Polat-Akmansoy B, Aksoy B, Şişman-Kitapçı N, Akmansoy ŞC, Çandereli ZÖ, Sarı FB, et al. Cluster and correspondence analyses for oral ulcer activity related factors in Behçet’s syndrome. Med Oral Patol Oral Cir Bucal. 2025 Sep 1;30 (5):e766-73.


doi:10.4317/medoral.27242

https://dx.doi.org/doi:10.4317/medoral.27242


1. Mumcu G, Fortune F. Oral Health and Its Aetiological Role in Behçet's Disease. Front Med (Lausanne). 2021;8:613419.

https://doi.org/10.3389/fmed.2021.613419

PMid:34095159 PMCid:PMC8172597

2. Mumcu G, Direskeneli H. Triggering agents and microbiome as environmental factors on Behcet's syndrome. Intern Emerg Med. 2019;14:653-60.

https://doi.org/10.1007/s11739-018-2000-1

PMid:30523495 

3. Mumcu G, Karacayli U, Yay M, Aksoy A, Tas MN, Armagan B, et al. Oral ulcer activity assessment with the composite index according to different treatment modalities in Behcet's syndrome: a multicentre study. Clin Exp Rheumatol. 2019;37:98-104.

PMID: 31856935

4. Senusi A, Kang A, Buchanan JAG, Adesanya A, Aloraini G, Stanford M, et al. New mouthwash: an efficacious intervention for oral ulceration associated with Behcet's disease. Br J Oral Maxillofac Surg. 2020;58:1034-9.

https://doi.org/10.1016/j.bjoms.2020.07.027

PMid:32819746 

5. Hamuryudan V, Hatemi G, Sut N, Ugurlu S, Yurdakul S, Yazici H. Frequent oral ulceration during early disease may predict a severe disease course in males with Behcet's syndrome. Clin Exp Rheumatol. 2012;30:32-4.

PMID: 22935508

6. Alibaz-Oner F, Mumcu G, Kubilay Z, Ozen G, Celik G, Karadeniz A, et al. Unmet need in Behcet's disease: most patients in routine follow-up continue to have oral ulcers. Clin Rheumatol. 2014;33:1773-6.

https://doi.org/10.1007/s10067-014-2585-3

PMid:24737283 

7. Karacayli U, Mumcu G, Simsek I, Pay S, Kose O, Erdem H, et al. The close association between dental and periodontal treatments and oral ulcer course in behcet's disease: A prospective clinical study. J Oral Pathol Med. 2009;38:410-5.

https://doi.org/10.1111/j.1600-0714.2009.00765.x

PMid:19320802 

8. Yazici Y, Hatemi G, Bodaghi B, Cheon JH, Suzuki N, Ambrose N, et al. Behçet syndrome. Nat Rev Dis Primers. 2021;7:67.

https://doi.org/10.1038/s41572-021-00301-1

PMid:34531393 

9. Lopalco G, Morrone M, Venerito V, Cantarini L, Emmi G, Espinosa G, et al. Exploring relief for Behcet's disease refractory oral ulcers: a comparison of TNF inhibitors versus apremilast. Rheumatology (Oxford). 2025;64:1302-8.

https://doi.org/10.1093/rheumatology/keae274

PMid:38814802 

10. Candereli ZO, Arslan T, Ozdamar O, Yay M, Karacayli U, Sisman-Kitapci N, et al. Does decision tree analysis predict oral ulcer activity-related factors in patients with Behcet's syndrome? Clin Exp Rheumatol. 2023;41:2078-86.

https://doi.org/10.55563/clinexprheumatol/5kr2b1

PMid:37902270 

11. Fragoulis GE, Bertsias G, Bodaghi B, Gul A, van Laar J, Mumcu G, et al. Treat to target in Behcet's disease: Should we follow the paradigm of other systemic rheumatic diseases? Clin Immunol. 2023;246:109186.

https://doi.org/10.1016/j.clim.2022.109186

PMid:36410686 

12. Zhao L, Fang J, Ji Y, Zhang Y, Zhou X, Yin J, Zhang M, Bao W. K-means cluster analysis of characteristic patterns of allergen in different ages: Real life study. Clin Transl Allergy. 2023;13:e12281.

https://doi.org/10.1002/clt2.12281

PMid:37488740 PMCid:PMC10326892

13. Hu D, She CH, Bao HF, Zou J, Cai JF, Ye JF, et al. Clinical heterogeneity and five phenotypes identified in pediatric Behcet's syndrome: a cohort study from Shanghai Behcet's syndrome database. World J Pediatr. 2024;20:801-8.

