Nguyen NAT, Nguyen HT, Nguyen NH, Luu TTT, Truong HN. Aberrant expression and subcellular localization of laminin 332 in oral squamous cell carcinoma: Implications for invasive front assessment. Med Oral Patol Oral Cir Bucal. 2026 Jun 1;31 (5):e631-7.

doi:10.4317/medoral.28040

https://dx.doi.org/doi:10.4317/medoral.28040


1. Federico A, Miglio M, Faraj C. Moderately Advanced Local Oral Squamous Cell Carcinoma With Significant Tumor Burden. Cureus. 2024;16:e72285.
https://doi.org/10.7759/cureus.72285
PMid:39583397


 

2. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229-63.
https://doi.org/10.3322/caac.21834
PMid:38572751


 

3. Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, et al. Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Science. 2018;359:1403-7.
https://doi.org/10.1126/science.aal3622
PMid:29567713 PMCid:PMC6002772


 

4. Vig N, Mackenzie IC, Biddle A. Phenotypic plasticity and epithelial-to-mesenchymal transition in the behaviour and therapeutic response of oral squamous cell carcinoma. J Oral Pathol Med. 2015;44:649-55.
https://doi.org/10.1111/jop.12306
PMid:25594908


 

5. Khalilgharibi N, Mao Y. To form and function: On the role of basement membrane mechanics in tissue development, homeostasis and disease. Open Biol. 2021;11:200360.
https://doi.org/10.1098/rsob.200360
PMid:33593159 PMCid:PMC8061686


 

6. Reis SR, de Souza LF, de Souza VF, Silva LD, Dos Santos JN. Expression of basement membrane laminin in oral squamous cell carcinomas. Braz J Otorhinolaryngol. 2007;73:768-74.
https://doi.org/10.1016/S1808-8694(15)31173-3
PMid:18278223 PMCid:PMC9450599


 

7. Aumailley M. The laminin family. Cell Adh Migr. 2013;7:48-55.
https://doi.org/10.4161/cam.22826
PMid:23263632 PMCid:PMC3544786


 

8. Hamill KJ, Kligys K, Hopkinson SB, Jones JC. Laminin deposition in the extracellular matrix: A complex picture emerges. J Cell Sci. 2009;122:4409-17.
https://doi.org/10.1242/jcs.041095
PMid:19955338 PMCid:PMC2787456


 

9. Mendez E, Houck JR, Gui J, Fan W, Lohavanichbutr P, Rue TC, et al. A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival. Clin Cancer Res. 2009;15:1353-61.
https://doi.org/10.1158/1078-0432.CCR-08-1816
PMid:19228736 PMCid:PMC2683360


 

10. Katoh K, Nakanishi Y, Akimoto S, Yoshimura K, Sato Y, Kodera K, et al. Correlation between laminin-5 γ2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue. Oncology. 2002;62:318-26.
https://doi.org/10.1159/000065063
PMid:12138239


 

11. Rani V, McCullough M, Chandu A. Assessment of laminin-5 in oral dysplasia and squamous cell carcinoma. J Oral Maxillofac Surg. 2013;71:1873-9.
https://doi.org/10.1016/j.joms.2013.04.032
PMid:23891017


 

12. Shi Z, Stack MS. Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma. Histol Histopathol. 2010;25:1201-13.


 

13. Tian W, Cao C, Ma S, Cheng G, Wang J. Novel implication of the basement membrane for breast cancer outcome and immune infiltration. Int J Biol Sci. 2023;19:1645-66.
https://doi.org/10.7150/ijbs.81939
PMid:37056938 PMCid:PMC10086744


 

14. Rahman F, Rao NN, Tippu SR, Patil S, Agarwal S, Srivastava S. The expression of laminin-5 in severe dysplasia/carcinoma in situ and early invasive squamous cell carcinoma: An immunohistochemical study. Minerva Stomatol. 2013;62:139-46.


