Eloranta R, Nikkilä R, Vilén ST, Wilkman T, Salo T, Snäll J. Identification of high-risk patients and metastatic progression in primary c/pN0 oral
squamous cell carcinoma. Med Oral Patol Oral Cir Bucal.
2026 Sep 1;31 (5):e728-37.
doi:10.4317/medoral.28176
https://dx.doi.org/doi:10.4317/medoral.28176
___
References
|
1.
Aires FT, Lin CS, Matos LL, Kulcsar
MAV, Cernea CR. Risk Factors
for Distant Metastasis in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgical Treatment. ORL J Otorhinolaryngol
Relat Spec.
2017;79(6):347-55. |
|
|
|
|
|
2.
Zanoni DK, Montero PH, Migliacci
JC, Shah JP, Wong RJ, Ganly
I, Patel SG. Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Oral Oncol. 2019;90:115-21. |
|
|
|
|
|
3.
Rizvi ZH, Alonso JE, Kuan
EC, St John MA. Treatment
outcomes of patients with primary squamous cell carcinoma of the retromolar trigone. Laryngoscope.
2018;128(12):2740-4. |
|
|
|
|
|
4.
Sharma A, Kim JW, Paeng
JY. Clinical analysis of neck node metastasis
in oral cavity cancer. J Korean Assoc Oral Maxillofac Surg.
2018;44(6):282-8. |
|
|
|
|
|
5.
Woolgar JA, Triantafyllou
A, Lewis JS, Jr., Hunt J, Williams MD, Takes RP, Thompson LDR, Slootweg
PJ, Devaney KO, Ferlito
A. Prognostic biological features in neck dissection specimens. Eur Arch Otorhinolaryngol.
2013;270(5):1581-92. |
|
|
|
|
|
6.
Cronin KA, Ries LA,
Edwards BK. The Surveillance,
Epidemiology, and End Results (SEER) Program of the National Cancer Institute. Cancer. 2014;120(Suppl 23):3755-7. PMid: 25412387 |
|
|
|
|
|
7.
Pimenta Amaral TM, Da Silva Freire AR, Carvalho AL, Pinto CA, Kowalski LP. Predictive factors of occult metastasis and prognosis of clinical
stages I and II squamous cell carcinoma of the tongue and floor of the mouth. Oral Oncol. 2004;40(8):780-6. |
|
|
|
|
|
8.
Woolgar JA, Rogers SN, Lowe
D, Brown JS, Vaughan ED. Cervical lymph node metastasis
in oral cancer: The importance of even microscopic extracapsular
spread. Oral Oncol. 2003;39(2):130-7. |
|
|
|
|
|
9.
Choi KY, Park SC, Kim JH, Lee DJ. The occult nodal metastasis rate of early tongue cancer (T1-T2): A protocol for a systematic review and meta-analysis.
Medicine (Baltimore). 2021;100(3):e24327. |
|
|
|
|
|
10.
Farrokhian N, Holcomb AJ,
Dimon E, Karadaghy O,
Ward C, Whiteford E, Tolan
C, Hanly EK, Buchakjian
MR, Harding B, Dooley L, Shinn J, Wood CB, Rohde SL, Khaja S, Parikh A, Bulbul MG,
Penn J, Goodwin S, Bur
AM. Development and Validation
of Machine Learning Models
for Predicting Occult Nodal Metastasis in Early-Stage Oral Cavity Squamous Cell Carcinoma. JAMA Netw Open. 2022;5(4):e227226. |
|
|
|
|
|
11.
Feng Z, Li JN, Li CZ, Guo CB. Elective
neck dissection versus observation in the management of early tongue carcinoma with clinically node-negative neck: A retrospective study of 229 cases. J Craniomaxillofac
Surg. 2014;42(6):806-10. |
|
|
|
|
|
12.
