA, Reese SE, Sima AP, Laskin DM. The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. J Oral Maxillofac Surg. 2010;68:144-8.

https://doi.org/10.1016/j.joms.2009.06.033

PMid:20006169 

2. Chow O, Wang R, Ku D, Huang W. Alveolar Osteitis: A Review of Current Concepts. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg. 2020;78:1288-96.

https://doi.org/10.1016/j.joms.2020.03.026

PMid:32348729 

3. Blum I. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002;31:309-17.

https://doi.org/10.1054/ijom.2002.0263

PMid:12190139 

4. Nusair Y, Younis M. Prevalence, clinical picture, and risk factors of dry socket in a Jordanian dental teaching center. J Contemp Dent Pr. 2007;8:53-63.

https://doi.org/10.5005/jcdp-8-3-53

PMid:17351682

5. Vezeau PJ. Dental extraction wound management: medicating postextraction sockets. J Oral Maxillofac Surg. 2000;58:531-7.

https://doi.org/10.1016/S0278-2391(00)90016-8

PMid:10800909 

6. Øyri H, Jonsdottir O, Jensen JL, Bjørnland T. The use of a tetracycline drain reduces alveolar osteitis: a randomized prospective trial of third molar surgery under local anesthetics and without the use of systemic antibiotics. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;128:205-12.

https://doi.org/10.1016/j.oooo.2018.12.004

PMid:31221615 

7. Daly BJ, Sharif MO, Jones K, Worthington HV, Beattie A. Local interventions for the management of alveolar osteitis (dry socket). Cochrane Database Syst Rev. 2022;26;9:CD006968.

https://doi.org/10.1002/14651858.CD006968.pub3

PMid:36156769 PMCid:PMC9511819

8. Keshini MP, Shetty SK, Sundar S, Chandan SN, Manjula S. Assessment of Healing Using Alvogyl and Platelet Rich Fibrin in Patients with Dry Socket - An Evaluative Study. Ann Maxillofac Surg. 2020;10:320-4.

https://doi.org/10.4103/ams.ams_259_19

PMid:33708574 PMCid:PMC7944002

9. Tasoulas J, Daskalopoulos A, Droukas C, Nonni A, Nikitakis NG. An unusual microscopic pattern of foreign body reaction as a complication of dry socket management. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:e118-23.

https://doi.org/10.1016/j.oooo.2017.08.010

PMid:29104032 

10. King EM, Cerajewska TL, Locke M, Claydon NC, Davies M, West NX. The efficacy of plasma rich in growth factors for the treatment of alveolar osteitis: a randomized controlled trial. J Oral Maxillofac Surg. 2018;76:1150-9.

https://doi.org/10.1016/j.joms.2017.12.025

PMid:29382467 

11. Miron RJ, Fujioka-Kobayashi M, Moraschini V, Zhang Y, Gruber R, Wang HL. Efficacy of platelet-rich fibrin on bone formation, part 1: Alveolar ridge preservation. Int J Oral Implantol (Berl). 2021;14:181-94.

PMid:34006080

12. Giudice A, Barone S, Giudice C, Bennardo F, Fortunato L. Can platelet-rich fibrin improve healing after surgical treatment of medication-related osteonecrosis of the jaw? A pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126:390-403.

https://doi.org/10.1016/j.oooo.2018.06.007

PMid:30108028 

13. MacGregor A. Aetiology of dry socket: a clinical investigation. Br J Oral Surg. 1968;6:49-58.

https://doi.org/10.1016/S0007-117X(68)80026-5

PMid:5244107 

14. Asutay F, Yolcu Ü, Geçör O, Acar A, Öztürk S, Malkoç S. An evaluation of effects of platelet‑rich‑fibrin on postoperative morbidities after lower third molar surgery. Niger J Clin Pract. 2017;20:1531-6.

https://doi.org/10.4103/1119-3077.181400

PMid:29378982 

15. Rastogi S, Choudhury R, Kumar A, Manjunath S, Sood A, Upadhyay H. Versatility of platelet rich fibrin in the management of alveolar osteitis-A clinical and prospective study. J Oral Biol Craniofac Res. 2018;8:188-93.

https://doi.org/10.1016/j.jobcr.2017.05.002

PMid:30191106 PMCid:PMC6107907

16. Bao MZ, Liu W, Yu SR, Men Y, Han B, Li CJ. Application of platelet-rich fibrin on mandibular third molar extraction: systematic review and Meta-analysis. Hua Xi Kou Qiang Yi Xue Za Zhi Huaxi Kouqiang Yixue Zazhi West China J Stomatol. 2021;39:605-11.

