Sánchez-Ortega H, Varela-Centelles P, Seoane J, López-Cedrún JL, Bilbao-Alonso A, García-Caballero L, Blanco-Hortas A, Seoane-Romero JM. Patient delay in oral cancer in North-Western Spain: Where do we stand?. Med Oral Patol Oral Cir Bucal. 2026. Jun 1;31 (5):e631-7.
doi:10.4317/medoral.28246
https://dx.doi.org/doi:10.4317/medoral.28246
1. World Health Organization. Data visualization tools for exploring the global cancer burden in 2022. Geneva: WHO; 2026. [Accessed 2026-02-08]. Available from: https://gco.iarc.who.int. |
|
|
|
2.
Lu
DN, Zhang WC, Lin YZ, Zhang YN, Shao CY, Zheng CM, Ge MH, Xu JJ.
The incidence trends of oral cancers worldwide from 1988 to 2012
and the prediction up to 2030. Head Neck. 2023
Sep;45(9):2394-2412. |
|
|
|
3.
Wu
J, Chen H, Liu Y, Yang R, An N. The global, regional, and national
burden of oral cancer, 1990-2021: A systematic analysis for the
Global Burden of Disease Study 2021. J Cancer Res Clin Oncol. 2025
Jan
28;151(2):53. |
|
|
|
4.
Gangane
NM, Ghongade PV, Patil BU, Atram M. Oral cavity cancer incidence
and survival trends: A population-based study. J Cancer Res Ther.
2024 Jul
1;20(5):1446-1452. |
|
|
|
5.
Silverman
S, Kerr AR, Epstein JB. Oral and pharyngeal cancer control and
early detection. J Canc Educ. 2010
Sep;25(3):279-281. |
|
|
|
6.
Zanoni
DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG.
Survival outcomes after treatment of cancer of the oral cavity
(1985-2015). Oral Oncol. 2019
Mar;90:115-121. |
|
|
|
7.
Neal
RD, Tharmanathan P, France B, Din NU, Cotton S, Fallon-Ferguson J,
et al. Is increased time to diagnosis and treatment in symptomatic
cancer associated with poorer outcomes? Systematic review. Br J
Cancer. 2015 Mar 31;112
Suppl1:S92-107. |
|
|
|
8.
Gómez
I, Seoane J, Varela-Centelles P, Diz P, Takkouche B. Is diagnostic
delay related to advanced-stage oral cancer? A meta-analysis. Eur
J Oral Sci. 2009
Oct;117(5):541-546. |
|
|
|
9.
Seoane
J, Takkouche B, Varela-Centelles P, Tomás I, Seoane-Romero JM.
Impact of delay in diagnosis on survival to head and neck
carcinomas: A systematic review with meta-analysis. Clin
Otolaryngol. 2012
Apr;37(2):99-106. |
|
|
|
10. Pack GT, Gallo JS. The culpability for delay in treatment of cancer. Am J Cancer. 1938;33:443-462. |
|
|
|
11.
Weller
D, Vedsted P, Rubin G, Walter FM, Emery J, Scott S, Campbell C,
Andersen RS, Hamilton W, Olesen F, Rose P, Nafees S, van Rijswijk
E, Hiom S, Muth C, Beyer M, Neal RD. The Aarhus statement:
Improving design and reporting of studies on early cancer
diagnosis. Br J Cancer. 2012 Mar
27;106(7):1262-1267. |
|
|
|
12.
Varela-Centelles
P, López-Cedrún JL, Fernández-Sanromán J, Seoane-Romero JM,
Santos de Melo N, Álvarez-Nóvoa P, Gómez I, Seoane J. Key
points and time intervals for early diagnosis in symptomatic oral
cancer: A systematic review. Int J Oral Maxillo-fac Surg. 2017
Jan;46(1):1-10. |
|
|
|
13.
Walter
F, Webster A, Scott S, Emery J. The Andersen Model of Total
Patient Delay: A systematic review of its application in cancer
diagnosis. J Health Serv Res Policy. 2012
Apr;17(2):110-118. |
|
|
|
14.
Varela-Centelles
P, Seoane J, Lopez-Cedrun JL, Fernandez-Sanroman J, García-Martin
JM, Takkouche B, Alvarez-Novoa P, Seoane-Romero JM. The length of
patient and primary care time interval in symptomatic oral cancer.
A quantitative systematic review. Clin Otolaryngol. 2018
Feb;43(1):164-171. |
|
|
|
15.
Kumar
S, Heller RF, Pandey U, Tewari V, Bala N, Oanh KT. Delay in
presentation of oral cancer: A multifactor analytical study. Natl
Med J India. 2001 Jan-Feb;14(1):13-7. |
|
|
|
16.