Sawant SS, Dongre H, Ahire C, Sharma S, Kannan S, Mahadik S, D Chaukar 2, F Lukmani 1, A Patil 4, A D'Cruz 2, M M Vaidya 1, P Dongre 5. A nomogram for predicting the risk of neck
node metastasis in pathologically node-negative
oral cavity carcinoma. Oral Dis.
2017;23(8):1087-98. |
|
|
|
|
|
13.
Abbas W, Gupta S, Goel V,
Aggarwal A. Predictors of
Occult Neck Metastasis and Extra Capsular Spread in Early Oral Cancers. Indian J Otolaryngol Head Neck Surg. 2022;74(Suppl 2):2122-8. |
|
|
|
|
|
14.
Hosni A, Huang SH, Xu W,
Su J, Bayley A, Bratman
SV, Cho J, Giuliani M,
Kim J, Ringash J, Waldron
J, Spreafico A, De Almeidad
J, O'Sullivan B, Goldstein
D, Hope A. Distant Metastases
Following Postoperative Intensity-Modulated Radiotherapy
for Oral Cavity Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg. 2017;143(4):368-75. |
|
|
|
|
|
15.
Jin WL, Ye WM, Zheng JW, Zhou L, Zhu HG, Zhang ZY, Tian J. Occult cervical lymph node metastases
in 100 consecutive patients
with cN0 tongue cancer. Chin Med J (Engl). 2008;121(19):1871-4. |
|
|
|
|
|
16.
Li Y, Liu K, Ke Y, Zeng Y, Chen M, Li W, Liu W, Hua X, Li Z, Zhong Y, Xie C, Yu H. Risk Factors
Analysis of Pathologically
Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results
from a Cancer Center of
Central China. J Cancer. 2019;10(13):3062-9. |
|
|
|
|
|
17.
Carey RM, Anagnos VJ, Prasad
A, Sangal NR, Rajasekaran
K, Shanti RM, Cannady SB,
Newman JG, Brant JA, Brody
RM. Nodal Metastasis in Surgically
Treated Oral Cavity Squamous Cell Carcinoma. ORL J Otorhinolaryngol Relat Spec. 2023;85(6):348-59. |
|
|
|
|
|
18.
Sagheb K, Blatt S, Rahimi-Nedjat RK, Eigenbrodt S,
Al-Nawas B, Walter C. Cervical metastases
behavior of T1-2 squamous
cell cancer of the oral mucosa. Clin Oral Investig. 2017;21(3):931-5. |
|
|
|
|
|
19.
Melchers LJ, Schuuring E,
van Dijk BA, de Bock GH, Witjes
MJ, van der Laan BF, van der Wal
JE, Roodenburg JLN. Tumour
infiltration depth ≥4 mm is an indication
for an elective neck dissection in pT1cN0 oral squamous
cell carcinoma. Oral Oncol.
2012;48(4):337-42. |
|
|
|
|
|
20.
Ho YY, Wu TY, Cheng HC,
Yang CC, Wu CH. The significance of tumor budding
in oral cancer survival
and its relevance to the eighth edition
of the American Joint Committee on Cancer staging system. Head Neck.
2019;41(9):2991-3001. |
|
|
|
|
|
21.
Khwaja T, Tayaar AS, Acharya S, Bhushan J, Muddapur MV. Pattern of invasion as a factor in determining
lymph node metastasis in oral squamous cell carcinoma. J Cancer Res Ther. 2018;14(2):382-7. |
|
|
|
|
|
22.
Boxberg M, Leising L, Steiger K, Jesinghaus M, Alkhamas A, Mielke M, Pfarr N, Götz C, Wolff KD, Weichert W, Kolk A. Composition and Clinical Impact of the Immunologic Tumor Microenvironment
in Oral Squamous Cell
Carcinoma. J Immunol. 2019;202(1):278-91. |
|
|
|
|
|
23.
Li W, Liu N, Chen M, Liu D, Liu S. Metformin as an immunomodulatory agent in enhancing head and neck squamous cell carcinoma therapies. Biochim Biophys Acta Rev Cancer. 2025;1880(2):189262. |
|
|
|
|
|
24.
