Peña-Cardelles JF, Markovic J, Akhondi S, Pedrinaci I, Lanis A, Gallucci GO. Inferior alveolar nerve damage related to dental implant placement. A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2025 Jul 1;30 (4):e578-89.


doi:10.4317/medoral.27125

https://dx.doi.org/doi:10.4317/medoral.27125


1. Elani HW, Starr JR, Da Silva JD, Gallucci GO. Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. J Dent Res. 2018;97:1424-30.

https://doi.org/10.1177/0022034518792567

PMid:30075090 PMCid:PMC6854267

2. Jacobs R, Quirynen M, Bornstein MM. Neurovascular disturbances after implant surgery. Periodontol 2000. 2014;66:188-202.

https://doi.org/10.1111/prd.12050

PMid:25123768 

3. Juodzbalys G, Wang HL, Sabalys G. Injury of the Inferior Alveolar Nerve during Implant Placement: a Literature Review. J Oral Maxillofac Res. 2011;1:e1.

https://doi.org/10.5037/jomr.2011.2101

PMid:24421983 PMCid:PMC3886063

4. Seddon HJ. A Classification of Nerve Injuries. Br Med J. 1942;29:237-9.

https://doi.org/10.1136/bmj.2.4260.237

PMid:20784403 PMCid:PMC2164137

5. Froum SJ, Bergamini M, Reis N, Wang W, Leung M, Kaufman Z, et al. A New Concept of Safety Distance to Place Implants in the Area of the Inferior Alveolar Canal to Avoid Neurosensory Disturbance. Int J Periodontics Restorative Dent. 2021;41:e139-46.

https://doi.org/10.11607/prd.5626

PMid:34328468 

6. Lin CS, Wu SY, Huang HY, Lai YL. Systematic Review and Meta-Analysis on Incidence of Altered Sensation of Mandibular Implant Surgery. PLoS One. 2016;21:e0154082.

https://doi.org/10.1371/journal.pone.0154082

PMid:27100832 PMCid:PMC4839635

7. Misch CE, Crawford EA. Predictable mandibular nerve location--a clinical zone of safety. Int J Oral Implantol. 1990;7:37-40.

PMid:2081051

8. Bartling R, Freeman K, Kraut RA. The incidence of altered sensation of the mental nerve after mandibular implant placement. J Oral Maxillofac Surg. 1999;57:1408-12.

https://doi.org/10.1016/S0278-2391(99)90720-6

PMid:10596660 

9. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. Phys Ther. 2009;89:873-80.

https://doi.org/10.1093/ptj/89.9.873

PMid:19723669 

10. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25:603-5.

https://doi.org/10.1007/s10654-010-9491-z

PMid:20652370 

11. Hartmann A, Welte-Jzyk C, Seiler M, Daubländer M. Neurophysiological changes associated with implant placement. Clin Oral Implants Res. 2017;28:576-81.

https://doi.org/10.1111/clr.12837

PMid:27002225 

12. Kim HK, Kim ME. Quantitative and qualitative sensory testing results are associated with numbness rather than neuropathic pain in patients with post-implant trigeminal neuropathy: a cross-sectional pilot study. Somatosens Mot Res. 2019;36:202-11.

https://doi.org/10.1080/08990220.2019.1645000

PMid:31366273 

13. Kütük N, Gönen ZB, Yaşar MT, Demirbaş AE, Alkan A. Reliability of panoramic radiography in determination of neurosensory disturbances related to dental implant placement in posterior mandible. Implant Dent. 2014;23:648-52.

https://doi.org/10.1097/ID.0000000000000160

PMid:25365650 

14. Pääsky E, Suomalainen A, Ventä I. Are women more susceptible than men to iatrogenic inferior alveolar nerve injury in dental implant surgery? Int J Oral Maxillofac Surg. 2022;51:251-6.

https://doi.org/10.1016/j.ijom.2021.05.008

PMid:34074573 

15. Scarano A, Sinjari B, Murmura G, Lorusso F. Neurosensory Disturbance of the Inferior Alveolar Nerve After 3025 Implant Placements. Implant Dent. 2017;26:735-43.

https://doi.org/10.1097/ID.0000000000000651

PMid:28906271 

16. Politis C, Agbaje J, Van Hevele J, Nicolielo L, De Laat A, Lambrichts I, et al. Report of Neuropathic Pain After Dental Implant Placement: A Case Series. Int J Oral Maxillofac Implants. 2017;32:439-44.

https://doi.org/10.11607/jomi.5241

PMid:28291863 

17. Vázquez-Delgado E, Viaplana-Gutiérrez M, Figueiredo R, Renton T, Gay-Escoda C, Valmaseda-Castellón E. Prevalence of neuropathic pain and sensory alterations after dental implant placement in a university-based oral surgery department: A retrospective cohort study. Gerodontology. 2018;35:117-22.

https://doi.org/10.1111/ger.12326

PMid:29460459 

18. Klazen Y, Van der Cruyssen F, Vranckx M, Van Vlierberghe M, Politis C, Renton T, et al. Iatrogenic trigeminal post-traumatic neuropathy: a retrospective two-year cohort study. Int J Oral Maxillofac Surg. 2018;47:789-93.

https://doi.org/10.1016/j.ijom.2018.02.004

PMid:29523381 

19. Chaar MS, Naguib AA, Abd Alsamad AM, Ahmed DF, Abdel Nabi N, Kern M. Vascular and neurosensory evaluation in relation to lingual canal anatomy after mandibular midline implant installation in edentulous patients. Clin Oral Investig. 2022;26:3311-23.

https://doi.org/10.1007/s00784-021-04312-w

PMid:34985576 PMCid:PMC8898232

20. Froum SJ, Bergamini M, Reis N, Wang W, Leung M, Kaufman Z. et al. A New Concept of Safety Distance to Place Implants in the Area of the Inferior Alveolar Canal to Avoid Neurosensory Disturbance. Int J Periodontics Restorative Dent. 2021;41:e139-46.

https://doi.org/10.11607/prd.5626

PMid:34328468 

21. Karabit ZZ, Al Kattan FZ. Is there any relationship between the inferior alveolar nerve injuries caused by implant surgery and the qualification of the dentist? New Armen Med J. 2018;12:29-35.

