Gil J, Fonseca D, Fernández-Domínguez M, Fernández-Domínguez P, Akagi-Camacho S, Toledano-Serrabona J, Vegas-Bustamante E, Camps-Font O, Sánchez-Garcés MA, Aragoneses JM. Immunological and tissue reactions to titanium particles generated by the mechanical decontamination of dental implants: In vitro and in vivo study. Med Oral Patol Oral Cir Bucal. 2026 Jan 1;31 (1):e11-e18.

doi:10.4317/medoral.27171

https://dx.doi.org/doi:10.4317/medoral.27171


1. Tomasi C, Regidor E, Ortiz Vigón A, Derks J. Efficacy of reconstructive surgical therapy at peri implantitis related bone defects: A systematic review and meta analysis. J Clin Periodontol. 2019;46(Suppl 21):340-356
https://doi.org/10.1111/jcpe.13070
PMid:30667523

2. Kotsakis GA, Lan C, Barbosa J, Lill K, Chen R, Rudney J, et al. Antimicrobial agents used in the treatment of peri implantitis alter the physicochemistry and cytocompatibility of titanium surfaces. J Periodontol. 2016;87(7):809-819
https://doi.org/10.1902/jop.2016.150684
PMid:26923474

3. Toledano Serrabona J, Gil FJ, Camps Font O, Valmaseda Castellón E, Gay Escoda C, Sánchez Garcés MÁ. Physicochemical and biological characterization of Ti6Al4V particles obtained by implantoplasty: An in vitro study. Part I. Mater (Basel). 2021;14(21):6507
https://doi.org/10.3390/ma14216507
PMid:34772034 PMCid:PMC8585232

4. Wu X, Cai C, Gil J, Jantz E, Al Sakka Y, Padial Molina M, et al. Characteristics of particles and debris released after implantoplasty: A comparative study. Mater (Basel). 2022;15(2):602
https://doi.org/10.3390/ma15020602
PMid:35057319 PMCid:PMC8779414

5. Kotsakis GA, Xie L, Siddiqui DA, Daubert D, Graham DJ, Gil FJ. Dynamic assessment of titanium surface oxides following mechanical damage reveals only partial passivation under inflammatory conditions. NPJ Mater Degrad. 2024;8(1):98
https://doi.org/10.1038/s41529-024-00514-1
PMid:39583186 PMCid:PMC11578884

6. Callejas JA, Gil J, Brizuela A, Pérez RA, Bosch BM. Effect of the size of titanium particles released from dental implants on immunological response. Int J Mol Sci. 2022;23(13):7333
https://doi.org/10.3390/ijms23137333
PMid:35806339 PMCid:PMC9266706

7. de Tapia B, Valles C, Ribeiro Amaral T, Mor C, Herrera D, Sanz M, et al. The adjunctive effect of a titanium brush in implant surface decontamination at peri implantitis surgical regenerative interventions: A randomized controlled clinical trial. J Clin Periodontol. 2019;46(5):586-596
https://doi.org/10.1111/jcpe.13095
PMid:30825341

8. Francis S, Iaculli F, Perrotti V, Piattelli A, Quaranta A. Titanium surface decontamination: A systematic review of in vitro comparative studies. Int J Oral Maxillofac Implants. 2022;37(1):76-84
https://doi.org/10.11607/jomi.8969
PMid:35235623

9. Monje A, Schwarz F. Principles of combined surgical therapy for the management of peri implantitis. Clin Adv Periodontics. 2022;12(1):57-63
https://doi.org/10.1002/cap.10186
PMid:34569711

10. Costa Berenguer X, García García M, Sánchez Torres A, Sanz Alonso M, Figueiredo R, Valmaseda Castellón E. Effect of implantoplasty on fracture resistance and surface roughness of standard diameter dental implants. Clin Oral Implants Res. 2018;29(1):46-54
https://doi.org/10.1111/clr.13037
PMid:28736922

11. Toledano Serrabona J, Bosch BM, Díez Tercero L, Gil FJ, Camps Font O, Valmaseda Castellón E, et al. Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants. Sci Rep. 2022;12(1):15790
https://doi.org/10.1038/s41598-022-20100-2
PMid:36138061 PMCid:PMC9500064

12. Barrak FN, Li S, Muntane AM, Jones JR. Particle release from implantoplasty of dental implants and impact on cells. Int J Implant Dent. 2020;6(1):50
https://doi.org/10.1186/s40729-020-00247-1
PMid:32918144 PMCid:PMC7486360