Jerjes W, Upile T, Radhi H, Petrie A, Abiola J, Adams A, Kafas P,
Callear J, Carbiner R, Rajaram
K, Hopper C. The effect
of tobacco and alcohol and their
reduction/cessation on mortality in oral cancer patients: Short communication. Head Neck Oncol. 2012;4:6. |
|
|
|
|
|
25.
Edge SB, Compton CC. The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471-4. |
|
|
|
|
|
26.
Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK,
Meyer L, Gress DM, Byrd
DR, Winchester DP. The Eighth
Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized"
approach to cancer staging. CA Cancer J Clin. 2017;67(2):93-9. |
|
|
|
|
|
27.
Lee DH, Bae YJ. AJCC 8th Edition
Staging of Oral Cavity Cancer: Radiologic Evaluation. J Korean Soc Radiol. 2026;87(1):3-11. |
|
|
|
|
|
28.
Morand GB, Vital DG, Kudura
K, Werner J, Stoeckli SJ, Huber GF, Huellner MW. Maximum Standardized Uptake Value (SUV(max)) of Primary Tumor Predicts Occult Neck Metastasis
in Oral Cancer. Sci Rep.
2018;8(1):11817. |
|
|
|
|
|
29.
Eloranta R, Vilén ST, Keinänen A, Salo T, Qannam A,
Bello IO, Snäll J. Oral squamous
cell carcinoma: Effect of
tobacco and alcohol on cancer location. Tob Induc Dis.
2024;22. |
|
|
|
|
|
30.
Mao X, Huang H, Zhao L,
Li F, Wang Z, Yuan X, Lau HC, Hsueh
CY, Zhang M. Complex of intratumoral
mycobiome and bacteriome predicts the recurrence of laryngeal squamous cell carcinoma. Appl Environ Microbiol. 2025;91(3):e0195424. |
|
|
|
|
|
31.
Al Feghali KA, Ghanem AI,
Burmeister C, Chang SS, Ghanem
T, Keller C, Siddiqui F. Impact of smoking on pathological features in oral cavity squamous cell carcinoma. J Cancer Res Ther. 2019;15(3):582-8. |
|
|
|
|
|
32.
Cunningham MJ, Johnson JT, Myers EN, Jr. Schramm VL, Thearle PB.
Cervical lymph node metastasis after local excision of early squamous cell carcinoma of the oral cavity. Am J Surg. 1986;152(4):361-6. |
|
|
|
|
|
33.
El-Naaj IA, Leiser Y, Shveis M, Sabo E, Peled M. Incidence of oral cancer occult metastasis and survival of T1-T2N0
oral cancer patients. J
Oral Maxillofac Surg.
2011;69(10):2674-9. |
|
|
|
|
|
34.
Wang Y, Ow TJ, Myers JN. Pathways
for cervical metastasis
in malignant neoplasms of
the head and neck region. Clin Anat.
2012;25(1):54-71. |
|
|
|
|
|
35.
Fang Q, Gao H, Gao Q, Sun J, Li P, Cui M,
Zhang E, Yin W, Dong Y. Elective neck dissection versus wait-and-see policy in cT1N0 buccal squamous cell carcinoma. BMC Cancer. 2020;20(1):537. |
|
|
|
|
|
36.
Weiss MH, Harrison LB, Isaacs
RS. Use of decision analysis
in planning a management strategy for the stage N0 neck. Arch Otolaryngol
Head Neck Surg.
1994;120(7):699-702. |
|
|
|
|
|
37.
Bittar RF, Ferraro HP,
Ribas MH, Lehn CN. Predictive
factors of occult neck metastasis in patients with oral squamous cell carcinoma. Braz J Otorhinolaryngol.
2016;82(5):543-7. |
|
|
|
|
|
38.