https://doi.org/10.1007/s12519-023-00785-9

PMid:38315355 PMCid:PMC11402839

14. Ilgen U. Cluster analysis as a clinical and research tool in Behcet's syndrome. Curr Opin Rheumatol. 2024;36:3-8.

https://doi.org/10.1097/BOR.0000000000000980

PMid:37729051 

15. Kilic G, Koruklu KF, Kumcu MG, Cakir E, Karkucak M, Kilic E. Gender disparities in Behcet's syndrome: identifying distinct phenotypes through cluster analysis. Immunol Res. 2024;72:975-81.

https://doi.org/10.1007/s12026-024-09498-1

PMid:38806970 PMCid:PMC11564306

16. Marinello D, Palla I, Lorenzoni V, Andreozzi G, Pirri S, Ticciati S, et al. Exploring disease perception in Behcet's syndrome: combining a quantitative and a qualitative study based on a narrative medicine approach. Orphanet J Rare Dis. 2023;18:58.

https://doi.org/10.1186/s13023-023-02668-8

PMid:36934245 PMCid:PMC10024433

17. Soejima Y, Kirino Y, Takeno M, Kurosawa M, Takeuchi M, Yoshimi R, et al. Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behcet's disease in Japan. Arthritis Res Ther. 2021;23:49.

https://doi.org/10.1186/s13075-020-02406-6

PMid:33522943 PMCid:PMC7851921

18. Žlahtič B, Kokol P, Blažun Vošner H, Završnik J. The role of correspondence analysis in medical research. Front Public Health. 2024;12:1362699.

https://doi.org/10.3389/fpubh.2024.1362699

PMid:38584915 PMCid:PMC10995278

19. Tascilar K, Melikoglu M, Ugurlu S, Sut N, Caglar E, Yazici H. Vascular involvement in Behçet's syndrome: a retrospective analysis of associations and the time course. Rheumatology (Oxford). 2014;53:2018-22.

https://doi.org/10.1093/rheumatology/keu233

PMid:24907156 

20. Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet. 1990;335:1078-80.

https://doi.org/10.1016/0140-6736(90)92643-V

PMid:1970380

21. Krause I, Mader R, Sulkes J, Paul M, Uziel Y, Adawi M, et al. Behcet's disease in Israel: the influence of ethnic origin on disease expression and severity. J Rheumatol. 2001;28:1033-6.

PMid:11361184

22. Mumcu G, Sur H, Inanc N, Karacayli U, Cimilli H, Sisman N, et al. A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis. J Oral Pathol Med. 2009;38:785-91.

https://doi.org/10.1111/j.1600-0714.2009.00803.x

PMid:19614861 

23. Leccese P, Ozguler Y, Christensen R, Esatoglu SN, Bang D, Bodaghi B, et al., editors. Management of skin, mucosa and joint involvement of Behcet's syndrome: a systematic review for update of the EULAR recommendations for the management of Behcet's syndrome. Semin Arthritis Rheum. 2019;48:752-62.

https://doi.org/10.1016/j.semarthrit.2018.05.008

PMid:29954598 

24. van der Houwen TB, van Hagen PM, van Laar JAM. Immunopathogenesis of Behcet's disease and treatment modalities. Semin Arthritis Rheum. 2022;52:151956.

https://doi.org/10.1016/j.semarthrit.2022.151956

PMid:35038644 

25. Bettiol A, Hatemi G, Vannozzi L, Barilaro A, Prisco D, Emmi G. Treating the Different Phenotypes of Behcet's Syndrome. Front Immunol. 2019;10:2830.

https://doi.org/10.3389/fimmu.2019.02830

PMid:31921115 PMCid:PMC6915087

26. Barbosa HC, de Queiroz Oliveira JA, da Costa JM, de Melo Santos RP, Miranda LG, de Carvalho Torres H, et al. Empowerment-oriented strategies to identify behavior change in patients with chronic diseases: an integrative review of the literature. Patient Educ Couns. 2021;104:689-702.

https://doi.org/10.1016/j.pec.2021.01.011

PMid:33478854 

27. Jo YG, Ortiz-Fernandez L, Coit P, Yilmaz V, Yentür SP, Alibaz-Oner F, et al. Sex-specific analysis in Behcet's disease reveals higher genetic risk in male patients. J Autoimmun. 2022;132:102882.

https://doi.org/10.1016/j.jaut.2022.102882

PMid:35987173 PMCid:PMC10614427

28. Marinello D, Di Cianni F, Del Bianco A, Mattioli I, Sota J, Cantarini L, et al. Empowering Patients in the Therapeutic Decision-Making Process: A Glance Into Behcet's Syndrome. Front Med (Lausanne). 2021;8:769870.

https://doi.org/10.3389/fmed.2021.769870

PMid:34966756 PMCid:PMC8710680