Castanha D, Lessa TCS, Martins-de-Araújo ES, Ismaely-de-Andrade T, Beserra GMB, Onofre-de-Araújo EG, Araújo FA, Andrade ES. Midazolam versus midazolam-promethazine combination for oral sedation in third molar surgery: A randomized split-mouth trial. Med Oral Patol Oral Cir Bucal. 2026 Jul 1;31 (4):e582-7.

doi:10.4317/medoral.28014

https://dx.doi.org/doi:10.4317/medoral.28014


1. Akomolafe AG, Fatusi OA, Folayan MO, Mosaku KS, Adejobi AF, Njokanma AR. Relationship between types of information, dental anxiety, and postoperative pain following third molar surgery: A randomized study. J Oral Maxillofac Surg. 2023;81(3):329-336.
https://doi.org/10.1016/j.joms.2022.10.016
PMid:36493800


 

2. Xu JL, Xia R. Influence factors of dental anxiety in patients with impacted third molar extractions and its correlation with postoperative pain: A prospective study. Med Oral Patol Oral Cir Bucal. 2020;25(6):e714-e719.
https://doi.org/10.4317/medoral.23293
PMid:33037812 PMCid:PMC7648926


 

3. Alyami YD, Farran JK, Alsubhi JA, et al. Dental anxiety among migraine patients. J Med Life. 2021;14(4):498-503.
https://doi.org/10.25122/jml-2021-0004
PMid:34621373 PMCid:PMC8485379


 

4. Kocaturk S, Gur ZB, Gursoytrak B. Can verbal interview decrease preoperative anxiety and postoperative discomfort in oral and maxillofacial surgery patients? A randomized clinical trial. J Oral Maxillofac Surg. 2024;82(11):1425-1432.
https://doi.org/10.1016/j.joms.2024.06.178
PMid:39009060


 

5. Chang H, Yuan Y, Yang G, Liao X, Chen C, Ding G. Comparison of sedative effects of intramuscular and intranasal midazolam for pediatric laceration repair in dental emergency department: A randomized controlled study. J Stomatol Oral Maxillofac Surg. 2023;124(3):101396.
https://doi.org/10.1016/j.jormas.2023.101396
PMid:36707049


 

6. Torun AC, Yüceer E. Should melatonin be used as an alternative sedative and anxiolytic agent in mandibular third molar surgery? J Oral Maxillofac Surg. 2019;77(9):1790-1795.
https://doi.org/10.1016/j.joms.2019.02.045
PMid:30959006


 

7. Faghihian R, Eshghi A, Faghihian H, Kaviani N. Comparison of oral melatonin and midazolam as premedication in children undergoing general anesthesia for dental treatment. Anesth Pain Med. 2018;8(2):e64236.
https://doi.org/10.5812/aapm.64236
PMid:30009151 PMCid:PMC6035375


 

8. Mehran M, Ansari G, Vahid Golpayegani M, Shayeghi S, Shafiei L. Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry. J Dent Res Dent Clin Dent Prospects. 2018;12(3):221-226.
https://doi.org/10.15171/joddd.2018.034
PMid:30443309 PMCid:PMC6231152


 

9. Pandis N, Chung B, Scherer RW, Elbourne D, Altman DG. CONSORT 2010 statement: Extension checklist for reporting within-person randomised trials. BMJ. 2017;357:j2835.
https://doi.org/10.1136/bmj.j2835
PMid:28667088 PMCid:PMC5492474


 

10. de Carvalho RWF, Vasconcelos BC. Pernambuco index: Predictability of the complexity of surgery for impacted lower third molars. Int J Oral Maxillofac Surg. 2018;47(2):234-240.
https://doi.org/10.1016/j.ijom.2017.07.013
PMid:28818641


 

11. Aickin M, Gensler H. Adjusting for multiple testing when reporting research results: The Bonferroni vs Holm methods. Am J Public Health. 1996;86(5):726-8.
https://doi.org/10.2105/AJPH.86.5.726
PMid:8629727 PMCid:PMC1380484


 

12. Bazzano M, Mauceri R, Marcon G, Campisi G. Reducing the anxiety of patients undergoing an oral biopsy by means of graphic novels: An open-label randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2023;28(6):e545-e552.
https://doi.org/10.4317/medoral.25730
PMid:3736841


 

13. Cantisani C, Ricci S, Grieco T, et al. Topical promethazine side effects: Our experience and review of the literature. Biomed Res Int. 2013;2013:151509.
https://doi.org/10.1155/2013/151509
PMid:24350243 PMCid:PMC3852816


 

14. Flores-Pérez C, Flores-Pérez J, Moreno-Rocha LA, et al. Influence of age and gender on the pharmacokinetics of midazolam and the depth of sedation in pediatric patients undergoing minor surgeries. Pharmaceutics. 2023;15(2):440.
https://doi.org/10.3390/pharmaceutics15020440
PMid:36839762 PMCid:PMC9963644


 

15. Barzegari H, Zohrevandi B, Masoumi K, Forouzan A, Darian AA, Khosravi S. Comparison of oral midazolam and promethazine with oral midazolam alone for sedating children during computed tomography. Emerg (Tehran). 2015;3(3):109-113.
https://doi.org/10.22037/emergency.v3i3.6801
PMid:26401177


 

16. TREC Collaborative Group. Rapid tranquillisation for agitated patients in emergency psychiatric rooms: A randomised trial of midazolam versus haloperidol plus promethazine. BMJ. 2003;327(7417):708-713.
https://doi.org/10.1136/bmj.327.7417.708
PMid:14512476 PMCid:PMC200800


 

17. Nadri S, Mahmoudvand H, Taee N, Anbari K, Beiranvand S. Promethazine and oral midazolam preanesthetic children medication. Pediatr Emerg Care. 2020;36(7):e369-e372.
https://doi.org/10.1097/PEC.0000000000001389
PMid:29337835


 

18. Orcuera-Flores JR, Silvestre-Rangil J, Cutando-Soriano A, López-Jiménez J. Current methods of sedation in dental patients: A systematic review of the literature. Med Oral Patol Oral Cir Bucal. 2016;21(5):e579-e586.
https://doi.org/10.4317/medoral.20981
PMid:27475684 PMCid:PMC5005095