1. Duarte-Andrade FF, Vitório JG, Pereira T, Gomes CC, Gomez RS. A review of the molecular profile of benign and malignant odontogenic lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;129:357-68.

https://doi.org/10.1016/j.oooo.2019.12.017

PMid:32035859 

2. Vered M, Peleg O, Taicher S, Buchner A. The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts. J Oral Pathol Med. 2009;38:597-604.

https://doi.org/10.1111/j.1600-0714.2009.00778.x

PMid:19473442 

3. Trujillo-González D, Villarroel-Dorrego M, Toro R, Vigil G, Pereira-Prado V, Bologna-Molina R. Decompression induces inflammation but do not modify cell proliferation and apoptosis in odontogenic keratocyst. J Clin Exp Dent. 2022;14:e100-e6.

https://doi.org/10.4317/jced.59096

PMid:35070131 PMCid:PMC8760963

4. Diniz MG, Gomes CC, de Sousa SF, Xavier GM, Gomez RS. Oncogenic signalling pathways in benign odontogenic cysts and tumours. Oral Oncol. 2017;72:165-73.

https://doi.org/10.1016/j.oraloncology.2017.07.021

PMid:28797453 

5. Strasser A, Vaux DL. Cell Death in the Origin and Treatment of Cancer. Mol Cell. 2020;78:1045-54.

https://doi.org/10.1016/j.molcel.2020.05.014

PMid:32516599 

6. Tenório JR, Santana T, Queiroz SI, de Oliveira DH, Queiroz LM. Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax. Med Oral Patol Oral Cir Bucal. 2018;23:e120-e5.

https://doi.org/10.4317/medoral.22019

PMid:29476674 PMCid:PMC5911354

7. Escobar E, Gómez-Valenzuela F, Peñafiel C, Chimenos-Küstner E, Pérez-Tomás R. Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts. J Clin Exp Dent. 2023;15:e125-e34.

PMid:36911151

8. Melean LP, Guerrero LM, Lopez L. 5-fluorouacil in the treatment of odontogenic keratocysts-incidence of recurrence and inferior alveolar nerve paresthesia: a systematic review. Oral Maxillofac Surg. 2023;27:489-96.

https://doi.org/10.1007/s10006-022-01090-x

PMid:35715708 

9. Al-Moraissi EA, Kaur A, Gomez RS, Ellis E, 3rd. Effectiveness of different treatments for odontogenic keratocyst: a network meta-analysis. Int J Oral Maxillofac Surg. 2023;52:32-43.

https://doi.org/10.1016/j.ijom.2022.09.004

PMid:36150944 

10. Ledderhof NJ, Caminiti MF, Bradley G, Lam DK. Topical 5-Fluorouracil is a Novel Targeted Therapy for the Keratocystic Odontogenic Tumor. J Oral Maxillofac Surg. 2017;75:514-24.

https://doi.org/10.1016/j.joms.2016.09.039

PMid:27789270 

11. Peters MD, Godfrey CM, Khalil H, McInerney P, Parker D, Soares CB. Guidance for conducting systematic scoping reviews. Int J Evid Based Healthc. 2015;13:141-6.

https://doi.org/10.1097/XEB.0000000000000050

PMid:26134548 

12. Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, et al. Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evid Synth. 2020;18:2127-33.

https://doi.org/10.11124/JBISRIR-D-19-00099

PMid:33038125 

13. Kimi K, Kumamoto H, Ooya K, Motegi K. Immunohistochemical analysis of cell-cycle- and apoptosis-related factors in lining epithelium of odontogenic keratocysts. J Oral Pathol Med. 2001;30:434-42.

https://doi.org/10.1034/j.1600-0714.2001.300709.x

PMid:11488422 

14. Soluk Tekkeşın M, Mutlu S, Olgaç V. Expressions of bax, bcl-2 and Ki-67 in odontogenic keratocysts (Keratocystic Odontogenic Tumor) in comparison with ameloblastomas and radicular cysts. Turk Patoloji Derg. 2012;28:49-55.

https://doi.org/10.5146/tjpath.2012.01097

PMid:22207432 

15. Rangiani A, Motahhary P. Evaluation of bax and bcl-2 expression in odontogenic keratocysts and orthokeratinized odontogenic cysts: A comparison of two cysts. Oral Oncol. 2009;45:e41-4.