13. Zhou Z, Shi Q, Wang J, Chen X, Hao Y, Zhang Y, et al. The unfavorable role of titanium particles released from dental implants. Nanotheranostics. 2021;5(3):321-332
https://doi.org/10.7150/ntno.56401
PMid:33732603 PMCid:PMC7961127

14. Pettersson M, Pettersson J, Johansson A, Molin Thorén M. Titanium release in peri implantitis. J Oral Rehabil. 2019;46(2):179-188
https://doi.org/10.1111/joor.12735
PMid:30325523

15. Olmedo DG, Paparella ML, Spielberg M, Brandizzi D, Guglielmotti MB, Cabrini RL. Oral mucosa tissue response to titanium cover screws. J Periodontol. 2012;83(8):973-980
https://doi.org/10.1902/jop.2011.110392
PMid:22141355

16. Gosau M, Hahnel S, Schwarz F, Gerlach T, Reichert TE, Bürgers R. Effect of six different peri implantitis disinfection methods on in vivo human oral biofilm. Clin Oral Implants Res. 2010;21(8):866-872
https://doi.org/10.1111/j.1600-0501.2009.01908.x
PMid:20666798

17. Ratka C, Weigl P, Henrich D, Koch F, Schlee M, Zipprich H. The effect of in vitro electrolytic cleaning on biofilm contaminated implant surfaces. J Clin Med. 2019;8(9):1397
https://doi.org/10.3390/jcm8091397
PMid:31500093 PMCid:PMC6780638

18. Eger M, Hiram Bab S, Liron T, Sterer N, Carmi Y, Kohavi D, Gabet Y. Mechanism and prevention of titanium particle induced inflammation and osteolysis. Front Immunol. 2018;9:2963
https://doi.org/10.3389/fimmu.2018.02963
PMid:30619321 PMCid:PMC6305459

19. Toma S, Lasserre J, Brecx MC, Nyssen Behets C. In vitro evaluation of peri implantitis treatment modalities on Saos 2 osteoblasts. Clin Oral Implants Res. 2016;27(9):1085-1092
https://doi.org/10.1111/clr.12686
PMid:26361088

20. Eger M, Sterer N, Liron T, Kohavi D, Gabet Y. Scaling of titanium implants entrains inflammation induced osteolysis. Sci Rep. 2017;7:39612
https://doi.org/10.1038/srep39612
PMid:28059080 PMCid:PMC5216395

21. Pettersson M, Kelk P, Belibasakis GN, Bylund D, Molin Thorén M, Johansson A. Titanium ions form particles that activate and execute interleukin 1β release from lipopolysaccharide primed macrophages. J Periodontal Res. 2017;52(1):21-32
https://doi.org/10.1111/jre.12364
PMid:26987886 PMCid:PMC5297875

22. Makita N, Suzuki M, Asami S, Takahata R, Kohzaki D, Kobayashi S, et al. Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells. Gene. 2008;413(1-2):8-17
https://doi.org/10.1016/j.gene.2007.12.025
PMid:18321663

23. Mikami R, Mizutani K, Nagai S, Pavlic V, Iwata T, Aoki A. A novel minimally invasive approach for metal tattoo removal with Er:YAG laser. J Esthet Restor Dent. 2021;33(4):550-559
https://doi.org/10.1111/jerd.12721
PMid:33565693

24. Taylor TD, Klotz MW, Lawton RA. Titanium tattooing associated with zirconia implant abutments: A clinical report of two cases. Int J Oral Maxillofac Implants. 2014;29(4):958-960
https://doi.org/10.11607/jomi.3700
PMid:24914813

25. Toledano Serrabona J, Sánchez Garcés MÁ, Gay Escoda C, Valmaseda Castellón E, Camps Font O, Verdeguer P, et al. Mechanical properties and corrosion behavior of Ti6Al4V particles obtained by implantoplasty: An in vitro study. Part II. Mater (Basel). 2021;14(21):6519
https://doi.org/10.3390/ma14216519
PMid:34772042 PMCid:PMC8585323

26. Toledano Serrabona J, Camps Font O, de Moraes DP, Corte Rodríguez M, Montes Bayón M, Valmaseda Castellón E, et al. Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats. J Periodontol. 2023;94(1):119-129
https://doi.org/10.1002/JPER.22-0091
PMid:35678251 PMCid:PMC10087269

27. Lozano P, Peña M, Herrero Climent M, Rios Santos JV, Rios Carrasco B, Brizuela A, et al. Corrosion behavior of titanium dental implants with implantoplasty. Mater (Basel). 2022;15(4):1563
https://doi.org/10.3390/ma15041563
PMid:35208101 PMCid:PMC8875252