Mesquita CM, Diniz AC, Sakamoto SP, Vieira WA, Brito-Junior RB, Costa MD, et al. The effect of dexmedetomidine on perioperative events of orthognathic surgery: a systematic review of randomized controlled trials. Med Oral Patol Oral Cir Bucal. 2025 Nov 1;30 (6):e798-813.

  

doi:10.4317/medoral.27260

https://dx.doi.org/doi:10.4317/medoral.27260


1. Grillo R, Borba AM, Brozoski MA, da Silva YS, Samieirad S, Naclério-Homem M da G. Postoperative nausea and vomiting in orthognathic surgery: systematic review and meta-analysis. Oral Maxillofac Surg. 2024;28:1019-28.

https://doi.org/10.1007/s10006-024-01235-0

PMid:38509315 

2. Alyahya A, Aldubayan A, Swennen GRJ, Al-Moraissi E. Effectiveness of different protocols to reduce postoperative pain following orthognathic surgery: A systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2022;60:e1-10.

https://doi.org/10.1016/j.bjoms.2022.03.013

PMid:35690502 

3. Galdino-Santos L, da Luz-Silva G, Pires ALC, Cademartori MG, Pereira-Cenci T. Perioperative therapies to reduce edema after orthognathic surgery: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023;135:211-35.

https://doi.org/10.1016/j.oooo.2022.06.017

PMid:36307303 

4. Bär AK, Werkmeister R, Dort JC, Al-Nawas B. Perioperative care in orthognathic surgery - A systematic review and meta-analysis for enhanced recovery after surgery. J Craniomaxillofac Surg. 2024;52:1244-58.

https://doi.org/10.1016/j.jcms.2024.08.014

PMid:39183122 

5. Goswami M, Sangal A, Rahman B, Chawla S. Comparison of the safety and efficacy of dexmedetomidine with midazolam for the management of paediatric dental patients: A systematic review. J Indian Soc Pedod Prev Dent. 2021;39:233-9.

https://doi.org/10.4103/jisppd.jisppd_517_20

PMid:34810337 

6. Akavipat P, Sookplung P, Lekprasert V, Kasemsiri C, Lerdsirisophon S. Dexmedetomidine for awake craniotomy: Systematic review and meta-analysis. J Clin Neurosci. 2024;127:110765.

https://doi.org/10.1016/j.jocn.2024.110765

PMid:39079421 

7. Giffoni RB, Arguelles-Hernandez J, Dalmaschio MEP, Quintana PO, Lima AD. Dexmedetomidine supplementation for surgical field enhancement in endonasal surgery: a systematic review and meta-analysis. Rhinology. 2024;62:2-12.

PMID: 37814591

8. Janipour M, Bastaninejad S, Mohebbi A, Amali A, Owji SH, Jazi K, et al. Dexmedetomidine versus remifentanil in nasal surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2024;24:194.

https://doi.org/10.1186/s12871-024-02563-0

PMid:38816731 PMCid:PMC11138079

9. Pereira EMM, Viana P, da Silva RAM, Silott PF, Amaral S. Efficacy of Dexmedetomidine as an Adjuvant to Local Anesthetics in Peribulbar Block: A Meta-analysis With Trial-Sequential Analysis. Am J Ophthalmol. 2025;270:140-53.

https://doi.org/10.1016/j.ajo.2024.07.011

PMid:39033834 

10. Munhall CC, Warner BK, Nguyen SA, Guldan GJ, Meyer TA. Use of dexmedetomidine for controlled hypotension in middle ear surgery: A systematic review and meta-analysis. Am J Otolaryngol. 2023;44:103917.

https://doi.org/10.1016/j.amjoto.2023.103917

PMid:37163960 

11. Sakhariya SV, Waknis PP, Setiya S, Tidke SS. Effect of Induced Hypotensive Anesthesia and Normotensive Anesthesia on Intraoperative Blood Loss During Orthognathic Surgery: A Systematic Review. J Maxillofac Oral Surg. 2024;23:1127-37.

https://doi.org/10.1007/s12663-023-02034-y

PMid:39376768 

12. Yu DH, Shen X, Lai L, Chen YJ, Liu K, Shen QH. Application of Dexmedetomidine as an Opioid Substitute in Opioid-Free Anesthesia: A Systematic Review and Meta-analysis. Pain Physician. 2023;26:E635-49.

https://doi.org/10.36076/ppj.2023.26.E635

PMID: 37847917

13. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;349:g7647.

https://doi.org/10.1136/bmj.g7647

PMid:25555855 

14. Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160.

https://doi.org/10.1136/bmj.n160

PMid:33781993 PMCid:PMC8005925

15. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Systematic Reviews. 2016;5:210.

https://doi.org/10.1186/s13643-016-0384-4

PMid:27919275 PMCid:PMC5139140

16. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

https://doi.org/10.1136/bmj.l4898

PMid:31462531 

17. Balshem H, Helfand M, Schünemann HJ, Oxman AD, Kunz R, Brozek J, et al. GRADE guidelines: 3. Rating the quality of evidence. Journal of Clinical Epidemiology. 2011;64:401-6.