 

15. Tosios KI, Kapranos N, Papanicolaou SI. Loss of basement membrane components laminin and type IV collagen parallels the progression of oral epithelial neoplasia. Histopathology. 1998;33:261-8.
https://doi.org/10.1046/j.1365-2559.1998.00452.x
PMid:9777393


 

16. Franz M, Berndt A, Gruner M, Richter P, Mirsch J, Hyckel P, et al. Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma. Histochem Cell Biol. 2009;131:651-60.
https://doi.org/10.1007/s00418-009-0559-3
PMid:19198871


 

17. Katayama M, Sekiguchi K. Laminin-5 in epithelial tumour invasion. J Mol Histol. 2004;35:277-86.
https://doi.org/10.1023/B:HIJO.0000032359.35698.fe
PMid:15339047


 

18. Shruthy R, Sharada P, Swaminathan U, Nagamalini BR. Immunohistochemical expression of basement membrane laminin in histological grades of oral squamous cell carcinoma: A semiquantitative analysis. J Oral Maxillofac Pathol. 2013;17:185-9.
https://doi.org/10.4103/0973-029X.119755
PMid:24250076 PMCid:PMC3830224


 

19. Furness PN, Lam EW. Patterns of basement membrane deposition in benign, premalignant, and malignant endometrium. J Clin Pathol. 1987;40:1320-3.
https://doi.org/10.1136/jcp.40.11.1320
PMid:3693569 PMCid:PMC1141232


 

20. Akhavan A, Griffith OL, Soroceanu L, Leonoudakis D, Luciani-Torres MG, Daemen A, et al. Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes. Cancer Res. 2012;72:2578-88.
https://doi.org/10.1158/0008-5472.CAN-11-3732
PMid:22589276 PMCid:PMC3354772


 

21. Sakr WA, Zarbo RJ, Jacobs JR, Crissman JD. Distribution of basement membrane in squamous cell carcinoma of the head and neck. Hum Pathol. 1987;18:1043-50.
https://doi.org/10.1016/S0046-8177(87)80221-6
PMid:3308680


 

22. Bilde A, Von Buchwald C, Dabelsteen E, Therkildsen MH, Dabelsteen S. Molecular markers in the surgical margin of oral carcinomas. J Oral Pathol Med. 2009;38:72-8.
https://doi.org/10.1111/j.1600-0714.2008.00715.x
PMid:19192052


 

23. Celià-Terrassa T, Meca-Cortés O, Mateo F, Martínez de Paz A, Rubio N, Arnal-Estapé A, et al. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest. 2012;122:1849-68.
https://doi.org/10.1172/JCI59218
PMid:22505459 PMCid:PMC3366719

 

24. Bosman FT, Stamenkovic I. Functional structure and composition of the extracellular matrix. J Pathol. 2003;200:423-8.
https://doi.org/10.1002/path.1437
PMid:12845610

 

25. Määttä M, Virtanen I, Burgeson R, Autio-Harmainen H. Comparative analysis of the distribution of laminin chains in the basement membranes in some malignant epithelial tumors: The α1 chain of laminin shows a selected expression pattern in human carcinomas. J Histochem Cytochem. 2001;49:711-25.
https://doi.org/10.1177/002215540104900605
PMid:11373318

 

26. Mostafa WZ, Mahfouz SM, Bosseila M, Sobhi RM, Zaki NS. An Immunohistochemical study of laminin in cutaneous and mucosal squamous cell carcinomas. J Egypt Women Dermatol Soc. 2007;4:24-33.

 

27. Gasparoni A, Fonzi L, Schneider-Stock R, Atallah EB, Al-Hajji MN, Ghasem S, et al. Prognostic value of differential expression of Laminin-5 γ2 in oral squamous cell carcinomas: Correlation with survival. Oncol Rep. 2007;18:793-800.
https://doi.org/10.3892/or.18.4.793
PMid:17786338

 

28. Togni L, Caponio VCA, Zerman N, Troiano G, Zhurakivska K, Lo Muzio L, et al. The emerging impact of tumor budding in oral squamous cell carcinoma: Main issues and clinical relevance of a new prognostic marker. Cancers (Basel). 2022;14(15):3571.
https://doi.org/10.3390/cancers14153571
PMid:35892830 PMCid:PMC9332070