Hurtado-Celotti D, Andrés-Veiga M, Madrigal Martínez-Pereda C, Meniz-García C, Santos-Marino J, Martínez-Rodríguez N. Antimicrobial activity of piperacillin/tazobactam against key peri-implant pathogens: an in vitro comparative study with amoxicillin-clavulanate and minocycline. Med Oral Patol Oral Cir Bucal. 2025 Nov 1;30 (6):e934-40.


doi:10.4317/medoral.27797

https://dx.doi.org/doi:10.4317/medoral.27797


1. Lindhe J, Meyle J. Peri-implant diseases: Consensus report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008;35(8 Suppl):282-5.

https://doi.org/10.1111/j.1600-051X.2008.01283.x

PMid:18724855 

2. Renvert S, Polyzois, I. Treatment of pathologic peri-implant pockets. Periodontol 2000. 2018;76:180-90.

https://doi.org/10.1111/prd.12149

PMid:29239086 

3. Parga A, Pose-Rodríguez JM, Muras A, Baus-Domínguez M, Otero-Casal P, Ortega-Quintana ML, Torres-Lagares D, Otero A. Do concurrent peri-implantitis and periodontitis share their microbiotas? A pilot study. Dent J (Basel). 2024;12:113.

https://doi.org/10.3390/dj12040113

PMid:38668025 PMCid:PMC11049029

4. Carvalho ÉBS, Romandini M, Sadilina S, Sant'Ana ACP, Sanz M. Microbiota associated with peri-implantitis. A systematic review with meta-analyses. Clin Oral Implants Res. 2023;34:1176-87.

https://doi.org/10.1111/clr.14153

PMid:37523470 

5. Di Spirito F, Pisano M, Di Palo MP, Franci G, Rupe A, Fiorino A, Rengo C. Peri-implantitis-associated microbiota before and after peri-implantitis treatment, the biofilm "competitive balancing" effect: A systematic review of randomized controlled trials. Microorganisms. 2024;12:1965.

https://doi.org/10.3390/microorganisms12101965

PMid:39458274 PMCid:PMC11509653

6. Porras R, Anderson GB, Caffesse R, Narendran S, Trejo PM. Clinical response to 2 different therapeutic regimens to treat peri-implant mucositis. J Periodontol. 2002;73:1118-25.

https://doi.org/10.1902/jop.2002.73.10.1118

PMid:12416768 

7. Renvert S, Lessem J, Lindahl C, Svensson M. Treatment of incipient peri-implant infections using topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement. J Int Acad Periodontol. 2004;6(4 Suppl):154-9.

PMid:15536784

8. Renvert S, Lessem J, Dahlén G, Lindahl C, Svensson M. Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: A randomized clinical trial. J Clin Periodontol. 2006;33:362-9.

https://doi.org/10.1111/j.1600-051X.2006.00919.x

PMid:16634959 

9. Renvert S, Roos-Jansåker AM, Claffey N. Non-surgical treatment of peri-implant mucositis and peri-implantitis: A literature review. J Clin Periodontol. 2008;35(8 Suppl):305-15.

https://doi.org/10.1111/j.1600-051X.2008.01276.x

PMid:18724858 

10. Renvert S, Lessem J, Dahlén G, Renvert H, Lindahl C. Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: A randomized clinical trial. J Periodontol. 2008;79:836-44.

https://doi.org/10.1902/jop.2008.070347

PMid:18454662 

11. Nart J, de Tapia B, Pujol À, Pascual A, Valles C. Vancomycin and tobramycin impregnated mineralized allograft for the surgical regenerative treatment of peri-implantitis: A 1-year follow-up case series. Clin Oral Investig. 2018;22:2199-207.

https://doi.org/10.1007/s00784-017-2310-0

PMid:29275491 

12. Hurtado-Celotti D, Martínez-Rodríguez N, Ruiz-Sáenz P, Barona-Dorado C, Santos-Marino J, Martínez-González JM. Piperacillin-tazobactam as an adjuvant in the mechanical treatment of patients with periodontitis: A randomized clinical study. Antibiotics (Basel). 2022;11:1689.

https://doi.org/10.3390/antibiotics11121689

PMid:36551346 PMCid:PMC9774547

13. Ilyes I, Rusu D, Rădulescu V, Vela O, Boariu MI, Roman A, Surlin P, Kardaras G, Boia S, Chinnici S, Jentsch HFR, Stratul SI. A placebo-controlled trial to evaluate two locally delivered antibiotic gels (piperacillin plus tazobactam vs. doxycycline) in stage III-IV periodontitis patients. Medicina (Kaunas). 2023;59:303.

https://doi.org/10.3390/medicina59020303

PMid:36837504 PMCid:PMC9961827

14. Ilyes I, Boariu M, Rusu D, Iorio-Siciliano V, Vela O, Boia S, Radulescu V, Șurlin P, Jentsch H, Lodin A, Stratul SI. Comparative study of systemic vs. local antibiotics with subgingival instrumentation in stage III-IV periodontitis: A retrospective analysis. Antibiotics. 2024;13:430.