PMID: 34636211

17. Taberner-Vallverdú M, Sánchez-Garcés MÁ, Gay-Escoda C. Efficacy of different methods used for dry socket prevention and risk factor analysis: A systematic review. Med Oral Patol Oral Cir Bucal. 2017;22:e750-e8.

https://doi.org/10.4317/medoral.21705

PMid:29053647 PMCid:PMC5813994

18. Xiang X, Shi P, Zhang P, Shen J, Kang J. Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis. BMC Oral Health. 2019;19:163.

https://doi.org/10.1186/s12903-019-0824-3

PMid:31345203 PMCid:PMC6659259

19. Laforgia A, Inchingolo AD, Riccaldo L, Avantario P, Buongiorno S, Malcangi G, et al. The Use of Platelet-Rich Fibrin (PRF) in the Management of Dry Socket: A Systematic Review. Int J Mol Sci. 2024;25:10069.

https://doi.org/10.3390/ijms251810069

PMid:39337554 PMCid:PMC11432458

20. Eshghpour M, Dastmalchi P, Nekooei AH, Nejat A. Effect of platelet-rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: a double-blinded randomized clinical trial. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg. 2014;72:1463-7.

https://doi.org/10.1016/j.joms.2014.03.029

PMid:25037182 

21. Iqbal N, Khalid MU, Janjua OS, Zafar KJ, Usama MM. Assessment of Dry Socket after Mandibular Third Molar Surgery Using Platelet-Rich Fibrin - A Prospective Clinical Study. J Coll Physicians Surg Pak JCPSP. 2023;33:504-8.

https://doi.org/10.29271/jcpsp.2023.05.504

PMid:37190682 

22. Unsal H, H Erbasar GN. Evaluation of the Effect of Platelet-Rich Fibrin on the Alveolar Osteitis Incidence and Periodontal Probing Depth after Extracting Partially Erupted Mandibular Third Molars Extraction. Niger J Clin Pract. 2018;21:201-5.

PMID: 2946505

23. Chakravarthi S. Platelet rich fibrin in the management of established dry socket. J Korean Assoc Oral Maxillofac Surg. 2017;43:160-5.

https://doi.org/10.5125/jkaoms.2017.43.3.160

PMid:28770156 PMCid:PMC5529189

24. Yüce E, Kömerik N. Potential effects of advanced platelet rich fibrin as a wound-healing accelerator in the management of alveolar osteitis: A randomized clinical trial. Niger J Clin Pract. 2019;22:1189-95.

https://doi.org/10.4103/njcp.njcp_27_19

PMid:31489852 

25. Sharma A, Aggarwal N, Rastogi S, Choudhury R, Tripathi S. Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). Eur J Dent. 2017;11:508-13.

https://doi.org/10.4103/ejd.ejd_346_16

PMid:29279679 PMCid:PMC5727738

26. Hussain I, Singh S, Jain H, Kumar S, Anand KR, Batool N, et al. A prospective randomised clinical study on evaluation of platelet-rich fibrin versus zinc oxide eugenol in the management of alveolar osteitis. Oral Surg. 2018;11:41-9.

https://doi.org/10.1111/ors.12299

PMid:

27. He Y, Chen J, Huang Y, Pan Q, Nie M. Local Application of Platelet-Rich Fibrin During Lower Third Molar Extraction Improves Treatment Outcomes. J Oral Maxillofac Surg. 2017;75:2497-506.

https://doi.org/10.1016/j.joms.2017.05.034

PMid:28672135 

28. Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, et al. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Investig. 2017;21:1913-27.

https://doi.org/10.1007/s00784-017-2133-z

PMid:28551729 

29. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62:1006-12.

https://doi.org/10.1016/j.jclinepi.2009.06.005

PMid:19631508 

30. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

https://doi.org/10.1136/bmj.l4898

PMid:31462531 

31. Brozek JL, Akl EA, Alonso-Coello P, Lang D, Jaeschke R, Williams JW, et al. GRADE Working Group. Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy. 2009;64:669-77.

https://doi.org/10.1111/j.1398-9995.2009.01973.x

PMid:19210357 

32. Wang XL. Comparison of Platelet-Rich Fibrin and Iodoform Gauze in the Treatment of Localized Alveolitis. J Oral Maxillofac Surg. 2023;81:1155-60.

https://doi.org/10.1016/j.joms.2023.06.005

PMid:37364857 

33. La Rosa GRM, Marcianò A, Priolo CY, Peditto M, Pedullà E, Bianchi A. Effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis: a scoping review. Clin Oral Investig. 2023;27:3321-30.

https://doi.org/10.1007/s00784-023-05012-3

PMid:37014504 PMCid:PMC10329583