https://doi.org/10.1016/j.jclinepi.2010.07.015

PMid:21208779 

18. Murad MH, Mustafa RA, Schünemann HJ, Sultan S, Santesso N. Rating the certainty in evidence in the absence of a single estimate of effect. BMJ Evidence-Based Medicine. 2017;22:85-7.

https://doi.org/10.1136/ebmed-2017-110668

PMid:28320705 PMCid:PMC5502230

19. Farah GJ, de Moraes M, Filho LI, Pavan AJ, Camarini ET, Previdelli ITS, et al. Induced hypotension in orthognathic surgery: a comparative study of 2 pharmacological protocols. J Oral Maxillofac Surg. 2008;66:2261-9.

https://doi.org/10.1016/j.joms.2008.06.045

PMid:18940490 

20. Ham SY, Kim JE, Park C, Shin MJ, Shim YH. Dexmedetomidine does not reduce emergence agitation in adults following orthognathic surgery. Acta Anaesthesiol Scand. 2014;58:955-60.

https://doi.org/10.1111/aas.12379

PMid:25132201 

21. Rummasak D, Apipan B. Evaluation of the advantageous anesthetic properties of dexmedetomidine used as hypotensive agent compared with nitroglycerin in orthognathic surgery. J Oral Maxillofac Surg. 2014;72:2428-33.

https://doi.org/10.1016/j.joms.2014.07.026

PMid:25308408 

22. Shin S, Lee JW, Kim SH, Jung YS, Oh YJ. Heart rate variability dynamics during controlled hypotension with nicardipine, remifentanil and dexmedetomidine. Acta Anaesthesiol Scand. 2014;58:168-76.

https://doi.org/10.1111/aas.12233

PMid:24261345 

23. Goswami D, Yadav P, Bhatt R, Lakshmanan S, Roychoudhury A, Bhutia O. Comparison of Efficacy of Dexmedetomidine and Clonidine Infusion to Produce Hypotensive Anesthesia in Patients Undergoing Orthognathic Surgery: A Randomized Controlled Trial. J Oral Maxillofac Surg. 2022;80:55-62.

https://doi.org/10.1016/j.joms.2021.06.035

PMid:34339618 

24. Labafchi A, Shooshtari Z, Grillo R, Sharifian Attar A, Eshghpour M, Samieirad S. The Beneficial Effect of Preoperative Dexmedetomidine in Controlling Postoperative Pain, Nausea, and Vomiting After Orthognathic Surgery: A Triple-blind Randomized Clinical Trial. J Oral Maxillofac Surg. 2023;81:941-9.

https://doi.org/10.1016/j.joms.2023.04.014

PMid:37209710 

25. Fu G, Xu L, Chen H, Lin J. State-of-the-art anesthesia practices: a comprehensive review on optimizing patient safety and recovery. BMC Surg. 2025;25:32.

https://doi.org/10.1186/s12893-025-02763-6

PMid:39833810 PMCid:PMC11749226

26. Almasri AMH, Hajeer MY, Sultan K, Aljabban O, Zakaria AS, Alhaffar JB. Evaluation of Satisfaction Levels Following Orthognathic Treatment in Adult Patients: A Systematic Review. Cureus. 2024;16:e73846.

https://doi.org/10.7759/cureus.73846

PMid:39552740

27. Ali SA, Marrapodi MM, Shivakumar GC, Shivakumar S, Hurkadle J, Cicciù M, et al. Efficacy of Orthognathic Surgery in OSAS Patients: A Systematic Review and Meta-Analysis. J Oral Rehabil. 2025;52:554-65.

https://doi.org/10.1111/joor.13936

PMid:39861956 PMCid:PMC11934834

28. Niklasson A, Finan PH, Smith MT, Forsberg A, Dietz N, Kander T, et al. The relationship between preoperative sleep disturbance and acute postoperative pain control: A systematic review and meta-analysis. Sleep Med Rev. 2025;79:102014.

https://doi.org/10.1016/j.smrv.2024.102014

PMid:39504912 

29. Francisco I, Travassos R, Baptista Paula A, Oliveiros B, Marques F, Prata Ribeiro M, et al. Evaluation of quality of life after orthognathic surgery in obstructive sleep apnea syndrome: a systematic review. Angle Orthod. 2025;95:104-25.

https://doi.org/10.2319/020624-99.1

PMid:39509465 PMCid:PMC11662364

30. Ren Y, Wen Z, Zhou S, Lu L, Hua Z, Sun Y. Association of preoperative blood biomarkers with postoperative major adverse cardiac events and mortality in major orthopaedic surgery: a systematic review and meta-analysis. BMJ Open. 2025;15:e086263.

https://doi.org/10.1136/bmjopen-2024-086263

PMid:39819956 PMCid:PMC11752069