Noorlag R, Boeve K, Witjes MJ, Koole R, Peeters TL, Schuuring E, Willems SM, van Es RJJ. Amplification
and protein overexpression
of cyclin D1: Predictor of occult
nodal metastasis in early
oral cancer. Head Neck.
2017;39(2):326-33. |
|
|
|
|
|
39.
Lin CY, Wang HM, Kang CJ,
Lee LY, Huang SF, Fan KH, Chen
EYC, Chen IH, Liao CT,
Chang JTC. Primary tumor site
as a predictor of treatment outcome
for definitive radiotherapy of advanced-stage
oral cavity cancers. Int J Radiat Oncol Biol Phys.
2010;78(4):1011-9. |
|
|
|
|
|
40.
Larsen SR, Johansen J, Sørensen JA, Krogdahl A. The prognostic significance of histological features in oral squamous cell carcinoma. J Oral Pathol Med. 2009;38(8):657-62. |
|
|
|
|
|
41.
Duprez F, Berwouts D, De Neve W, Bonte K, Boterberg T, Deron P, Huvenne W, Rottey S, Mareel M. Distant metastases in head and neck cancer. Head Neck.
2017;39(9):1733-43. |
|
|
|
|
|
42.
Skinner HD, Sandulache
VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, Fitzgerald AL, Giri U, Ang KK, Myers JN. TP53 disruptive
mutations lead to head and neck
cancer treatment failure through inhibition of radiation-induced
senescence. Clin Cancer Res. 2012;18(1):290-300. |
|
|
|
|
|
43.
Dongoran RA, Wang KH, Lin
TJ, Yuan TC, Liu CH. Anti-Proliferative
Effect of Statins Is Mediated by
DNMT1 Inhibition and p21 Expression
in OSCC Cells. Cancers (Basel). 2020;12(8). |
|
|
|
|
|
44.
Wang ST, Ho HJ, Lin JT, Shieh
JJ, Wu CY. Simvastatin-induced
cell cycle arrest through inhibition of STAT3/SKP2 axis and activation
of AMPK to promote p27 and p21 accumulation
in hepatocellular carcinoma cells.
Cell Death Dis. 2017;8(2):e2626. |
|
|
|
|
|
45.
Chen MC, Tsai YC, Tseng JH, Liou JJ, Horng S, Wen HC, Fan YC, Zhong WB, Hsu SP. Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer. Int J Mol Sci. 2017;18(12). |
|
|
|
|
|
46.
Jiang P, Mukthavaram R,
Chao Y, Nomura N, Bharati
IS, Fogal V, Pastorino S, Teng
D, Cong X, Pingle SC, Kapoor S, Shetty K, Aggrawal A, Vali S, Abbasi T, Chien S, Kesari S. In vitro and in vivo anticancer
effects of mevalonate pathway modulation on human cancer cells. Br J Cancer.
2014;111(8):1562-71. |
|
|
|
|
|
47.
Zätterström U, Boysen M, Evensen JF. Significance of self-reported symptoms as part of follow-up routines in patients treated for oral squamous cell carcinoma. Anticancer Res. 2014;34(11):6593-9. PMid:
25368263 |
|
|
|
|
|
48.
Furukawa MK, Furukawa M.
Diagnosis of lymph node metastases of head and neck cancer and evaluation of effects of chemoradiotherapy using ultrasonography. Int J Clin Oncol.
2010;15(1):23-32. |
|
|
|
|
|
49.
Nakamura T, Sumi M. Nodal imaging
in the neck: Recent advances in US, CT and
MR imaging of metastatic nodes. Eur Radiol.
2007;17(5):1235-41. |
|
|
|
|
|
50.
Sumino J, Uzawa N, Ohyama Y, Michi Y, Kawamata A, Mizutani M, Yamashiro M. First signs of late-presenting
cervical lymph node metastasis in oral cancers during follow-up. Int J Oral Maxillofac Surg. 2017;46(6):676-81. |
|