Sargeran
K, Murtomaa H, Safavi SM, Teronen O. Delayed diagnosis of oral
cancer in Iran: Challenge for prevention. Oral Health Prev Dent.
2009;7(1):69-76. |
|
|
|
17.
Varela-Centelles
P, López-Cedrún JL, Fernández-Santromán J, Álvarez-Nóvoa P,
Luaces-Rey R, Pombo-Castro MJ, López-Jornet MP, Seoane J.
Assessment of time intervals in the pathway to oral cancer
diagnosis in north-westerm Spain. Relative contribution of patient
interval.Med Oral Patol Oral Cir Bucal. 2017 Jul
1;22(4):e478-e483. |
|
|
|
18.
Fernández-Martínez
NF, Petrova D, Špacírová Z, Barrios-Rodríguez R, Pérez-Sayáns
M, Martín-delosReyes LM, Pérez-Gómez B, Rodríguez-Barranco M,
Sánchez MJ. The duration of intervals on the oral cancer care
pathway and implications for survival: A systematic review and
meta-analysis. Front Public Health. 2023 Aug
8;11:1183244. |
|
|
|
19.
Scott
SE, Grunfeld EA, McGurk M. Patient's delay in oral cancer: A
systematic review. Community Dent Oral Epidemiol. 2006
Oct;34(5):337-343. |
|
|
|
20.
Arboleda
LPA, de Abreu M, Pinto A, Moyses RA, Warnakulasuriya S, Conway DI,
Virani S, Santos-Silva AR, Curado MP. Head and Neck Cancer
Patients' Health Literacy: A Systematic Review and Meta-Analysis.
Head Neck. 2026
Jun;48(6):1461-1472. |
|
|
|
21.
Abdo
EN, Garrocho A de A, Barbosa AA, Oliveira EL, Franca-Filho L,
Negri SL, Pordeus IA. Time elapsed between the first symptoms,
diagnosis and treatment of oral cancer patients in Belo Horizonte,
Brazil. Med Oral Patol Oral Cir Bucal. 2007 Nov
1;12(7):E469-473. |
|
|
|
22.
Varela-Centelles
PI, López DP, López-Cedrún JL, García-Rozado Á, Baz PC,
Romero-Méndez A, Seoane J. Impact of the Presenting Symptom on
Time Intervals and Diagnostic Routes of Patients with Symptomatic
Oral Cancer. Cancers (Basel). 2021 Oct
14;13(20):5163. |
|
|
|
23.
Hollows
P, McAndrew PG, Perini MG. Delays in the referral and treatment of
oral squamous cell carcinoma. Br Dent J. 2000 Mar
11;188(5):262-265. |
|
|
|
24.
Peacock
ZS, Pogrel MA, Schmidt BL. Exploring the reasons for delay in
treatment of oral cancer. J Am Dent Assoc. 2008
Oct;139(10):1346-1352. |
|
|
|
25.
Keinänen
A, Uittamo J, Snäll J. Do we recognize oral cancer? Primary
professional delay in diagnosis of oral squamous cell carcinoma.
Clin Oral Investig. 2024 Feb
3;28(2):131. |
|
|
|
26.
Lyratzopoulos
G, Abel GA, McPhail S, Neal RD, Rubin GP. Measures of promptness
of cancer diagnosis in primary care: Secondary analysis of
national audit data on patients with 18 common rarer cancers. Br J
Cancer. 2013 Feb
19;108(3):686-690. |
|
|
|
27.
Grafton-Clarke
C, Chen KW, Wilcock J. Diagnosis and referral delays in primary
care for oral squamous cell cancer: A systematic review. Br J Gen
Pract. 2019
Feb;69(679):e112-e126. |
|
|
|
28.
Seoane
J, Otero-Rico A, López-Cedrún JL, Varela-Centelles P. Shorter
specialist time intervals are associated with advanced stage on
symptomatic oral cancer. Oral Dis. 2018
Mar;24(1-2):112-114. |
|
|
|
29.
Lauritzen
BB, Jensen JS, Grønhøj C, Wessel I, von Buchwald C. Impact of
delay in diagnosis and treatment-initiation on disease stage and
survival in oral cavity cancer: A systematic review. Acta Oncol.
2021
Sep;60(9):1083-1090. |
|
|
|
30.
Tirelli G, Boscolo-Rizzo P, Pelloso L, Gardenal N, Giudici F,
Marcuzzo AV, Tofanelli M. Impact of time-to-surgery on survival
and quality of life in oral cancer. Am J Otolaryngol. 2023
Nov-Dec;44(6):103984. |
|
|
|