Tejedo JR, Jara RA, Caceres LZ, Vergara-Buenaventura A, Muniz FW, Faveri M, et al. De-epithelialized free gingival graft versus subepithelial connective tissue graft in the treatment of gingival recession: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2025 Sep 1;30 (5):e690-9.
doi:10.4317/medoral.27184
https://dx.doi.org/doi:10.4317/medoral.27184
1. Cortellini P, Bissada NF. Mucogingival conditions in the natural dentition: Narrative review, case definitions, and diagnostic considerations. J Periodontol. 2018;89:S204-213. |
PMid:29926948 |
2. Nisha S, Shashikumar P. Periosteal pedicle graft with coronally advanced flap and its comparison with modified coronally advanced flap in the treatment of multiple adjacent gingival recessions-a randomized clinical trial. J Oral Biol Craniofac Res. 2021;11:99-106. |
PMid:33532194 PMCid:PMC7829268 |
3. Imber JC, Kasaj A. Treatment of Gingival Recession: When and How?. Int Dent J. 2021;7:178-87. |
PMid:34024328 PMCid:PMC9275303 |
4. Salaria S, Khunger A, Yadav V, Sharma G. Periodontal microsurgical-assisted pouch and tunnel approach in combination with subepithelial connective tissue graft for the management of class IIB and IIC multiple adjacent gingival recessions in mandibular anterior segment. Contemp Clin Dent. 2018;9:667-9. |
PMid:31772484 PMCid:PMC6868632 |
5. Cong Z, Liu Y, Zhao J. Treatment of multiple adjacent gingival recessions with an acellular dermal matrix or a connective tissue graft: a Meta-analysis. Hua Xi Kou Qiang Yi Xue Za Zhi / West China Journal of Stomatology. 2022;40:690-7. |
PMid:36416322 |
6. Neves FL da S, Augusto Silveira C, Mathias‐Santamaria IF, Miguel MMV, Ferraz LFF, Casarin RCV, et al. Randomized clinical trial evaluating single maxillary gingival recession treatment with connective tissue graft and tunnel or trapezoidal flap: 2‐year follow‐up. J Periodontol. 2020;9:1018-26. |
PMid:31867724 |
7. Molnár B, Aroca S, Dobos A, Orbán K, Szabó J, Windisch P, et al. Treatment of multiple adjacent RT 1 gingival recessions with the modified coronally advanced tunnel (MCAT) technique and a collagen matrix or palatal connective tissue graft: 9-year results of a split-mouth randomized clinical trial. Clin Oral Investig. 2022;26:7135-42. |
PMid:35994126 PMCid:PMC9708797 |
8. Bakhishov H, Isler SC, Bozyel B, Yıldırım B, Tekindal MA, Ozdemir B. De‐epithelialized gingival graft versus subepithelial connective tissue graft in the treatment of multiple adjacent gingival recessions using the tunnel technique: 1‐year results of a randomized clinical trial. J Clin Periodontol. 2021;48:970-83. |
PMid:33751615 |
9. Aroca S, Barbieri A, Clementini M, Renouard F, de Sanctis M. Treatment of class III multiple gingival recessions: Prognostic factors for achieving a complete root coverage. J Clin Periodontol. 2018;45:861-8. |
PMid:29757468 |
10. Tavelli L, Barootchi S, Nguyen TVN, Tattan M, Ravidà A, Wang H. Efficacy of tunnel technique in the treatment of localized and multiple gingival recessions: A systematic review and meta‐analysis. J Periodontol. 2018;89:1075-90. |
PMid:29761502 |
11. Garces‐McIntyre T, Carbonell JM, Vallcorba L, Santos A, Valles C, Nart J. Coronal advanced flap in combination with a connective tissue graft. Is the thickness of the flap a predictor for root coverage? A prospective clinical study. J Clin Periodontol. 2017;44:933-40. |
PMid:28667741 |
12. Tavelli L, Barootchi S, Di Gianfilippo R, Modarressi M, Cairo F, Rasperini G, et al. Acellular dermal matrix and coronally advanced flap or tunnel technique in the treatment of multiple adjacent gingival recessions. A 12‐year follow‐up from a randomized clinical trial. J Clin Periodontol. 2019;46:937-48. |
PMid:31242333 |
13. Bosco AF, Bosco JMD. An alternative technique to the harvesting of a connective tissue graft from a thin palate: enhanced wound healing. Int J Periodontics Restorative Dent. 2007;27:133-9. |
PMid:17514885 |
14. Zucchelli G, Mele M, Stefanini M, Mazzotti C, Marzadori M, Montebugnoli L, et al. Patient morbidity and root coverage outcome after subepithelial connective tissue and de‐epithelialized grafts: a comparative randomized‐controlled clinical trial. J Clin Periodontol. 2010;37:728-38. |
PMid:20590963 |
15. Tavelli L. Comparison between Subepithelial Connective Tissue Graft and De-epithelialized Gingival Graft: A systematic review and a meta-analysis. J Int Acad Periodontol. 2019;21:82-96. |
PMid:10635174 |
16. Xue F, Zhang R, Cai Y, Zhang Y, Kang N, Luan Q. Three‐dimensional quantitative measurement of buccal augmented tissue with modified coronally advanced tunnel technique and de‐epithelialized gingival graft: a prospective case series. BMC Oral Health. 2021;21:157. |
PMid:33765988 PMCid:PMC7992864 |