PMid:

22. Juodzbalys G, Wang HL, Sabalys G, Sidlauskas A, Galindo-Moreno P. Inferior alveolar nerve injury associated with implant surgery. Clin Oral Implants Res. 2013;24:183-90.

https://doi.org/10.1111/j.1600-0501.2011.02314.x

PMid:22092662 

23. Givol N, Peleg O, Yarom N, Blinder D, Lazarovici TS. Inferior alveolar neurosensory deficiency associated with placement of dental implants. J Periodontol. 2013;84:495-501.

https://doi.org/10.1902/jop.2012.110599

PMid:22813346 

24. Agbaje JO, Van de Casteele E, Hiel M, Verbaanderd C, Lambrichts I, Politis C. Neuropathy of Trigeminal Nerve Branches After Oral and Maxillofacial Treatment. J Maxillofac Oral Surg. 2016;15:321-7.

https://doi.org/10.1007/s12663-015-0843-9

PMid:27752201 PMCid:PMC5048319

25. Bornstein MM, Scarfe WC, Vaughn VM, Jacobs R. Cone beam computed tomography in implant dentistry: a systematic review focusing on guidelines, indications, and radiation dose risks. Int J Oral Maxillofac Implants. 2014;29:55-77.

https://doi.org/10.11607/jomi.2014suppl.g1.4

PMid:24660190 

26. Ludlow JB, Ivanovic M. Comparative dosimetry of dental CBCT devices and 64-slice CT for oral and maxillofacial radiology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:106-14.

https://doi.org/10.1016/j.tripleo.2008.03.018

PMid:18504152 

27. Schulze R, Heil U, Gross D, Bruellmann DD, Dranischnikow E, Schwanecke U, et al. Artefacts in CBCT: a review. Dentomaxillofac Radiol. 2011;40:265-73.

https://doi.org/10.1259/dmfr/30642039

PMid:21697151 PMCid:PMC3520262

28. Pauwels R, Araki K, Siewerdsen JH, Thongvigitmanee SS. Technical aspects of dental CBCT: state of the art. Dentomaxillofac Radiol. 2015;44:20140224.

https://doi.org/10.1259/dmfr.20140224

PMid:25263643 PMCid:PMC4277439

29. Walton JN. Altered sensation associated with implants in the anterior mandible: a prospective study. J Prosthet Dent. 2000;83:443-9.

https://doi.org/10.1016/S0022-3913(00)70039-4

PMid:10756294 

30. Pinsky HM, Dyda S, Pinsky RW, Misch KA, Sarment DP. Accuracy of three-dimensional measurements using cone-beam CT. Dentomaxillofac Radiol. 2006;35:410-6.

https://doi.org/10.1259/dmfr/20987648

PMid:17082331 

31. Kiyak HA, Beach BH, Worthington P, Taylor T, Bolender C, Evans J. Psychological impact of osseointegrated dental implants. Int J Oral Maxillofac Implants. 1990;5:61-9.

PMid:2202671

32. Al-Sabbagh M, Okeson JP, Bertoli E, Medynski DC, Khalaf MW. Persistent pain and neurosensory disturbance after dental implant surgery: prevention and treatment. Dent Clin North Am. 2015;59:143-56.

https://doi.org/10.1016/j.cden.2014.08.005

PMid:25434563 

33. Steinberg MJ, Kelly PD. Implant-related nerve injuries. Dent Clin North Am. 2015;59:357-73.

https://doi.org/10.1016/j.cden.2014.10.003

PMid:25835799 

34. Pedrinaci I, Sun TC, Sanz-Alonso M, Sanz-Esporrin J, Hamilton A, Gallucci GO. Implant survival in the anterior mandible: A retrospective cohort study. Clin Oral Implants Res. 2023;34:463-74.

https://doi.org/10.1111/clr.14052

PMid:36806171 

35. Poort LJ, van Neck JW, van der Wal KG. Sensory testing of inferior alveolar nerve injuries: a review of methods used in prospective studies. J Oral Maxillofac Surg. 2009;67:292-300.

https://doi.org/10.1016/j.joms.2008.06.076

PMid:19138602 

36. Yamauchi K, Takahashi T, Kaneuji T, Nogami S, Yamamoto N, Miyamoto I, et al. Risk factors for neurosensory disturbance after bilateral sagittal split osteotomy based on position of mandibular canal and morphology of mandibular angle. J Oral Maxillofac Surg. 2012;70:401-6.

https://doi.org/10.1016/j.joms.2011.01.040

PMid:21549489 

37. Khawaja N, Renton T. Case studies on implant removal influencing the resolution of inferior alveolar nerve injury. Br Dent J. 2009;11:365-70.

https://doi.org/10.1038/sj.bdj.2009.258

PMid:19357667