https://doi.org/10.3390/antibiotics13050430

PMid:38786158 PMCid:PMC11117343

15. Ilyes I, Boariu M, Rusu D, Iorio-Siciliano V, Vela O, Boia S, Kardaras G, Șurlin P, Calniceanu H, Jentsch H, Lodin A, Stratul SI. A single dose of piperacillin plus tazobactam gel as an adjunct to professional mechanical plaque removal (PMPR) in patients with peri-implant mucositis: A 6-month double-blind randomized clinical trial. Antibiotics. 2024;13:269.

https://doi.org/10.3390/antibiotics13030269

PMid:38534704 PMCid:PMC10967304

16. González Regueiro I, Martínez Rodriguez N, Barona Dorado C, Sanz-Sánchez I, Montero E, Ata-Ali J, Duarte F, Martínez-González JM. Surgical approach combining implantoplasty and reconstructive therapy with locally delivered antibiotic in the treatment of peri-implantitis: A prospective clinical case series. Clin Implant Dent Relat Res. 2021;23:864-73.

https://doi.org/10.1111/cid.13049

PMid:34651432 

17. Matarazzo F, Sabóia-Gomes R, Alves BES, de Oliveira RP, Araújo MG. Prevalence, extent and severity of peri-implant diseases. A cross-sectional study based on a university setting in Brazil. J Periodontal Res. 2018;53:910-15.

https://doi.org/10.1111/jre.12582

PMid:29961988 

18. De Almeida JM, Matheus HR, Rodrigues Gusman DJ, Faleiros PL, Januário De Araújo N, Noronha Novaes VC. Effectiveness of mechanical debridement combined with adjunctive therapies for nonsurgical treatment of periimplantitis: A systematic review. Implant Dent. 2017;26:137-44.

https://doi.org/10.1097/ID.0000000000000469

PMid:27548110 

19. Büchter A, Meyer U, Kruse-Lösler B, Joos U, Kleinheinz J. Sustained release of doxycycline for the treatment of peri-implantitis: Randomised controlled trial. Br J Oral Maxillofac Surg. 2004;42:439-44.

https://doi.org/10.1016/j.bjoms.2004.06.005

PMid:15336770 

20. Mensi M, Scotti E, Calza S, Pilloni A, Grusovin MG, Mongardini C. A new multiple anti-infective non-surgical therapy in the treatment of peri-implantitis: A case series. Minerva Stomatol. 2017;66:255-66.

https://doi.org/10.23736/S0026-4970.17.04054-7

PMid:28975771 

21. Schär D, Ramseier CA, Eick S, Arweiler NB, Sculean A, Salvi GE. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: Six-month outcomes of a prospective randomized clinical trial. Clin Oral Implants Res. 2013;24:104-10.

https://doi.org/10.1111/j.1600-0501.2012.02494.x

PMid:22568744 

22. Mombelli A, Feloutzis A, Brägger U, Lang NP. Treatment of peri-implantitis by local delivery of tetracycline: clinical, microbiological and radiological results. Clin Oral Implants Res. 2001;12:287-94.

https://doi.org/10.1034/j.1600-0501.2001.012004287.x

PMid:11488856 

23. Heitz-Mayfield LJA, Salvi GE, Mombelli A, Faddy M, Lang NP. Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study. Clin Oral Implants Res. 2012;23:205-10.

https://doi.org/10.1111/j.1600-0501.2011.02276.x

PMid:22092831 

24. Ardila CM, Bedoya-García JA, Arrubla-Escobar DE. Antibiotic resistance in periodontitis patients: A systematic scoping review of randomized clinical trials. Oral Dis. 2023;29:2501-11.

https://doi.org/10.1111/odi.14288

PMid:35735133 

25. Ardila CM, Vivares-Builes AM. Antibiotic resistance in patients with peri-implantitis: A systematic scoping review. Int J Environ Res Public Health. 2022;19:15609.

https://doi.org/10.3390/ijerph192315609

PMid:36497685 PMCid:PMC9737312

26. Riben Grundström C, Lund B, Kämpe J, Belibasakis GN, Hultin M. Systemic antibiotics in the surgical treatment of peri-implantitis: A randomized placebo-controlled trial. J Clin Periodontol. 2024;51:981-96.

https://doi.org/10.1111/jcpe.13994

PMid:38699828 

27. Feres M, Martins R, Souza JGS, Bertolini M, Barão VAR, Shibli JA. Unraveling the effectiveness of antibiotics for peri-implantitis treatment: A scoping review. Clin Implant Dent Relat Res. 2023;25:767-81.

https://doi.org/10.1111/cid.13239

PMid:37386807