17. Mashaly M, Ghallab N, Elbattawy W, Elarab A. Soft tissue augmentation using de-epithelialized free gingival graft compared to single-line incision subepithelial connective tissue graft in the management of miller class I and II gingival recession: A randomized controlled clinical trial. Contemp Clin Dent. 2022;13(3):227-35. |
PMid:36213850 PMCid:PMC9533386 |
18. Meza-Mauricio J, Mourão ERST, Oliveira Marinho K, Vergara-Buenaventura A, Mendoza-Azpur G, Muniz FWMG, et al. Effect of collagen sponge and flowable resin composite on pain management after free gingival graft harvesting: A randomized controlled clinical trial. Eur J Oral Sci. 2023;131(3): e12935. |
PMid:37169726 |
19. Azar E, Rojas M, Patricia M, Carranza N. Histologic and Histomorphometric Analyses of De-epithelialized Free Gingival Graft in Humans. Int J Periodontics Restorative Dent. 2019;39:221-6. |
PMid:30794258 |
20. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. |
PMid:33782057 PMCid:PMC8005924 |
21. Riley RD, Moons KGM, Snell KIE, Ensor J, Hooft L, Altman DG, et al. A guide to systematic review and meta-analysis of prognostic factor studies. BMJ. 2019;364:k4597. |
PMid:30700442 |
22. Schardt C, Adams MB, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007;7:16. |
PMid:17573961 PMCid:PMC1904193 |
23. Miller PD. A classification of marginal tissue recession. Int J Periodontics Restorative Dent. 1985;5:8-13. |
PMid:3858267 |
24. Cairo F, Nieri M, Cincinelli S, Mervelt J, Pagliaro U. The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: an explorative and reliability study. J Clin Periodontol. 2011;38:661-6. |
PMid:21507033 |
25. Greenhalgh T, Peacock R. Effectiveness and efficiency of search methods in systematic reviews of complex evidence: audit of primary sources. BMJ. 2005;331:1064-5. |
PMid:16230312 PMCid:PMC1283190 |
26. De Raadt A, Warrens MJ, Bosker RJ, Kiers HAL. Kappa Coefficients for Missing Data. Educ Psychol Meas. 2019;79:558-76. |
PMid:31105323 PMCid:PMC6506991 |
27. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. |
PMid:31462531 |
28. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64:383-94. |
PMid:21195583 |
29. Guyatt GH, Thorlund K, Oxman AD, Walter SD, Patrick D, Furukawa TA, et al. GRADE guidelines: 13. Preparing Summary of Findings tables and evidence profiles-continuous outcomes. J Clin Epidemiol. 2013;66:173-83. |
PMid:23116689 |
30. Zucchelli G, Mounssif I, Mazzotti C, Montebugnoli L, Sangiorgi M, Mele M, et al. Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial. J Clin Periodontol. 2014;41:708-16. |
PMid:24708394 |
31. Jenabian N, Bahabadi MY, Bijani A, Rad MR. Gingival Unit Graft Versus Free Gingival Graft for Treatment of Gingival Recession: A Randomized Controlled Clinical Trial. J Dent (Tehran). 2016;13:184-92. |
PMid:28392815 |
32. Pandit N, Khasa M, Gugnani S, Malik R, Bali D. Comparison of two techniques of harvesting connective tissue and its effects on healing pattern at palate and recession coverage at recipient site. Contemp Clin Dent. 2016;7:3-10. |
PMid:27041892 PMCid:PMC4792051 |
33. Ho FC. A modified combined approach to harvest connective tissue grafts with high quality, less morbidity, and faster healing. Int J Esthet Dent. 2020;15:56-67. |
PMid:31994536 |
34. Sriwil M, Fakher M, Hasan K, Kasem T, Shwaiki T, Wassouf G. Comparison of Free Gingival Graft and Gingival Unit Graft for Treatment of Gingival Recession: A Randomized Controlled Trial. Int J Periodontics Restorative Dent. 2020;40:e103-10. |
PMid:32233187 |
35. Ripoll S, Fernández de Velasco-Tarilonte Á, Bullón B, Ríos-Carrasco B, Fernández-Palacín A. Complications in the Use of Deepithelialized Free Gingival Graft vs. Connective Tissue Graft: A One-Year Randomized Clinical Trial. Int J Environ Res Public Health. 2021;18:4504. |
PMid:33922745 PMCid:PMC8123082 |
36. Naziker Y, Ertugrul AS. Aesthetic evaluation of free gingival graft applied by partial de-epithelialization and free gingival graft applied by conventional method: a randomized controlled clinical study. Clin Oral Investig. 2023;27:4029-38. |
PMid:37118334 |
37. Zangrando MSR, Eustachio RR, de Rezende MLR, Sant'ana ACP, Damante CA, Greghi SLA. Clinical and patient‐centered outcomes using two types of subepithelial connective tissue grafts: A split‐mouth randomized clinical trial. J Periodontol. 2021;92:814-22. |
PMid:32997816 |
38. Beymouri A, Yaghobee S, Khorsand A, Safi Y. Comparison of morbidity at the donor site and clinical efficacy at the recipient site between two different connective tissue graft harvesting techniques from the palate: A randomized clinical trial. J Adv Periodontol Implant Dent. 2023;15:108-16. |
PMid:38357340 PMCid:PMC10862051 |
39. Chambrone L, Botelho J, Machado V, Mascarenhas P, Mendes JJ, Avila‐Ortiz G. Does the subepithelial connective tissue graft in conjunction with a coronally advanced flap remain as the gold standard therapy for the treatment of single gingival recession defects? A systematic review and network meta‐analysis. J Periodontol. 2022;93:1336-52. |
PMid:35451068 |