https://doi.org/10.1016/j.oraloncology.2008.12.007

PMid:19362040 

16. Kolář Z, Geierová M, Bouchal J, Pazdera J, Zbořil V, Tvrdý P. Immunohistochemical analysis of the biological potential of odontogenic keratocysts. J Oral Pathol Med. 2006;35:75-80.

https://doi.org/10.1111/j.1600-0714.2006.00382.x

PMid:16430736 

17. Ghorbani N, Yaghubi R, Davoodi J, Pahlavan S. How does caspases regulation play role in cell decisions? apoptosis and beyond. Mol Cell Biochem. 2024;479:1599-613.

https://doi.org/10.1007/s11010-023-04870-5

PMid:37976000 

18. Kale J, Osterlund EJ, Andrews DW. BCL-2 family proteins: changing partners in the dance towards death. Cell Death Differ. 2018;25:65-80.

https://doi.org/10.1038/cdd.2017.186

PMid:29149100 PMCid:PMC5729540

19. Nano M, Montell DJ. Apoptotic signaling: Beyond cell death. Semin Cell Dev Biol. 2024;156:22-34.

https://doi.org/10.1016/j.semcdb.2023.11.002

PMid:37988794 

20. Qian S, Wei Z, Yang W, Huang J, Yang Y, Wang J. The role of BCL-2 family proteins in regulating apoptosis and cancer therapy. Front Oncol. 2022;12:985363.

https://doi.org/10.3389/fonc.2022.985363

PMid:36313628 PMCid:PMC9597512

21. Singh R, Letai A, Sarosiek K. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nature Rev Mol Cell Biol. 2019;20:175-93.

https://doi.org/10.1038/s41580-018-0089-8

PMid:30655609 PMCid:PMC7325303

22. Singh R, Letai A, Sarosiek K. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol. 2019;20:175-93.

https://doi.org/10.1038/s41580-018-0089-8

PMid:30655609 PMCid:PMC7325303

23. Suzuki T, Kumamoto H, Kunimori K, Ooya K. Immunohistochemical analysis of apoptosis-related factors in lining epithelium of radicular cysts. J Oral Pathol Med. 2005;34:46-52.

https://doi.org/10.1111/j.1600-0714.2004.00248.x

PMid:15610406 

24. Kolár Z, Geierová M, Bouchal J, Pazdera J, Zboril V, Tvrdý P. Immunohistochemical analysis of the biological potential of odontogenic keratocysts. J Oral Pathol Med. 2006;35:75-80.

https://doi.org/10.1111/j.1600-0714.2006.00382.x

PMid:16430736 

25. Gomes CC, Guimarães LM, Diniz MG, Gomez RS. Molecular alterations in odontogenic keratocysts as potential therapeutic targets. J Oral Pathol Med. 2017;46:877-82.

https://doi.org/10.1111/jop.12591

PMid:28489259 

26. Mendes RA, Carvalho JF, van der Waal I. Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment - an overview. Oral Oncol. 2010;46:19-24.

https://doi.org/10.1016/j.oraloncology.2009.10.009

PMid:20004133 

27. Kichi E, Enokiya Y, Muramatsu T, Hashimoto S, Inoue T, Abiko Y, et al. Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts. J Oral Pathol Med. 2005;34:280-6.

https://doi.org/10.1111/j.1600-0714.2005.00314.x

PMid:15817071 

28. Singh AK, Khanal N, Chaulagain R, Bhujel N, Singh RP. How effective is 5-Fluorouracil as an adjuvant in the management of odontogenic keratocyst? A systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2022;60:746-54.

https://doi.org/10.1016/j.bjoms.2022.02.001

PMid:35314081 

29. Roberts AW, Davids MS, Pagel JM, Kahl BS, Puvvada SD, Gerecitano JF, et al. Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia. N Engl J Med. 2016;374:311-22.

https://doi.org/10.1056/NEJMoa1513257

PMid:26639348 PMCid:PMC7107002

30. Diniz MG, Gomes CC, de Castro WH, Guimarães AL, De Paula AM, Amm H, et al. miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors. Cell Oncol. 2012;35:285-91.

https://doi.org/10.1007/s13402-012-0087-3

PMid:22684875